ENSG00000109572

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000347613 ENSG00000109572 HEK293_OSMI2_2hA HEK293_TMG_2hB CLCN3 protein_coding protein_coding 24.95542 5.176071 33.87199 0.2475213 0.4442577 2.707805 3.075461 1.4303027 4.750480 0.34348378 0.32264368 1.724735 0.16064583 0.27346667 0.14050000 -0.13296667 7.842434e-02 2.026875e-33 FALSE TRUE
ENST00000507875 ENSG00000109572 HEK293_OSMI2_2hA HEK293_TMG_2hB CLCN3 protein_coding protein_coding 24.95542 5.176071 33.87199 0.2475213 0.4442577 2.707805 2.707084 0.0000000 5.693797 0.00000000 0.30114849 9.155779 0.07977917 0.00000000 0.16800000 0.16800000 1.535730e-20 2.026875e-33 FALSE TRUE
ENST00000511092 ENSG00000109572 HEK293_OSMI2_2hA HEK293_TMG_2hB CLCN3 protein_coding protein_coding 24.95542 5.176071 33.87199 0.2475213 0.4442577 2.707805 6.371315 0.0000000 8.640894 0.00000000 0.21152043 9.756705 0.16533333 0.00000000 0.25503333 0.25503333 2.026875e-33 2.026875e-33 FALSE FALSE
ENST00000513761 ENSG00000109572 HEK293_OSMI2_2hA HEK293_TMG_2hB CLCN3 protein_coding protein_coding 24.95542 5.176071 33.87199 0.2475213 0.4442577 2.707805 7.872735 3.0079425 11.516302 0.27884658 0.37875676 1.933292 0.42548750 0.58390000 0.33983333 -0.24406667 3.374475e-03 2.026875e-33 FALSE TRUE
MSTRG.25723.9 ENSG00000109572 HEK293_OSMI2_2hA HEK293_TMG_2hB CLCN3 protein_coding   24.95542 5.176071 33.87199 0.2475213 0.4442577 2.707805 1.867508 0.2298258 2.217187 0.08264558 0.05913619 3.215164 0.06719583 0.04343333 0.06546667 0.02203333 4.245339e-01 2.026875e-33 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000109572 E001 0.0000000       4 169612633 169612677 45 +      
ENSG00000109572 E002 2.3112716 0.0807598923 5.925792e-01 7.151106e-01 4 169620526 169620528 3 + 0.469 0.384 -0.450
ENSG00000109572 E003 6.6646893 0.0268027304 1.848102e-01 3.072338e-01 4 169620529 169620551 23 + 0.835 0.657 -0.723
ENSG00000109572 E004 16.5050536 0.0062820952 3.422935e-01 4.862951e-01 4 169620552 169620577 26 + 1.161 1.115 -0.163
ENSG00000109572 E005 29.9992523 0.0012597787 3.115406e-02 7.419941e-02 4 169620578 169620595 18 + 1.420 1.303 -0.407
ENSG00000109572 E006 76.8884964 0.0017278455 2.361066e-03 8.341511e-03 4 169620596 169620682 87 + 1.820 1.715 -0.354
ENSG00000109572 E007 87.5412927 0.0029327496 6.040247e-03 1.871617e-02 4 169620683 169620751 69 + 1.872 1.786 -0.293
ENSG00000109572 E008 67.6969479 0.0003774445 1.551912e-02 4.167035e-02 4 169620752 169620771 20 + 1.758 1.691 -0.229
ENSG00000109572 E009 62.2573879 0.0003689068 1.466543e-01 2.571377e-01 4 169620772 169620788 17 + 1.713 1.697 -0.055
ENSG00000109572 E010 152.4748424 0.0012136427 2.949812e-03 1.011649e-02 4 169620789 169621063 275 + 2.104 2.052 -0.176
ENSG00000109572 E011 5.9873374 0.0027905486 8.443231e-01 9.031109e-01 4 169630165 169630335 171 + 0.740 0.823 0.332
ENSG00000109572 E012 68.3028180 0.0004107951 4.244765e-03 1.382689e-02 4 169635913 169635982 70 + 1.765 1.672 -0.317
ENSG00000109572 E013 100.9311202 0.0033630916 2.003337e-02 5.155976e-02 4 169635983 169636088 106 + 1.925 1.865 -0.202
ENSG00000109572 E014 1.5834456 0.0088175289 9.843509e-01 9.942913e-01 4 169638597 169638742 146 + 0.342 0.383 0.239
ENSG00000109572 E015 0.0000000       4 169642708 169643168 461 +      
ENSG00000109572 E016 6.9275665 0.0035740341 2.331255e-01 3.661280e-01 4 169660062 169660448 387 + 0.845 0.719 -0.500
ENSG00000109572 E017 68.6423693 0.0204853318 4.232504e-02 9.531587e-02 4 169680050 169680067 18 + 1.771 1.651 -0.407
ENSG00000109572 E018 147.7826778 0.0002661030 2.098252e-04 1.005865e-03 4 169680068 169680207 140 + 2.094 2.021 -0.246
ENSG00000109572 E019 0.4449813 0.0213376890 5.615291e-01 6.893128e-01 4 169680379 169680731 353 + 0.114 0.232 1.236
ENSG00000109572 E020 140.8514261 0.0002502150 3.233844e-03 1.095490e-02 4 169687658 169687757 100 + 2.069 2.024 -0.153
ENSG00000109572 E021 169.6879670 0.0002121116 6.011959e-05 3.320160e-04 4 169689043 169689230 188 + 2.155 2.081 -0.247
ENSG00000109572 E022 95.4331710 0.0010605351 3.703778e-03 1.230805e-02 4 169690530 169690652 123 + 1.908 1.833 -0.252
ENSG00000109572 E023 143.9588238 0.0006152421 1.680344e-04 8.267612e-04 4 169692114 169692320 207 + 2.085 2.003 -0.274
ENSG00000109572 E024 57.1656312 0.0004075330 5.924429e-03 1.841060e-02 4 169695612 169695630 19 + 1.694 1.593 -0.343
ENSG00000109572 E025 89.7467212 0.0003349172 3.587582e-02 8.334130e-02 4 169695631 169695692 62 + 1.872 1.838 -0.114
ENSG00000109572 E026 94.4991924 0.0003069984 3.372749e-01 4.811497e-01 4 169697189 169697279 91 + 1.882 1.904 0.074
ENSG00000109572 E027 93.9201041 0.0003141265 4.845468e-01 6.225075e-01 4 169697280 169697360 81 + 1.878 1.912 0.113
ENSG00000109572 E028 236.3982071 0.0001989720 1.053005e-02 3.004484e-02 4 169697361 169697734 374 + 2.284 2.276 -0.025
ENSG00000109572 E029 140.3168494 0.0002494822 5.243165e-01 6.578687e-01 4 169703998 169704184 187 + 2.049 2.091 0.141
ENSG00000109572 E030 251.5040752 0.0001837991 8.549181e-02 1.681967e-01 4 169706868 169707266 399 + 2.286 2.396 0.368
ENSG00000109572 E031 201.2134534 0.0009843678 5.781488e-01 7.033009e-01 4 169713079 169713295 217 + 2.203 2.250 0.155
ENSG00000109572 E032 22.3866471 0.0081605696 6.212259e-01 7.382162e-01 4 169717792 169717867 76 + 1.261 1.371 0.387
ENSG00000109572 E033 5.1550401 0.0216308662 4.701015e-01 6.093141e-01 4 169717868 169717934 67 + 0.728 0.656 -0.302
ENSG00000109572 E034 6.2654158 0.0455790191 7.682628e-01 8.502806e-01 4 169717935 169718101 167 + 0.764 0.864 0.395
ENSG00000109572 E035 912.8070916 0.0057773605 1.271813e-12 3.066969e-11 4 169719907 169723673 3767 + 2.797 3.069 0.904