ENSG00000109381

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000358635 ENSG00000109381 HEK293_OSMI2_2hA HEK293_TMG_2hB ELF2 protein_coding protein_coding 12.46657 3.992628 18.5252 0.1068592 0.8413077 2.211248 2.3069671 0.88174125 4.7996065 0.44403263 1.1415261 2.431222 0.20529583 0.22463333 0.26463333 0.04000000 8.763036e-01 6.307345e-17 FALSE TRUE
ENST00000379549 ENSG00000109381 HEK293_OSMI2_2hA HEK293_TMG_2hB ELF2 protein_coding protein_coding 12.46657 3.992628 18.5252 0.1068592 0.8413077 2.211248 1.1614379 0.80055179 0.8938619 0.33621719 0.3428925 0.157198 0.09388333 0.20113333 0.04686667 -0.15426667 2.407879e-01 6.307345e-17 FALSE TRUE
ENST00000379550 ENSG00000109381 HEK293_OSMI2_2hA HEK293_TMG_2hB ELF2 protein_coding protein_coding 12.46657 3.992628 18.5252 0.1068592 0.8413077 2.211248 2.5868830 1.06951238 2.5409497 0.55485779 0.9460500 1.240655 0.24170833 0.26066667 0.13440000 -0.12626667 9.119023e-01 6.307345e-17 FALSE TRUE
ENST00000394235 ENSG00000109381 HEK293_OSMI2_2hA HEK293_TMG_2hB ELF2 protein_coding protein_coding 12.46657 3.992628 18.5252 0.1068592 0.8413077 2.211248 0.2238441 0.41477718 0.1180401 0.09992833 0.1180401 -1.730111 0.03787083 0.10370000 0.00660000 -0.09710000 1.920614e-02 6.307345e-17 FALSE TRUE
ENST00000510408 ENSG00000109381 HEK293_OSMI2_2hA HEK293_TMG_2hB ELF2 protein_coding protein_coding 12.46657 3.992628 18.5252 0.1068592 0.8413077 2.211248 1.0282045 0.07941461 1.9090143 0.07941461 0.6692124 4.423711 0.05313750 0.01920000 0.10046667 0.08126667 1.549906e-01 6.307345e-17 FALSE TRUE
MSTRG.25481.10 ENSG00000109381 HEK293_OSMI2_2hA HEK293_TMG_2hB ELF2 protein_coding   12.46657 3.992628 18.5252 0.1068592 0.8413077 2.211248 1.1687440 0.18087787 1.5733631 0.06139814 0.1498596 3.052270 0.08711667 0.04603333 0.08570000 0.03966667 2.482875e-01 6.307345e-17 FALSE TRUE
MSTRG.25481.3 ENSG00000109381 HEK293_OSMI2_2hA HEK293_TMG_2hB ELF2 protein_coding   12.46657 3.992628 18.5252 0.1068592 0.8413077 2.211248 2.7837144 0.00000000 4.5257497 0.00000000 0.2765506 8.825197 0.17730833 0.00000000 0.24613333 0.24613333 6.307345e-17 6.307345e-17 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000109381 E001 0.1515154 0.0430092677 1.000000e+00   4 139027993 139028111 119 - 0.065 0.001 -6.930
ENSG00000109381 E002 1.9240392 0.0071661279 3.128373e-01 4.553641e-01 4 139028112 139028349 238 - 0.359 0.560 1.034
ENSG00000109381 E003 1.3328556 0.0097898972 4.527418e-01 5.935598e-01 4 139048281 139048300 20 - 0.359 0.220 -0.967
ENSG00000109381 E004 1.6326642 0.0087227455 8.352523e-01 8.969178e-01 4 139048301 139048338 38 - 0.389 0.365 -0.137
ENSG00000109381 E005 0.5138669 0.0204107910 5.891270e-01 7.122195e-01 4 139057220 139057264 45 - 0.121 0.220 1.036
ENSG00000109381 E006 5.4147120 0.0045010753 2.326036e-01 3.655508e-01 4 139057265 139057716 452 - 0.687 0.880 0.772
ENSG00000109381 E007 2.8346112 0.0061252185 3.849634e-03 1.271956e-02 4 139057717 139057854 138 - 0.359 0.841 2.205
ENSG00000109381 E008 2.2216551 0.0188365546 2.068975e-03 7.438298e-03 4 139057855 139057878 24 - 0.256 0.798 2.713
ENSG00000109381 E009 109.3854157 0.0120279564 1.384165e-12 3.313025e-11 4 139057879 139058655 777 - 1.816 2.271 1.525
ENSG00000109381 E010 40.0378375 0.0005702711 7.889166e-01 8.648883e-01 4 139058656 139058668 13 - 1.537 1.547 0.034
ENSG00000109381 E011 64.0224051 0.0003724747 2.222631e-01 3.531136e-01 4 139058669 139058718 50 - 1.714 1.803 0.300
ENSG00000109381 E012 307.3879033 0.0005398635 3.944742e-01 5.383009e-01 4 139058719 139059607 889 - 2.411 2.420 0.029
ENSG00000109381 E013 112.3397973 0.0019896942 3.656858e-01 5.099875e-01 4 139060324 139060600 277 - 1.981 1.970 -0.040
ENSG00000109381 E014 68.2240883 0.0003569971 3.977255e-02 9.060366e-02 4 139060601 139060674 74 - 1.782 1.702 -0.268
ENSG00000109381 E015 47.8344347 0.0004962903 1.107405e-02 3.134445e-02 4 139061865 139061866 2 - 1.640 1.505 -0.461
ENSG00000109381 E016 63.7349887 0.0004346286 2.455524e-02 6.096157e-02 4 139061867 139061936 70 - 1.756 1.661 -0.321
ENSG00000109381 E017 72.8968280 0.0003880784 7.721119e-02 1.550205e-01 4 139061937 139062057 121 - 1.806 1.746 -0.205
ENSG00000109381 E018 4.4285573 0.0235817139 6.637443e-01 7.717361e-01 4 139066010 139067683 1674 - 0.687 0.633 -0.229
ENSG00000109381 E019 58.6186157 0.0004565410 4.571920e-02 1.015198e-01 4 139067684 139067770 87 - 1.714 1.629 -0.292
ENSG00000109381 E020 79.6322835 0.0003241887 5.004447e-02 1.092519e-01 4 139071866 139072003 138 - 1.846 1.780 -0.222
ENSG00000109381 E021 23.1350942 0.0008232690 7.912184e-04 3.227845e-03 4 139072004 139072039 36 - 1.362 1.062 -1.064
ENSG00000109381 E022 0.5869198 0.1751771906 4.478975e-01 5.892522e-01 4 139072040 139072220 181 - 0.215 0.000 -10.430
ENSG00000109381 E023 72.4501435 0.0017462430 3.969939e-02 9.046431e-02 4 139073454 139073567 114 - 1.808 1.725 -0.280
ENSG00000109381 E024 0.5879639 0.0229338282 8.326817e-01 8.951653e-01 4 139073568 139073719 152 - 0.171 0.220 0.447
ENSG00000109381 E025 27.7299723 0.0008304990 3.338835e-01 4.776504e-01 4 139084133 139084496 364 - 1.394 1.344 -0.175
ENSG00000109381 E026 2.7175511 0.0076032951 3.570176e-04 1.607394e-03 4 139101591 139102353 763 - 0.293 0.880 2.772
ENSG00000109381 E027 7.4663197 0.0034114374 2.598265e-01 3.972861e-01 4 139116649 139116751 103 - 0.811 0.981 0.648
ENSG00000109381 E028 3.6436722 0.2110175304 6.901183e-01 7.918984e-01 4 139116752 139116807 56 - 0.554 0.711 0.680
ENSG00000109381 E029 1.1426420 0.4261598350 4.313977e-01 5.739522e-01 4 139117829 139117950 122 - 0.216 0.477 1.629
ENSG00000109381 E030 43.1173536 0.0114392217 5.214216e-01 6.553079e-01 4 139125164 139125329 166 - 1.578 1.553 -0.084
ENSG00000109381 E031 2.3198150 0.0080221429 1.983927e-01 3.241987e-01 4 139136771 139137629 859 - 0.389 0.633 1.188
ENSG00000109381 E032 50.0095362 0.0004946786 3.347306e-01 4.784635e-01 4 139137630 139137867 238 - 1.638 1.608 -0.103
ENSG00000109381 E033 21.5957841 0.0116646035 8.224872e-01 8.880831e-01 4 139139413 139139497 85 - 1.275 1.277 0.005
ENSG00000109381 E034 18.5118599 0.0013312484 9.000668e-01 9.402482e-01 4 139176967 139177218 252 - 1.212 1.226 0.050