ENSG00000109670

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000281708 ENSG00000109670 HEK293_OSMI2_2hA HEK293_TMG_2hB FBXW7 protein_coding protein_coding 6.330184 3.131986 9.14165 0.1877213 0.3421425 1.542355 0.5335758 0.29481196 1.0293296 0.15391835 0.05492850 1.7696618 0.09428333 0.08923333 0.11276667 0.02353333 0.7937589710 0.0003772622 FALSE TRUE
ENST00000296555 ENSG00000109670 HEK293_OSMI2_2hA HEK293_TMG_2hB FBXW7 protein_coding protein_coding 6.330184 3.131986 9.14165 0.1877213 0.3421425 1.542355 0.3942950 0.41394006 0.1264150 0.41394006 0.07644820 -1.6358579 0.10436667 0.13416667 0.01356667 -0.12060000 1.0000000000 0.0003772622 FALSE TRUE
ENST00000393956 ENSG00000109670 HEK293_OSMI2_2hA HEK293_TMG_2hB FBXW7 protein_coding protein_coding 6.330184 3.131986 9.14165 0.1877213 0.3421425 1.542355 0.6328770 0.74167654 0.5600935 0.37986516 0.04321662 -0.3989134 0.11233333 0.23443333 0.06130000 -0.17313333 0.7407735427 0.0003772622 FALSE TRUE
ENST00000603548 ENSG00000109670 HEK293_OSMI2_2hA HEK293_TMG_2hB FBXW7 protein_coding protein_coding 6.330184 3.131986 9.14165 0.1877213 0.3421425 1.542355 1.2818980 0.65553900 2.0696483 0.12065645 0.23458434 1.6437444 0.21961250 0.21500000 0.22883333 0.01383333 0.9323754210 0.0003772622 FALSE TRUE
ENST00000603841 ENSG00000109670 HEK293_OSMI2_2hA HEK293_TMG_2hB FBXW7 protein_coding protein_coding 6.330184 3.131986 9.14165 0.1877213 0.3421425 1.542355 2.5214901 0.58978531 4.3219928 0.14613917 0.50321207 2.8525128 0.31829167 0.18456667 0.46996667 0.28540000 0.0003772622 0.0003772622 FALSE TRUE
ENST00000604095 ENSG00000109670 HEK293_OSMI2_2hA HEK293_TMG_2hB FBXW7 protein_coding processed_transcript 6.330184 3.131986 9.14165 0.1877213 0.3421425 1.542355 0.1656005 0.32354937 0.1574003 0.05732960 0.04629229 -0.9945978 0.04032917 0.10606667 0.01763333 -0.08843333 0.0009098449 0.0003772622 TRUE FALSE
ENST00000604316 ENSG00000109670 HEK293_OSMI2_2hA HEK293_TMG_2hB FBXW7 protein_coding retained_intron 6.330184 3.131986 9.14165 0.1877213 0.3421425 1.542355 0.3571235 0.05579139 0.5419419 0.02803269 0.06884815 3.0685457 0.05409167 0.01796667 0.05956667 0.04160000 0.0816112771 0.0003772622 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000109670 E001 193.7059366 0.0026708149 2.609842e-17 1.206213e-15 4 152320544 152322818 2275 - 2.153 2.428 0.918
ENSG00000109670 E002 27.6649416 0.0011273818 1.833880e-01 3.054591e-01 4 152322819 152322874 56 - 1.393 1.503 0.380
ENSG00000109670 E003 63.3820523 0.0004279389 1.131933e-01 2.101831e-01 4 152322875 152323149 275 - 1.747 1.839 0.309
ENSG00000109670 E004 0.9202533 0.0407142100 5.074808e-01 6.429913e-01 4 152323150 152324183 1034 - 0.304 0.183 -0.952
ENSG00000109670 E005 51.1290564 0.0004329464 5.909576e-01 7.137721e-01 4 152324184 152324394 211 - 1.690 1.682 -0.028
ENSG00000109670 E006 17.1871814 0.0107623288 7.879746e-05 4.222941e-04 4 152324395 152326005 1611 - 1.327 0.892 -1.573
ENSG00000109670 E007 62.2501389 0.0011248017 8.759103e-02 1.714826e-01 4 152326006 152326221 216 - 1.792 1.727 -0.221
ENSG00000109670 E008 26.3346147 0.0032368013 8.032183e-02 1.600683e-01 4 152326222 152326231 10 - 1.440 1.320 -0.415
ENSG00000109670 E009 54.9806442 0.0005928755 5.665894e-03 1.772903e-02 4 152328208 152328389 182 - 1.757 1.632 -0.423
ENSG00000109670 E010 1.3608519 0.0102989842 5.113854e-02 1.111983e-01 4 152328390 152329073 684 - 0.206 0.558 2.106
ENSG00000109670 E011 37.3645778 0.0008177439 1.006102e-01 1.913838e-01 4 152329672 152329785 114 - 1.585 1.503 -0.281
ENSG00000109670 E012 43.8680886 0.0019837134 2.402450e-02 5.986596e-02 4 152330732 152330868 137 - 1.660 1.543 -0.399
ENSG00000109670 E013 41.4091750 0.0005000613 1.435047e-02 3.902691e-02 4 152332596 152332719 124 - 1.637 1.510 -0.432
ENSG00000109670 E014 0.0000000       4 152332720 152332767 48 -      
ENSG00000109670 E015 38.3367965 0.0005915097 1.163748e-01 2.147833e-01 4 152337802 152337936 135 - 1.587 1.510 -0.263
ENSG00000109670 E016 0.8073459 0.0159739340 5.983695e-01 7.199747e-01 4 152346812 152346929 118 - 0.206 0.311 0.784
ENSG00000109670 E017 38.2397978 0.0044912106 1.040559e-01 1.966843e-01 4 152346930 152347071 142 - 1.590 1.497 -0.317
ENSG00000109670 E018 0.0000000       4 152348674 152348806 133 -      
ENSG00000109670 E019 27.3360885 0.0018236993 1.833276e-01 3.053826e-01 4 152350042 152350124 83 - 1.449 1.371 -0.271
ENSG00000109670 E020 1.9552734 0.0618919618 7.563328e-01 8.414224e-01 4 152352470 152352826 357 - 0.418 0.492 0.377
ENSG00000109670 E021 0.6633060 0.0220582147 8.872369e-01 9.319526e-01 4 152382189 152382529 341 - 0.206 0.183 -0.214
ENSG00000109670 E022 0.2214452 0.0451462414 1.926533e-01   4 152411160 152411302 143 - 0.000 0.183 11.487
ENSG00000109670 E023 18.4992375 0.0009518217 1.166840e-01 2.152303e-01 4 152411303 152411328 26 - 1.297 1.179 -0.416
ENSG00000109670 E024 44.7590556 0.0005383671 8.737685e-01 9.228723e-01 4 152411329 152411592 264 - 1.626 1.637 0.036
ENSG00000109670 E025 45.7120704 0.0004840880 3.584288e-05 2.090011e-04 4 152411593 152411872 280 - 1.699 1.474 -0.769
ENSG00000109670 E026 0.0000000       4 152411873 152411878 6 -      
ENSG00000109670 E027 6.4956068 0.0038484013 1.262921e-01 2.289906e-01 4 152412480 152412529 50 - 0.908 0.714 -0.762
ENSG00000109670 E028 0.0000000       4 152412530 152412606 77 -      
ENSG00000109670 E029 0.8836079 0.0132110178 8.829956e-02 1.725256e-01 4 152451660 152451776 117 - 0.345 0.000 -11.957
ENSG00000109670 E030 7.4531309 0.0024529443 2.913580e-09 3.963871e-08 4 152530273 152530850 578 - 0.535 1.249 2.783
ENSG00000109670 E031 19.5728634 0.0010035145 7.882966e-01 8.644534e-01 4 152534941 152535033 93 - 1.288 1.285 -0.010
ENSG00000109670 E032 9.2593327 0.0019376399 2.110133e-01 3.397356e-01 4 152535034 152535126 93 - 1.022 0.892 -0.486
ENSG00000109670 E033 39.2072053 0.0112064418 5.537144e-01 6.828123e-01 4 152535127 152536092 966 - 1.583 1.556 -0.092