ENSG00000109501

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000226760 ENSG00000109501 HEK293_OSMI2_2hA HEK293_TMG_2hB WFS1 protein_coding protein_coding 23.79159 34.53229 15.7783 1.669417 0.5553142 -1.129507 12.702932 14.532901 10.137054 2.312590 0.05390691 -0.5192542 0.5491792 0.4188000 0.64406667 0.22526667 0.02391430 0.00439669 FALSE TRUE
ENST00000503569 ENSG00000109501 HEK293_OSMI2_2hA HEK293_TMG_2hB WFS1 protein_coding protein_coding 23.79159 34.53229 15.7783 1.669417 0.5553142 -1.129507 2.697443 2.171214 2.023028 0.297597 0.43900256 -0.1015013 0.1215292 0.0640000 0.12723333 0.06323333 0.13903376 0.00439669 FALSE TRUE
ENST00000506362 ENSG00000109501 HEK293_OSMI2_2hA HEK293_TMG_2hB WFS1 protein_coding protein_coding 23.79159 34.53229 15.7783 1.669417 0.5553142 -1.129507 3.232379 8.911873 2.068508 1.267480 0.22134968 -2.1017982 0.1206208 0.2569000 0.13076667 -0.12613333 0.00439669 0.00439669 FALSE TRUE
ENST00000513395 ENSG00000109501 HEK293_OSMI2_2hA HEK293_TMG_2hB WFS1 protein_coding retained_intron 23.79159 34.53229 15.7783 1.669417 0.5553142 -1.129507 3.442033 6.539181 1.103164 1.131365 0.23032839 -2.5566483 0.1410000 0.1906667 0.06926667 -0.12140000 0.01410532 0.00439669 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000109501 E001 0.8062000 0.1081202264 7.151563e-01 8.111570e-01 4 6269849 6269849 1 + 0.278 0.232 -0.351
ENSG00000109501 E002 1.5038476 0.2974715219 7.104839e-01 8.076556e-01 4 6269850 6269859 10 + 0.447 0.340 -0.594
ENSG00000109501 E003 6.6633939 0.0025081820 2.595849e-01 3.970072e-01 4 6269860 6269867 8 + 0.913 0.823 -0.347
ENSG00000109501 E004 55.6887119 0.0093524467 9.339210e-02 1.804197e-01 4 6269868 6269976 109 + 1.751 1.697 -0.183
ENSG00000109501 E005 52.8004605 0.0007635330 1.396686e-01 2.475631e-01 4 6269977 6270014 38 + 1.703 1.683 -0.068
ENSG00000109501 E006 0.0000000       4 6277309 6277450 142 +      
ENSG00000109501 E007 33.1638129 0.0013491678 2.563752e-01 3.933263e-01 4 6277451 6277454 4 + 1.505 1.487 -0.062
ENSG00000109501 E008 45.2542914 0.0005280649 3.395630e-01 4.834963e-01 4 6277455 6277465 11 + 1.622 1.626 0.012
ENSG00000109501 E009 77.7283189 0.0058582601 6.287871e-02 1.315092e-01 4 6277466 6277521 56 + 1.886 1.843 -0.145
ENSG00000109501 E010 112.6647300 0.0095819289 8.923721e-03 2.608948e-02 4 6277522 6277647 126 + 2.076 1.989 -0.292
ENSG00000109501 E011 57.1581366 0.0009062600 1.659795e-03 6.153368e-03 4 6277648 6277656 9 + 1.793 1.695 -0.332
ENSG00000109501 E012 67.5356180 0.0008738568 1.495635e-03 5.621563e-03 4 6277657 6277687 31 + 1.857 1.769 -0.298
ENSG00000109501 E013 0.0000000       4 6282793 6283277 485 +      
ENSG00000109501 E014 98.0679163 0.0053833568 1.736438e-04 8.511334e-04 4 6287093 6287175 83 + 2.042 1.914 -0.430
ENSG00000109501 E015 4.2320940 0.0255591541 8.550040e-01 9.103259e-01 4 6287176 6288129 954 + 0.662 0.681 0.079
ENSG00000109501 E016 1.6584824 0.0174785836 4.315564e-01 5.741084e-01 4 6288487 6288986 500 + 0.278 0.459 1.065
ENSG00000109501 E017 142.1070770 0.0014717113 3.200582e-05 1.891033e-04 4 6288987 6289131 145 + 2.175 2.088 -0.293
ENSG00000109501 E018 0.1817044 0.0398682011 1.000000e+00   4 6289132 6289223 92 + 0.000 0.092 8.182
ENSG00000109501 E019 176.4197672 0.0002138748 2.307099e-04 1.094653e-03 4 6291197 6291354 158 + 2.241 2.195 -0.152
ENSG00000109501 E020 75.3353007 0.0009325595 5.111231e-01 6.462269e-01 4 6291355 6291367 13 + 1.824 1.851 0.094
ENSG00000109501 E021 1.0286894 0.0121989077 4.154640e-01 5.588419e-01 4 6291368 6291652 285 + 0.161 0.338 1.390
ENSG00000109501 E022 118.7421023 0.0034859550 5.206304e-01 6.545827e-01 4 6291917 6291997 81 + 2.017 2.046 0.098
ENSG00000109501 E023 20.8939115 0.0312239914 2.097765e-01 3.382767e-01 4 6294771 6295004 234 + 1.148 1.361 0.752
ENSG00000109501 E024 11.4911397 0.0135447132 7.575324e-01 8.423316e-01 4 6295005 6295040 36 + 1.000 1.089 0.327
ENSG00000109501 E025 179.9970901 0.0031096519 1.541483e-01 2.673062e-01 4 6295041 6295189 149 + 2.212 2.218 0.019
ENSG00000109501 E026 182.7810673 0.0011118391 3.117611e-03 1.061201e-02 4 6300657 6300796 140 + 2.245 2.212 -0.110
ENSG00000109501 E027 1926.8279054 0.0028252672 1.126230e-09 1.653961e-08 4 6300797 6303265 2469 + 3.140 3.287 0.488