ENSG00000109320

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000226574 ENSG00000109320 HEK293_OSMI2_2hA HEK293_TMG_2hB NFKB1 protein_coding protein_coding 11.00425 10.70649 11.30775 0.4119398 0.3684709 0.07875514 4.179612 3.0510907 4.3079040 0.6182745 0.5242644 0.4962854 0.3751000 0.28146667 0.38280000 0.1013333 0.500085933 0.005816239 FALSE TRUE
ENST00000394820 ENSG00000109320 HEK293_OSMI2_2hA HEK293_TMG_2hB NFKB1 protein_coding protein_coding 11.00425 10.70649 11.30775 0.4119398 0.3684709 0.07875514 1.717587 0.7236716 2.9611699 0.2071116 0.5148775 2.0178248 0.1554542 0.06876667 0.26363333 0.1948667 0.005816239 0.005816239 FALSE TRUE
ENST00000652569 ENSG00000109320 HEK293_OSMI2_2hA HEK293_TMG_2hB NFKB1 protein_coding nonsense_mediated_decay 11.00425 10.70649 11.30775 0.4119398 0.3684709 0.07875514 1.981079 2.4900387 0.6088526 1.2462753 0.6088526 -2.0142827 0.1933250 0.23036667 0.05066667 -0.1797000 0.455081185 0.005816239 FALSE TRUE
MSTRG.25244.6 ENSG00000109320 HEK293_OSMI2_2hA HEK293_TMG_2hB NFKB1 protein_coding   11.00425 10.70649 11.30775 0.4119398 0.3684709 0.07875514 2.939467 4.3726049 3.1517524 1.0145411 0.2825556 -0.4710643 0.2595417 0.41276667 0.27970000 -0.1330667 0.545588020 0.005816239 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000109320 E001 5.2971134 0.2035085170 2.287765e-01 3.609917e-01 4 102501331 102501358 28 + 0.926 0.639 -1.148
ENSG00000109320 E002 7.6983872 0.0795873988 5.585032e-02 1.194302e-01 4 102501359 102501404 46 + 1.078 0.754 -1.229
ENSG00000109320 E003 7.8048381 0.0374874176 8.327792e-03 2.461195e-02 4 102501405 102501454 50 + 1.100 0.726 -1.426
ENSG00000109320 E004 5.9882809 0.0028295766 9.478916e-04 3.781009e-03 4 102501455 102501471 17 + 1.014 0.598 -1.654
ENSG00000109320 E005 9.2753552 0.0022665348 9.701913e-08 9.875340e-07 4 102501472 102501617 146 + 1.233 0.633 -2.288
ENSG00000109320 E006 27.2756507 0.0007728038 4.150582e-07 3.731210e-06 4 102501618 102501788 171 + 1.598 1.274 -1.119
ENSG00000109320 E007 0.0000000       4 102501898 102502167 270 +      
ENSG00000109320 E008 0.1451727 0.0430032198 4.898372e-01   4 102503375 102503490 116 + 0.121 0.000 -11.275
ENSG00000109320 E009 3.9031824 0.1403334673 9.306224e-01 9.603622e-01 4 102510880 102510949 70 + 0.658 0.703 0.189
ENSG00000109320 E010 29.9232942 0.0058756413 5.440075e-04 2.324588e-03 4 102525512 102525557 46 + 1.601 1.363 -0.819
ENSG00000109320 E011 37.0139184 0.0006010635 1.221892e-04 6.238278e-04 4 102529836 102529879 44 + 1.681 1.477 -0.698
ENSG00000109320 E012 40.7763297 0.0005645173 7.750571e-09 9.752557e-08 4 102529880 102529914 35 + 1.761 1.457 -1.034
ENSG00000109320 E013 16.3058319 0.0077078218 1.174613e-02 3.292841e-02 4 102533845 102533847 3 + 1.347 1.129 -0.766
ENSG00000109320 E014 39.4133833 0.0005781170 3.103740e-07 2.862679e-06 4 102533848 102533885 38 + 1.733 1.462 -0.924
ENSG00000109320 E015 0.0000000       4 102537587 102537598 12 +      
ENSG00000109320 E016 0.0000000       4 102537599 102537628 30 +      
ENSG00000109320 E017 0.1515154 0.0423951447 4.892228e-01   4 102537629 102537857 229 + 0.121 0.000 -11.276
ENSG00000109320 E018 68.5251948 0.0003809825 2.653917e-07 2.483338e-06 4 102537858 102537956 99 + 1.939 1.735 -0.688
ENSG00000109320 E019 0.0000000       4 102557105 102557206 102 +      
ENSG00000109320 E020 95.0356008 0.0009682473 1.394011e-05 8.957711e-05 4 102566987 102567135 149 + 2.057 1.905 -0.509
ENSG00000109320 E021 92.9634260 0.0003266971 1.084170e-03 4.249976e-03 4 102576876 102577039 164 + 2.026 1.922 -0.349
ENSG00000109320 E022 0.1451727 0.0430032198 4.898372e-01   4 102577714 102577863 150 + 0.121 0.000 -11.275
ENSG00000109320 E023 0.1451727 0.0430032198 4.898372e-01   4 102577864 102577975 112 + 0.121 0.000 -11.275
ENSG00000109320 E024 0.2944980 0.3538186317 2.850668e-01   4 102577976 102578880 905 + 0.216 0.000 -12.275
ENSG00000109320 E025 83.4053954 0.0003329473 4.803419e-01 6.186307e-01 4 102578881 102579039 159 + 1.936 1.924 -0.040
ENSG00000109320 E026 66.9335553 0.0020784082 9.017676e-01 9.414072e-01 4 102580535 102580639 105 + 1.826 1.848 0.075
ENSG00000109320 E027 0.4355181 0.6116968658 2.767851e-01 4.162619e-01 4 102582573 102582634 62 + 0.292 0.000 -12.851
ENSG00000109320 E028 64.0895409 0.0003868639 2.144431e-01 3.438040e-01 4 102582866 102582957 92 + 1.775 1.844 0.233
ENSG00000109320 E029 78.2759587 0.0032083981 9.993832e-02 1.904002e-01 4 102584682 102584820 139 + 1.844 1.934 0.302
ENSG00000109320 E030 0.4031496 0.0252507417 2.001033e-01 3.263758e-01 4 102593249 102593424 176 + 0.000 0.220 12.070
ENSG00000109320 E031 86.4572717 0.0004089300 6.886924e-01 7.907747e-01 4 102593425 102593568 144 + 1.923 1.952 0.099
ENSG00000109320 E032 62.4960473 0.0006091941 6.071584e-01 7.272059e-01 4 102594892 102594981 90 + 1.809 1.801 -0.028
ENSG00000109320 E033 123.9360313 0.0016793924 5.653268e-02 1.206496e-01 4 102596138 102596332 195 + 2.126 2.071 -0.184
ENSG00000109320 E034 0.0000000       4 102596831 102596872 42 +      
ENSG00000109320 E035 102.4989045 0.0002666288 2.274316e-02 5.721896e-02 4 102597520 102597661 142 + 2.049 1.986 -0.213
ENSG00000109320 E036 92.7473582 0.0010503022 2.755808e-02 6.712778e-02 4 102600895 102601009 115 + 2.011 1.942 -0.234
ENSG00000109320 E037 123.5298370 0.0002536700 5.792214e-01 7.041716e-01 4 102606496 102606697 202 + 2.098 2.095 -0.009
ENSG00000109320 E038 101.6270010 0.0002864076 3.942289e-01 5.380915e-01 4 102607150 102607319 170 + 1.988 2.032 0.149
ENSG00000109320 E039 79.0700640 0.0003815063 2.955442e-01 4.366710e-01 4 102607649 102607751 103 + 1.873 1.929 0.188
ENSG00000109320 E040 103.2643752 0.0003370483 2.009661e-01 3.273879e-01 4 102610575 102610699 125 + 1.986 2.045 0.197
ENSG00000109320 E041 90.9341886 0.0010348087 2.034228e-02 5.220160e-02 4 102612044 102612110 67 + 1.906 2.011 0.354
ENSG00000109320 E042 142.1172918 0.0002820891 2.809323e-07 2.615192e-06 4 102612434 102612606 173 + 2.057 2.225 0.563
ENSG00000109320 E043 145.5701711 0.0002921193 6.025393e-07 5.246465e-06 4 102613425 102613581 157 + 2.071 2.233 0.543
ENSG00000109320 E044 331.1608205 0.0034866138 3.052725e-12 6.921957e-11 4 102616434 102617302 869 + 2.378 2.615 0.788