ENSG00000109270

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000226522 ENSG00000109270 HEK293_OSMI2_2hA HEK293_TMG_2hB LAMTOR3 protein_coding protein_coding 21.41351 9.289228 35.2263 1.686149 1.185931 1.921879 6.364959 5.3712509 10.012364 0.6737085 0.2519943 0.8972094 0.37043333 0.5917667 0.28503333 -0.306733333 0.0001286739 1.140798e-09 FALSE FALSE
ENST00000499666 ENSG00000109270 HEK293_OSMI2_2hA HEK293_TMG_2hB LAMTOR3 protein_coding protein_coding 21.41351 9.289228 35.2263 1.686149 1.185931 1.921879 2.036990 0.8890778 3.178111 0.1896695 0.5923901 1.8261840 0.09871667 0.0950000 0.08976667 -0.005233333 0.9267851394 1.140798e-09 FALSE FALSE
ENST00000515100 ENSG00000109270 HEK293_OSMI2_2hA HEK293_TMG_2hB LAMTOR3 protein_coding processed_transcript 21.41351 9.289228 35.2263 1.686149 1.185931 1.921879 11.423254 2.8713561 18.439986 1.0464831 1.0656346 2.6787998 0.47406667 0.2930667 0.52263333 0.229566667 0.0496802475 1.140798e-09   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000109270 E001 24.262735 0.0507105538 2.511120e-01 3.872714e-01 4 99878336 99878711 376 - 1.305 1.475 0.588
ENSG00000109270 E002 11.800220 0.0630705734 4.437706e-01 5.853587e-01 4 99878712 99878723 12 - 1.029 1.144 0.414
ENSG00000109270 E003 73.065073 0.0030812605 9.666891e-01 9.831142e-01 4 99878724 99879466 743 - 1.817 1.821 0.015
ENSG00000109270 E004 31.516714 0.0100562482 4.442160e-02 9.915136e-02 4 99879467 99879747 281 - 1.501 1.318 -0.633
ENSG00000109270 E005 10.715440 0.0209346364 4.910953e-01 6.284087e-01 4 99879748 99879810 63 - 1.042 0.945 -0.360
ENSG00000109270 E006 1.400620 0.0093166915 1.571988e-01 2.713664e-01 4 99879811 99879843 33 - 0.274 0.532 1.448
ENSG00000109270 E007 9.375972 0.0019256244 1.741668e-02 4.586004e-02 4 99879844 99879909 66 - 1.036 0.717 -1.229
ENSG00000109270 E008 100.279044 0.0003237945 1.922804e-16 7.976123e-15 4 99879910 99881096 1187 - 2.023 1.634 -1.311
ENSG00000109270 E009 10.727375 0.0016776824 5.791578e-02 1.230566e-01 4 99881097 99881206 110 - 1.076 0.846 -0.862
ENSG00000109270 E010 88.334332 0.0010191270 2.438994e-19 1.447103e-17 4 99881207 99881492 286 - 1.777 2.139 1.216
ENSG00000109270 E011 333.026783 0.0002542129 1.747201e-04 8.557668e-04 4 99881493 99881977 485 - 2.451 2.529 0.262
ENSG00000109270 E012 159.469129 0.0025025025 5.964379e-01 7.183852e-01 4 99881978 99882067 90 - 2.158 2.138 -0.066
ENSG00000109270 E013 125.879814 0.0002610747 4.559507e-01 5.964295e-01 4 99884062 99884125 64 - 2.056 2.033 -0.077
ENSG00000109270 E014 131.881968 0.0002801007 9.696745e-01 9.850261e-01 4 99885542 99885654 113 - 2.070 2.073 0.008
ENSG00000109270 E015 68.453630 0.0014135438 2.171205e-01 3.469226e-01 4 99885655 99885675 21 - 1.805 1.745 -0.203
ENSG00000109270 E016 98.215608 0.0003138224 6.040359e-01 7.246848e-01 4 99887296 99887354 59 - 1.948 1.930 -0.060
ENSG00000109270 E017 90.721389 0.0003266288 3.085493e-01 4.508406e-01 4 99892000 99892034 35 - 1.919 1.878 -0.136
ENSG00000109270 E018 79.548883 0.0042712544 7.235555e-01 8.173506e-01 4 99893955 99894000 46 - 1.857 1.834 -0.077
ENSG00000109270 E019 86.021548 0.0014407904 7.805535e-03 2.328974e-02 4 99894335 99894428 94 - 1.916 1.790 -0.423