ENSG00000109265

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000264229 ENSG00000109265 HEK293_OSMI2_2hA HEK293_TMG_2hB CRACD protein_coding protein_coding 2.021168 1.726246 2.474667 0.06345348 0.1699397 0.5170808 0.6359518 1.0535357 0.0000000 0.04538350 0.00000000 -6.732725 0.3456750 0.61293333 0.0000000 -0.61293333 7.776255e-21 7.776255e-21 FALSE TRUE
ENST00000541073 ENSG00000109265 HEK293_OSMI2_2hA HEK293_TMG_2hB CRACD protein_coding protein_coding 2.021168 1.726246 2.474667 0.06345348 0.1699397 0.5170808 0.1062477 0.1593023 0.0000000 0.15930228 0.00000000 -4.081529 0.0605250 0.09663333 0.0000000 -0.09663333 7.002992e-01 7.776255e-21 FALSE TRUE
ENST00000682029 ENSG00000109265 HEK293_OSMI2_2hA HEK293_TMG_2hB CRACD protein_coding protein_coding 2.021168 1.726246 2.474667 0.06345348 0.1699397 0.5170808 0.7712425 0.3688210 1.8031622 0.19015241 0.01921368 2.258920 0.3549333 0.20796667 0.7360000 0.52803333 9.477491e-02 7.776255e-21 FALSE TRUE
MSTRG.24916.3 ENSG00000109265 HEK293_OSMI2_2hA HEK293_TMG_2hB CRACD protein_coding   2.021168 1.726246 2.474667 0.06345348 0.1699397 0.5170808 0.4568374 0.1445872 0.6243389 0.04685918 0.15345411 2.036833 0.2114000 0.08250000 0.2458333 0.16333333 5.097702e-02 7.776255e-21 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000109265 E001 3.5406710 0.1470337377 0.0255156038 0.0629424542 4 56049098 56049218 121 + 0.817 0.334 -2.269
ENSG00000109265 E002 4.9016392 0.0321154477 0.0019322556 0.0070157354 4 56049219 56049299 81 + 0.930 0.463 -1.981
ENSG00000109265 E003 0.0000000       4 56049847 56050012 166 +      
ENSG00000109265 E004 0.0000000       4 56170195 56170250 56 +      
ENSG00000109265 E005 10.3328841 0.0129187771 0.0492639390 0.1078587000 4 56179284 56179430 147 + 1.131 0.953 -0.653
ENSG00000109265 E006 0.5879639 0.0198140749 0.4167899682 0.5601688411 4 56196344 56196427 84 + 0.264 0.140 -1.137
ENSG00000109265 E007 0.0000000       4 56216102 56216273 172 +      
ENSG00000109265 E008 0.0000000       4 56246503 56246712 210 +      
ENSG00000109265 E009 11.5789667 0.0015158361 0.1700053369 0.2881991276 4 56272321 56272403 83 + 1.140 1.052 -0.320
ENSG00000109265 E010 14.8408430 0.0014365429 0.2256575195 0.3571708825 4 56272404 56272492 89 + 1.227 1.167 -0.214
ENSG00000109265 E011 0.1817044 0.0392518194 0.4030991070   4 56297840 56297996 157 + 0.000 0.140 9.547
ENSG00000109265 E012 9.0327604 0.0370792297 0.4678827888 0.6073279867 4 56298214 56298349 136 + 1.020 0.973 -0.173
ENSG00000109265 E013 0.0000000       4 56301226 56301247 22 +      
ENSG00000109265 E014 21.0198201 0.0111126262 0.4044073156 0.5481141585 4 56307535 56307699 165 + 1.351 1.327 -0.084
ENSG00000109265 E015 0.0000000       4 56308929 56309109 181 +      
ENSG00000109265 E016 14.2715416 0.0390381754 0.4184670785 0.5617318721 4 56310666 56310734 69 + 1.205 1.157 -0.170
ENSG00000109265 E017 0.0000000       4 56310872 56311069 198 +      
ENSG00000109265 E018 0.1472490 0.0424953822 0.5871420063   4 56311208 56311621 414 + 0.107 0.000 -9.823
ENSG00000109265 E019 21.3782513 0.0008584988 0.0161562689 0.0430716371 4 56313197 56313379 183 + 1.407 1.276 -0.456
ENSG00000109265 E020 118.0227385 0.0003004109 0.0001893247 0.0009183008 4 56314040 56316323 2284 + 2.101 2.040 -0.204
ENSG00000109265 E021 31.9014781 0.0007138012 0.4339426394 0.5763391460 4 56316324 56316662 339 + 1.468 1.561 0.316
ENSG00000109265 E022 11.8923205 0.0029651701 0.4638729723 0.6036456886 4 56316663 56316689 27 + 1.042 1.156 0.411
ENSG00000109265 E023 23.5931601 0.0090435962 0.5451991870 0.6755952328 4 56323377 56323567 191 + 1.340 1.431 0.316
ENSG00000109265 E024 19.7191164 0.0010895456 0.8793484987 0.9264981983 4 56324104 56324266 163 + 1.300 1.333 0.117
ENSG00000109265 E025 15.2026989 0.0014806380 0.3832290525 0.5274099147 4 56327644 56327800 157 + 1.157 1.276 0.418
ENSG00000109265 E026 152.2497207 0.0168605447 0.0006437795 0.0026935687 4 56327801 56330609 2809 + 2.067 2.288 0.740
ENSG00000109265 E027 0.0000000       4 56330728 56330826 99 +