ENSG00000109685

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000503991 ENSG00000109685 HEK293_OSMI2_2hA HEK293_TMG_2hB NSD2 protein_coding scaRNA 47.42338 39.20638 50.07169 1.420313 0.7576683 0.3528268 2.808045 0.000000 2.357102 0.000000 1.2195205 7.886978 0.0503250 0.0000000 0.04636667 0.04636667 2.044214e-01 8.839137e-45   FALSE
ENST00000508803 ENSG00000109685 HEK293_OSMI2_2hA HEK293_TMG_2hB NSD2 protein_coding protein_coding 47.42338 39.20638 50.07169 1.420313 0.7576683 0.3528268 17.757622 16.715955 18.571804 2.558431 0.8278937 0.151802 0.3802833 0.4229000 0.37106667 -0.05183333 7.381192e-01 8.839137e-45 FALSE TRUE
ENST00000509115 ENSG00000109685 HEK293_OSMI2_2hA HEK293_TMG_2hB NSD2 protein_coding protein_coding 47.42338 39.20638 50.07169 1.420313 0.7576683 0.3528268 4.892615 0.000000 10.064795 0.000000 0.7689118 9.976535 0.0955500 0.0000000 0.20156667 0.20156667 8.839137e-45 8.839137e-45 FALSE TRUE
ENST00000677895 ENSG00000109685 HEK293_OSMI2_2hA HEK293_TMG_2hB NSD2 protein_coding protein_coding 47.42338 39.20638 50.07169 1.420313 0.7576683 0.3528268 4.950832 9.414588 1.291632 1.151824 0.1075436 -2.856108 0.1139958 0.2395333 0.02576667 -0.21376667 3.680773e-25 8.839137e-45 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000109685 E001 1.0330470 0.0118927735 2.950231e-03 1.011753e-02 4 1871393 1871410 18 + 0.507 0.000 -22.862
ENSG00000109685 E002 1.5813693 0.0086709563 4.231012e-02 9.529020e-02 4 1871411 1871413 3 + 0.548 0.223 -1.919
ENSG00000109685 E003 1.8801337 0.0075807992 1.308192e-02 3.610096e-02 4 1871414 1871433 20 + 0.620 0.223 -2.242
ENSG00000109685 E004 2.1788981 0.0066282545 3.904425e-03 1.287567e-02 4 1871434 1871442 9 + 0.681 0.223 -2.505
ENSG00000109685 E005 2.3712117 0.0096337574 1.364454e-02 3.741484e-02 4 1871443 1871447 5 + 0.681 0.302 -1.920
ENSG00000109685 E006 2.8151488 0.0065865704 2.461553e-03 8.648465e-03 4 1871448 1871448 1 + 0.760 0.302 -2.242
ENSG00000109685 E007 6.8269486 0.0024824664 6.367943e-04 2.669118e-03 4 1871449 1871453 5 + 1.047 0.670 -1.460
ENSG00000109685 E008 14.7205262 0.0054711630 1.017944e-03 4.020648e-03 4 1871454 1871460 7 + 1.314 1.056 -0.919
ENSG00000109685 E009 55.4911151 0.0004292225 4.366880e-11 8.185341e-10 4 1871461 1871542 82 + 1.872 1.607 -0.896
ENSG00000109685 E010 0.8105550 0.0139488320 1.507834e-01 2.627457e-01 4 1887501 1887690 190 + 0.355 0.125 -1.919
ENSG00000109685 E011 4.6867617 0.0035027562 1.838164e-03 6.721248e-03 4 1892166 1892169 4 + 0.918 0.524 -1.637
ENSG00000109685 E012 10.9319358 0.0382671091 6.142151e-02 1.290250e-01 4 1892170 1892263 94 + 1.175 0.970 -0.742
ENSG00000109685 E013 0.9159869 0.0145628223 7.941783e-02 1.586091e-01 4 1892782 1892844 63 + 0.412 0.125 -2.242
ENSG00000109685 E014 0.9170311 0.0442592528 3.888634e-01 5.329567e-01 4 1892845 1892891 47 + 0.355 0.222 -0.923
ENSG00000109685 E015 10.7978512 0.0016192306 7.123549e-06 4.895828e-05 4 1893730 1893909 180 + 1.242 0.825 -1.533
ENSG00000109685 E016 0.4031496 0.0248221160 2.157189e-01 3.452559e-01 4 1899218 1899220 3 + 0.000 0.223 22.868
ENSG00000109685 E017 1.4631633 0.0116192686 6.753408e-01 7.806518e-01 4 1899221 1899395 175 + 0.412 0.369 -0.242
ENSG00000109685 E018 0.1451727 0.0434431242 4.623816e-01   4 1900619 1900625 7 + 0.119 0.000 -22.253
ENSG00000109685 E019 53.5351450 0.0004002086 5.055984e-09 6.593522e-08 4 1900626 1900636 11 + 1.843 1.611 -0.787
ENSG00000109685 E020 58.4773649 0.0004198248 4.070386e-09 5.389147e-08 4 1900637 1900649 13 + 1.877 1.655 -0.753
ENSG00000109685 E021 493.0324469 0.0029191616 1.321596e-15 4.923746e-14 4 1900650 1901251 602 + 2.781 2.594 -0.623
ENSG00000109685 E022 293.2955288 0.0015480571 1.740749e-17 8.271372e-16 4 1904216 1904378 163 + 2.555 2.370 -0.619
ENSG00000109685 E023 7.6844173 0.0021062868 1.309592e-03 5.009354e-03 4 1912091 1912194 104 + 1.082 0.755 -1.243
ENSG00000109685 E024 326.9946205 0.0014961551 6.680663e-13 1.687059e-11 4 1916871 1917037 167 + 2.582 2.441 -0.469
ENSG00000109685 E025 414.3959025 0.0003381551 2.043400e-06 1.586346e-05 4 1918141 1918431 291 + 2.636 2.597 -0.130
ENSG00000109685 E026 305.7927373 0.0013472838 1.292749e-03 4.951627e-03 4 1918432 1918623 192 + 2.503 2.470 -0.111
ENSG00000109685 E027 6.5951702 0.0084117156 2.359861e-02 5.898313e-02 4 1918624 1919187 564 + 0.994 0.754 -0.923
ENSG00000109685 E028 268.0108188 0.0001899481 8.996961e-05 4.748690e-04 4 1930626 1930729 104 + 2.446 2.410 -0.119
ENSG00000109685 E029 207.6206971 0.0007956103 4.332487e-03 1.407570e-02 4 1930730 1930770 41 + 2.331 2.303 -0.093
ENSG00000109685 E030 316.4587567 0.0001583723 1.333205e-04 6.736502e-04 4 1935144 1935262 119 + 2.512 2.486 -0.089
ENSG00000109685 E031 0.0000000       4 1938404 1938450 47 +      
ENSG00000109685 E032 226.2230490 0.0002826945 3.522515e-02 8.207533e-02 4 1938451 1938532 82 + 2.353 2.353 -0.001
ENSG00000109685 E033 0.5869318 0.4004802347 9.488163e-01 9.719232e-01 4 1939281 1939653 373 + 0.212 0.216 0.031
ENSG00000109685 E034 124.9902930 0.0002933164 7.344441e-01 8.253886e-01 4 1939654 1939660 7 + 2.074 2.113 0.134
ENSG00000109685 E035 208.6923704 0.0001975891 1.593243e-01 2.742138e-01 4 1939661 1939751 91 + 2.309 2.325 0.053
ENSG00000109685 E036 138.0150270 0.0002894451 1.205261e-02 3.365909e-02 4 1939752 1939778 27 + 2.153 2.127 -0.088
ENSG00000109685 E037 102.2726060 0.0157815845 3.025020e-04 1.389692e-03 4 1939779 1941334 1556 + 2.109 1.910 -0.668
ENSG00000109685 E038 45.3844871 0.0230194341 1.910421e-01 3.150558e-01 4 1941335 1942338 1004 + 1.697 1.637 -0.205
ENSG00000109685 E039 26.8279594 0.0007059495 2.448646e-01 3.798816e-01 4 1942339 1942432 94 + 1.460 1.433 -0.095
ENSG00000109685 E040 32.7555118 0.0283034108 8.264438e-01 8.907712e-01 4 1942433 1942565 133 + 1.513 1.549 0.121
ENSG00000109685 E041 268.1904257 0.0021936563 1.666853e-01 2.838805e-01 4 1942566 1948818 6253 + 2.424 2.433 0.032
ENSG00000109685 E042 225.4854903 0.0002772620 5.376733e-04 2.300946e-03 4 1951072 1951203 132 + 2.369 2.335 -0.112
ENSG00000109685 E043 4.9082930 0.0818955106 7.815418e-02 1.565008e-01 4 1951999 1952104 106 + 0.883 0.610 -1.110
ENSG00000109685 E044 2.7733014 0.0759213328 5.975106e-01 7.192501e-01 4 1952105 1952107 3 + 0.586 0.530 -0.254
ENSG00000109685 E045 175.0514318 0.0008784457 9.776116e-03 2.821149e-02 4 1952108 1952231 124 + 2.256 2.229 -0.088
ENSG00000109685 E046 34.4181095 0.0005994728 6.008180e-08 6.369868e-07 4 1952752 1953117 366 + 1.674 1.399 -0.941
ENSG00000109685 E047 15.0875454 0.0013215594 1.980015e-02 5.106219e-02 4 1953118 1953187 70 + 1.280 1.126 -0.544
ENSG00000109685 E048 19.3396166 0.0009663004 1.634941e-02 4.349412e-02 4 1953188 1953323 136 + 1.377 1.240 -0.476
ENSG00000109685 E049 252.1872291 0.0025516017 5.295910e-03 1.673719e-02 4 1953324 1953524 201 + 2.421 2.382 -0.128
ENSG00000109685 E050 0.5514428 0.0196933342 9.321469e-02 1.801470e-01 4 1953814 1953982 169 + 0.000 0.302 23.518
ENSG00000109685 E051 1.3317071 0.0120502042 5.406218e-01 6.717300e-01 4 1954537 1954685 149 + 0.290 0.427 0.816
ENSG00000109685 E052 155.8693079 0.0025755658 4.058487e-02 9.209354e-02 4 1955161 1955226 66 + 2.205 2.180 -0.082
ENSG00000109685 E053 209.3141149 0.0053947648 1.604809e-01 2.757683e-01 4 1955227 1955340 114 + 2.325 2.317 -0.026
ENSG00000109685 E054 1.7766895 0.0393539290 3.475825e-01 4.917988e-01 4 1955579 1955692 114 + 0.508 0.369 -0.727
ENSG00000109685 E055 234.6713229 0.0001875696 2.282258e-02 5.737429e-02 4 1955693 1955849 157 + 2.370 2.368 -0.009
ENSG00000109685 E056 163.8961856 0.0004898176 3.342203e-01 4.779690e-01 4 1955983 1956086 104 + 2.200 2.222 0.076
ENSG00000109685 E057 182.6622678 0.0002848403 7.236427e-01 8.174150e-01 4 1956087 1956188 102 + 2.236 2.278 0.138
ENSG00000109685 E058 198.3585604 0.0011835511 1.096954e-01 2.051113e-01 4 1957933 1958036 104 + 2.294 2.299 0.014
ENSG00000109685 E059 1.5478548 0.0169047126 8.119992e-01 8.807190e-01 4 1959296 1959470 175 + 0.355 0.427 0.404
ENSG00000109685 E060 288.0093829 0.0068223782 4.017193e-01 5.454192e-01 4 1959471 1959617 147 + 2.449 2.468 0.066
ENSG00000109685 E061 277.5805132 0.0015394184 9.576008e-02 1.840353e-01 4 1959618 1959740 123 + 2.441 2.446 0.019
ENSG00000109685 E062 311.6242220 0.0001611332 5.794415e-01 7.043487e-01 4 1961035 1961151 117 + 2.471 2.511 0.133
ENSG00000109685 E063 0.5963950 0.4062168435 5.583702e-01 6.866222e-01 4 1974633 1974635 3 + 0.120 0.291 1.587
ENSG00000109685 E064 43.3011607 0.0005890909 2.517309e-10 4.142964e-09 4 1974636 1974786 151 + 1.371 1.785 1.415
ENSG00000109685 E065 43.4696160 0.0018333614 1.017194e-08 1.252058e-07 4 1974787 1974862 76 + 1.388 1.781 1.341
ENSG00000109685 E066 431.9056168 0.0001389713 2.811803e-03 9.709414e-03 4 1974863 1975004 142 + 2.576 2.680 0.346
ENSG00000109685 E067 378.5858576 0.0001951812 4.916868e-02 1.076788e-01 4 1975294 1975400 107 + 2.527 2.616 0.296
ENSG00000109685 E068 1.2910239 0.0102079252 1.303442e-01 2.346360e-01 4 1975401 1975646 246 + 0.462 0.223 -1.504
ENSG00000109685 E069 2.3333280 0.0468199069 1.757893e-01 2.957091e-01 4 1976353 1976474 122 + 0.355 0.636 1.393
ENSG00000109685 E070 438.3523543 0.0014605213 1.156059e-03 4.491999e-03 4 1976475 1976679 205 + 2.565 2.697 0.442
ENSG00000109685 E071 2834.2864889 0.0026755952 2.821280e-27 3.732423e-25 4 1978638 1982207 3570 + 3.284 3.559 0.915