ENSG00000109586

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000265000 ENSG00000109586 HEK293_OSMI2_2hA HEK293_TMG_2hB GALNT7 protein_coding protein_coding 9.675204 2.953576 16.46 0.2132259 0.3549563 2.47443 5.4178466 1.9566218 9.693231 0.2908782 0.6075495 2.302746 0.57099583 0.66896667 0.58963333 -0.07933333 0.77197568 0.03895578 FALSE TRUE
ENST00000505308 ENSG00000109586 HEK293_OSMI2_2hA HEK293_TMG_2hB GALNT7 protein_coding protein_coding 9.675204 2.953576 16.46 0.2132259 0.3549563 2.47443 0.2474867 0.6124940 0.000000 0.3077429 0.0000000 -5.959988 0.09652917 0.20830000 0.00000000 -0.20830000 0.03895578 0.03895578 FALSE TRUE
MSTRG.25729.1 ENSG00000109586 HEK293_OSMI2_2hA HEK293_TMG_2hB GALNT7 protein_coding   9.675204 2.953576 16.46 0.2132259 0.3549563 2.47443 2.4806908 0.2775867 4.502774 0.1481749 0.2866741 3.971946 0.18472083 0.08833333 0.27386667 0.18553333 0.21052076 0.03895578 FALSE TRUE
MSTRG.25729.2 ENSG00000109586 HEK293_OSMI2_2hA HEK293_TMG_2hB GALNT7 protein_coding   9.675204 2.953576 16.46 0.2132259 0.3549563 2.47443 0.5703614 0.0000000 1.236196 0.0000000 0.6206861 6.961387 0.03346667 0.00000000 0.07373333 0.07373333 0.41328345 0.03895578 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000109586 E001 4.7252309 0.0413497205 5.325903e-01 6.649301e-01 4 173168790 173168798 9 + 0.618 0.769 0.627
ENSG00000109586 E002 7.0803960 0.1146022925 6.852933e-01 7.880659e-01 4 173168799 173168810 12 + 0.768 0.883 0.452
ENSG00000109586 E003 47.9813673 0.0342245668 5.063628e-01 6.420214e-01 4 173168811 173168961 151 + 1.568 1.543 -0.085
ENSG00000109586 E004 0.2934659 0.0291334325 2.195451e-01   4 173224373 173224419 47 + 0.054 0.256 2.614
ENSG00000109586 E005 134.6802143 0.0078523778 4.095697e-06 2.970815e-05 4 173247980 173248440 461 + 2.035 1.805 -0.776
ENSG00000109586 E006 0.0000000       4 173282435 173282470 36 +      
ENSG00000109586 E007 26.4952629 0.0009597518 5.947474e-03 1.847009e-02 4 173292108 173292130 23 + 1.346 1.117 -0.808
ENSG00000109586 E008 59.8157707 0.0004256297 1.553403e-03 5.809070e-03 4 173292131 173292274 144 + 1.679 1.522 -0.537
ENSG00000109586 E009 63.6836914 0.0016221404 2.688219e-02 6.574939e-02 4 173295396 173295526 131 + 1.698 1.607 -0.308
ENSG00000109586 E010 1.9272640 0.0073272053 7.186831e-02 1.464523e-01 4 173295527 173295760 234 + 0.433 0.000 -11.106
ENSG00000109586 E011 45.9546805 0.0020833570 2.266107e-01 3.583522e-01 4 173295764 173295843 80 + 1.549 1.511 -0.130
ENSG00000109586 E012 22.1043624 0.0008506313 1.128938e-01 2.097708e-01 4 173297795 173297977 183 + 1.257 1.143 -0.406
ENSG00000109586 E013 0.9578041 0.0130539534 9.515476e-01 9.736759e-01 4 173297978 173298035 58 + 0.219 0.257 0.296
ENSG00000109586 E014 1.4811342 0.0101520533 1.901485e-01 3.139656e-01 4 173298036 173298114 79 + 0.252 0.534 1.618
ENSG00000109586 E015 56.9499180 0.0004140116 8.318283e-01 8.946051e-01 4 173298115 173298297 183 + 1.623 1.686 0.214
ENSG00000109586 E016 0.7490443 0.0907667174 4.694951e-01 6.087249e-01 4 173298298 173298371 74 + 0.220 0.000 -9.365
ENSG00000109586 E017 57.6451767 0.0036243208 2.958289e-02 7.113975e-02 4 173302047 173302164 118 + 1.656 1.552 -0.353
ENSG00000109586 E018 43.3824254 0.0029690036 2.964230e-02 7.126542e-02 4 173303996 173304018 23 + 1.538 1.415 -0.422
ENSG00000109586 E019 58.2489792 0.0014133310 3.952395e-02 9.014910e-02 4 173304019 173304118 100 + 1.657 1.572 -0.291
ENSG00000109586 E020 95.4722159 0.0017202943 1.683845e-01 2.860801e-01 4 173313958 173314176 219 + 1.858 1.838 -0.068
ENSG00000109586 E021 0.5922303 0.0179911728 6.081871e-01 7.280008e-01 4 173315841 173317633 1793 + 0.144 0.256 1.030
ENSG00000109586 E022 67.4601943 0.0004113334 1.402503e-02 3.828199e-02 4 173317634 173317732 99 + 1.721 1.624 -0.329
ENSG00000109586 E023 66.2803541 0.0003889070 5.780459e-03 1.803479e-02 4 173318431 173318559 129 + 1.717 1.599 -0.402
ENSG00000109586 E024 0.1515154 0.0422424284 1.000000e+00   4 173318560 173318660 101 + 0.054 0.000 -7.343
ENSG00000109586 E025 483.0519371 0.0033102069 2.420033e-19 1.437797e-17 4 173321580 173323967 2388 + 2.500 2.757 0.855