ENSG00000109805

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000251496 ENSG00000109805 HEK293_OSMI2_2hA HEK293_TMG_2hB NCAPG protein_coding protein_coding 37.21015 8.299673 67.32666 0.8143096 4.060558 3.018529 22.156332 6.125934 38.27829 0.1447985 1.139162 2.641548 0.65302083 0.7508000 0.5719000 -0.17890000 2.209832e-01 1.193576e-22 FALSE TRUE
ENST00000509719 ENSG00000109805 HEK293_OSMI2_2hA HEK293_TMG_2hB NCAPG protein_coding retained_intron 37.21015 8.299673 67.32666 0.8143096 4.060558 3.018529 6.300414 0.000000 14.27319 0.0000000 2.104532 10.480103 0.09962917 0.0000000 0.2096333 0.20963333 1.193576e-22 1.193576e-22 FALSE TRUE
ENST00000510063 ENSG00000109805 HEK293_OSMI2_2hA HEK293_TMG_2hB NCAPG protein_coding protein_coding 37.21015 8.299673 67.32666 0.8143096 4.060558 3.018529 6.272199 1.509664 10.24878 0.7554280 0.936582 2.755035 0.18143750 0.1674667 0.1517000 -0.01576667 9.274133e-01 1.193576e-22 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000109805 E001 4.539604 0.0035185998 1.361665e-01 2.427159e-01 4 17810962 17810976 15 + 0.683 0.407 -1.301
ENSG00000109805 E002 6.101280 0.0026562925 1.230392e-01 2.242928e-01 4 17810977 17810978 2 + 0.782 0.522 -1.118
ENSG00000109805 E003 59.004698 0.0319930541 1.053878e-02 3.006385e-02 4 17810979 17811021 43 + 1.694 1.435 -0.886
ENSG00000109805 E004 64.779942 0.0215738570 6.969987e-03 2.114570e-02 4 17811022 17811027 6 + 1.732 1.491 -0.822
ENSG00000109805 E005 144.469379 0.0129224819 3.639590e-04 1.634567e-03 4 17811028 17811188 161 + 2.075 1.847 -0.767
ENSG00000109805 E006 234.466634 0.0001777229 3.397586e-14 1.033498e-12 4 17812221 17812424 204 + 2.286 2.043 -0.813
ENSG00000109805 E007 308.945175 0.0002067568 4.084901e-16 1.623395e-14 4 17812917 17813145 229 + 2.403 2.178 -0.751
ENSG00000109805 E008 1.492790 0.0351672691 6.155840e-01 7.338272e-01 4 17813146 17813346 201 + 0.348 0.249 -0.668
ENSG00000109805 E009 253.325380 0.0005874478 1.585631e-12 3.758201e-11 4 17814853 17814998 146 + 2.317 2.092 -0.753
ENSG00000109805 E010 157.692822 0.0002395594 5.234834e-07 4.611810e-06 4 17815274 17815358 85 + 2.109 1.924 -0.621
ENSG00000109805 E011 27.812455 0.0108358492 1.315266e-03 5.027608e-03 4 17817196 17817231 36 + 1.394 1.043 -1.244
ENSG00000109805 E012 11.820134 0.0909814762 8.526689e-01 9.086883e-01 4 17817232 17817260 29 + 1.001 1.030 0.107
ENSG00000109805 E013 263.713072 0.0005380045 9.140388e-09 1.135305e-07 4 17817261 17817453 193 + 2.330 2.162 -0.560
ENSG00000109805 E014 252.021075 0.0011560727 3.046779e-06 2.276217e-05 4 17817939 17818088 150 + 2.308 2.164 -0.479
ENSG00000109805 E015 263.530807 0.0006942395 3.350132e-04 1.520451e-03 4 17822983 17823123 141 + 2.319 2.225 -0.313
ENSG00000109805 E016 1.026704 0.0148801276 2.646359e-01 4.025984e-01 4 17823124 17823147 24 + 0.291 0.001 -8.461
ENSG00000109805 E017 121.520431 0.0011653923 7.478320e-01 8.352466e-01 4 17823647 17823671 25 + 1.969 1.977 0.028
ENSG00000109805 E018 133.788037 0.0010731605 9.866076e-03 2.843514e-02 4 17823672 17823698 27 + 2.026 1.932 -0.314
ENSG00000109805 E019 186.773602 0.0005928373 2.228279e-03 7.930620e-03 4 17823699 17823770 72 + 2.170 2.078 -0.306
ENSG00000109805 E020 220.784469 0.0001910784 1.148732e-03 4.466920e-03 4 17824968 17825057 90 + 2.240 2.155 -0.284
ENSG00000109805 E021 295.697329 0.0006421812 5.533815e-02 1.185738e-01 4 17825382 17825561 180 + 2.358 2.324 -0.116
ENSG00000109805 E022 2.702345 0.0053786176 1.868592e-01 3.097892e-01 4 17825562 17825567 6 + 0.521 0.249 -1.581
ENSG00000109805 E023 218.151708 0.0067600840 7.240806e-01 8.177098e-01 4 17828278 17828388 111 + 2.214 2.254 0.134
ENSG00000109805 E024 252.253575 0.0001922547 2.435914e-01 3.783960e-01 4 17830997 17831116 120 + 2.273 2.330 0.190
ENSG00000109805 E025 344.675914 0.0001713618 4.721516e-04 2.053673e-03 4 17834299 17834523 225 + 2.398 2.506 0.359
ENSG00000109805 E026 353.555412 0.0017887354 5.874705e-03 1.828277e-02 4 17837159 17837340 182 + 2.411 2.517 0.356
ENSG00000109805 E027 433.563585 0.0002969509 1.165808e-05 7.629501e-05 4 17837627 17837801 175 + 2.497 2.617 0.399
ENSG00000109805 E028 355.160021 0.0005433305 7.876682e-07 6.690042e-06 4 17839676 17839837 162 + 2.404 2.551 0.489
ENSG00000109805 E029 279.189835 0.0037801432 5.373124e-07 4.723976e-06 4 17840071 17840209 139 + 2.282 2.500 0.728
ENSG00000109805 E030 232.673677 0.0072404110 6.477298e-06 4.494889e-05 4 17840607 17840693 87 + 2.196 2.446 0.834
ENSG00000109805 E031 245.647192 0.0052619602 1.593615e-09 2.275784e-08 4 17842310 17842379 70 + 2.209 2.496 0.958
ENSG00000109805 E032 389.312076 0.0022890866 1.078373e-08 1.321696e-07 4 17843302 17844865 1564 + 2.431 2.631 0.666