ENSG00000109576

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000337664 ENSG00000109576 HEK293_OSMI2_2hA HEK293_TMG_2hB AADAT protein_coding protein_coding 7.294246 5.661387 10.73721 0.1542719 0.1991063 0.9221882 3.5625393 2.2724968 4.820083 0.64280384 0.5034554 1.0814352 0.49452083 0.40353333 0.4497333 0.04620000 8.858056e-01 1.543147e-08 FALSE TRUE
ENST00000353187 ENSG00000109576 HEK293_OSMI2_2hA HEK293_TMG_2hB AADAT protein_coding protein_coding 7.294246 5.661387 10.73721 0.1542719 0.1991063 0.9221882 0.7473348 0.8759519 1.080653 0.87595194 0.5923455 0.2998922 0.09859583 0.14896667 0.1004000 -0.04856667 7.019250e-01 1.543147e-08 FALSE TRUE
ENST00000505906 ENSG00000109576 HEK293_OSMI2_2hA HEK293_TMG_2hB AADAT protein_coding retained_intron 7.294246 5.661387 10.73721 0.1542719 0.1991063 0.9221882 0.9737120 0.1312272 1.777277 0.02344324 0.2095915 3.6616728 0.12259583 0.02333333 0.1649333 0.14160000 1.543147e-08 1.543147e-08 FALSE TRUE
MSTRG.25726.9 ENSG00000109576 HEK293_OSMI2_2hA HEK293_TMG_2hB AADAT protein_coding   7.294246 5.661387 10.73721 0.1542719 0.1991063 0.9221882 1.9092840 2.1071268 2.934294 0.05424024 0.1258955 0.4758140 0.27056250 0.37300000 0.2730667 -0.09993333 4.970956e-02 1.543147e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000109576 E001 0.6245948 0.1236750790 3.725212e-02 8.595459e-02 4 170060222 170060228 7 - 0.000 0.358 11.442
ENSG00000109576 E002 83.9062565 0.0014291630 2.868488e-07 2.665796e-06 4 170060229 170060969 741 - 1.828 2.033 0.689
ENSG00000109576 E003 33.9891983 0.0007144416 1.310820e-01 2.356529e-01 4 170061892 170061993 102 - 1.502 1.593 0.312
ENSG00000109576 E004 37.5288937 0.0320078774 7.681874e-01 8.502320e-01 4 170064719 170064825 107 - 1.563 1.618 0.187
ENSG00000109576 E005 33.4565908 0.0186019162 8.100216e-01 8.794150e-01 4 170066414 170066478 65 - 1.541 1.536 -0.020
ENSG00000109576 E006 34.9650112 0.0006925885 3.734464e-01 5.179004e-01 4 170067327 170067388 62 - 1.578 1.528 -0.170
ENSG00000109576 E007 39.2079931 0.0006120754 7.344847e-01 8.254195e-01 4 170068591 170068687 97 - 1.595 1.616 0.072
ENSG00000109576 E008 40.5759977 0.0066191500 5.086664e-01 6.440456e-01 4 170069148 170069230 83 - 1.630 1.585 -0.152
ENSG00000109576 E009 5.0650104 0.0031578033 1.137847e-03 4.430022e-03 4 170070477 170070586 110 - 0.920 0.428 -2.122
ENSG00000109576 E010 30.0220490 0.0007005683 2.328931e-01 3.658662e-01 4 170070587 170070618 32 - 1.519 1.445 -0.254
ENSG00000109576 E011 26.1608076 0.0008085061 1.703969e-01 2.886810e-01 4 170070619 170070652 34 - 1.466 1.374 -0.317
ENSG00000109576 E012 26.8586494 0.0008068201 5.216232e-03 1.651927e-02 4 170073136 170073160 25 - 1.509 1.317 -0.664
ENSG00000109576 E013 38.0347902 0.0041251626 7.544444e-02 1.522316e-01 4 170073161 170073249 89 - 1.627 1.513 -0.390
ENSG00000109576 E014 34.3846091 0.0006363552 7.211750e-02 1.468622e-01 4 170073250 170073345 96 - 1.583 1.477 -0.365
ENSG00000109576 E015 17.0844080 0.0012733182 4.293818e-05 2.457556e-04 4 170075309 170075461 153 - 1.074 1.411 1.192
ENSG00000109576 E016 41.2400803 0.0006782820 2.431102e-01 3.778406e-01 4 170078509 170078583 75 - 1.589 1.654 0.221
ENSG00000109576 E017 61.3346079 0.0004604900 1.865380e-01 3.094028e-01 4 170087116 170087248 133 - 1.765 1.825 0.203
ENSG00000109576 E018 80.4841079 0.0004269418 9.948974e-01 1.000000e+00 4 170088396 170088564 169 - 1.905 1.907 0.006
ENSG00000109576 E019 0.3666179 0.0273389439 7.089973e-01 8.065027e-01 4 170089261 170089611 351 - 0.098 0.153 0.739
ENSG00000109576 E020 1.2513691 0.5665678662 9.170267e-01 9.515925e-01 4 170089612 170089623 12 - 0.302 0.374 0.444
ENSG00000109576 E021 46.9489060 0.0005439529 9.314056e-02 1.800329e-01 4 170089624 170089736 113 - 1.709 1.625 -0.286
ENSG00000109576 E022 26.7041808 0.0364819889 3.105281e-01 4.529355e-01 4 170089737 170090001 265 - 1.477 1.366 -0.382
ENSG00000109576 E023 14.0244683 0.0012274458 1.566516e-02 4.199106e-02 4 170090144 170090161 18 - 1.253 1.028 -0.807
ENSG00000109576 E024 14.4953841 0.0012312995 8.282903e-02 1.639797e-01 4 170090162 170090224 63 - 1.247 1.091 -0.554
ENSG00000109576 E025 2.2725870 0.0544458784 7.490644e-01 8.361203e-01 4 170090225 170090387 163 - 0.546 0.489 -0.273
ENSG00000109576 E026 0.0000000       4 170090418 170090531 114 -      
ENSG00000109576 E027 0.0000000       4 170091594 170091699 106 -