ENSG00000109762

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000264694 ENSG00000109762 HEK293_OSMI2_2hA HEK293_TMG_2hB SNX25 protein_coding protein_coding 7.23702 2.655297 9.866838 0.1201561 0.2479555 1.889753 4.6916088 2.05263088 4.806153 0.27452476 1.0195624 1.223396 0.65622083 0.76933333 0.4839667 -0.2853667 0.142837891 0.002300614 FALSE TRUE
ENST00000652585 ENSG00000109762 HEK293_OSMI2_2hA HEK293_TMG_2hB SNX25 protein_coding protein_coding 7.23702 2.655297 9.866838 0.1201561 0.2479555 1.889753 1.0779317 0.13035837 2.818478 0.05464686 0.4623662 4.332839 0.14548750 0.04900000 0.2880000 0.2390000 0.002518886 0.002300614 FALSE TRUE
MSTRG.25817.4 ENSG00000109762 HEK293_OSMI2_2hA HEK293_TMG_2hB SNX25 protein_coding   7.23702 2.655297 9.866838 0.1201561 0.2479555 1.889753 0.1751894 0.16718656 0.000000 0.08754924 0.0000000 -4.147197 0.03252917 0.06570000 0.0000000 -0.0657000 0.024269296 0.002300614 FALSE TRUE
MSTRG.25817.5 ENSG00000109762 HEK293_OSMI2_2hA HEK293_TMG_2hB SNX25 protein_coding   7.23702 2.655297 9.866838 0.1201561 0.2479555 1.889753 0.9037134 0.03797812 1.828719 0.03797812 0.4493315 5.260181 0.08639167 0.01313333 0.1858333 0.1727000 0.002300614 0.002300614 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000109762 E001 0.8082883 0.0230203267 3.427358e-04 1.551055e-03 4 185204237 185204467 231 + 0.000 0.591 12.852
ENSG00000109762 E002 16.8613104 0.0132916636 2.575903e-05 1.556858e-04 4 185209598 185210111 514 + 1.302 0.752 -2.035
ENSG00000109762 E003 5.6735757 0.0251406111 4.196430e-03 1.369464e-02 4 185210112 185210129 18 + 0.877 0.336 -2.487
ENSG00000109762 E004 9.3929564 0.0160766790 2.353799e-02 5.885880e-02 4 185210130 185210160 31 + 1.041 0.706 -1.290
ENSG00000109762 E005 19.2277882 0.0222181160 1.491040e-03 5.607406e-03 4 185210161 185210255 95 + 1.340 0.933 -1.464
ENSG00000109762 E006 24.2742548 0.0389507445 1.859260e-01 3.086499e-01 4 185247294 185247378 85 + 1.399 1.221 -0.624
ENSG00000109762 E007 46.0068388 0.0007143231 5.020235e-01 6.381425e-01 4 185258848 185259064 217 + 1.637 1.596 -0.139
ENSG00000109762 E008 33.8168774 0.0125542287 6.124495e-01 7.313745e-01 4 185264438 185264498 61 + 1.485 1.525 0.135
ENSG00000109762 E009 39.5753888 0.0006031036 8.870091e-01 9.317499e-01 4 185264499 185264610 112 + 1.566 1.556 -0.035
ENSG00000109762 E010 63.3044724 0.0004119735 1.020656e-01 1.936546e-01 4 185266969 185267155 187 + 1.783 1.698 -0.285
ENSG00000109762 E011 48.5741859 0.0005294087 1.023661e-02 2.934723e-02 4 185288012 185288082 71 + 1.682 1.527 -0.528
ENSG00000109762 E012 0.0000000       4 185295827 185296030 204 +      
ENSG00000109762 E013 69.7404917 0.0004169589 5.351796e-02 1.154053e-01 4 185310635 185310816 182 + 1.827 1.732 -0.320
ENSG00000109762 E014 39.4147792 0.0045153058 5.898955e-03 1.834504e-02 4 185320733 185320844 112 + 1.609 1.405 -0.700
ENSG00000109762 E015 20.5118022 0.0152938725 2.653701e-01 4.034214e-01 4 185320845 185320864 20 + 1.319 1.205 -0.399
ENSG00000109762 E016 64.9638380 0.0007148326 9.541720e-02 1.835148e-01 4 185323528 185323800 273 + 1.790 1.704 -0.293
ENSG00000109762 E017 49.0990544 0.0005600248 5.570654e-01 6.855641e-01 4 185332595 185332713 119 + 1.657 1.621 -0.120
ENSG00000109762 E018 29.9720980 0.0087568344 9.229816e-01 9.554247e-01 4 185332714 185332759 46 + 1.440 1.428 -0.040
ENSG00000109762 E019 47.3614857 0.0040518335 5.723111e-01 6.984464e-01 4 185339379 185339510 132 + 1.624 1.657 0.111
ENSG00000109762 E020 48.1815141 0.0005185853 9.710145e-01 9.858858e-01 4 185341976 185342116 141 + 1.639 1.639 0.001
ENSG00000109762 E021 41.8494878 0.0013663302 1.893958e-01 3.129771e-01 4 185346537 185346650 114 + 1.561 1.639 0.264
ENSG00000109762 E022 46.8847487 0.0004887757 1.104355e-01 2.061739e-01 4 185351445 185351609 165 + 1.607 1.693 0.294
ENSG00000109762 E023 0.7416694 0.0182543975 8.589424e-01 9.129940e-01 4 185353058 185353484 427 + 0.237 0.199 -0.321
ENSG00000109762 E024 53.1878710 0.0004907898 5.099539e-02 1.109367e-01 4 185353485 185353602 118 + 1.651 1.751 0.339
ENSG00000109762 E025 46.6915113 0.0096457273 6.846249e-02 1.408223e-01 4 185357671 185357737 67 + 1.587 1.712 0.424
ENSG00000109762 E026 61.7913239 0.0018130683 9.076841e-04 3.640864e-03 4 185361924 185362105 182 + 1.693 1.859 0.558
ENSG00000109762 E027 33.4898904 0.0010056987 1.464889e-03 5.522762e-03 4 185362611 185362711 101 + 1.425 1.627 0.691
ENSG00000109762 E028 54.6062829 0.0005151063 6.927283e-08 7.256181e-07 4 185363385 185363971 587 + 1.609 1.872 0.890
ENSG00000109762 E029 2.3164804 0.0130482973 4.133418e-01 5.568492e-01 4 185369750 185370185 436 + 0.450 0.592 0.680