ENSG00000109184

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000334635 ENSG00000109184 HEK293_OSMI2_2hA HEK293_TMG_2hB DCUN1D4 protein_coding protein_coding 12.46932 3.02003 21.53279 0.2296331 1.40063 2.829801 6.89307858 0.5534998 12.67494573 0.29894134 0.51792771 4.492558 0.45287083 0.17980000 0.590600000 0.41080000 1.677153e-01 1.928121e-05 FALSE TRUE
ENST00000381441 ENSG00000109184 HEK293_OSMI2_2hA HEK293_TMG_2hB DCUN1D4 protein_coding protein_coding 12.46932 3.02003 21.53279 0.2296331 1.40063 2.829801 0.70583720 0.4843985 1.76385365 0.04847679 0.40040893 1.843141 0.05425000 0.16223333 0.080533333 -0.08170000 6.443122e-02 1.928121e-05 FALSE TRUE
ENST00000507659 ENSG00000109184 HEK293_OSMI2_2hA HEK293_TMG_2hB DCUN1D4 protein_coding processed_transcript 12.46932 3.02003 21.53279 0.2296331 1.40063 2.829801 0.05108152 0.2000885 0.06871277 0.20008854 0.06871277 -1.416328 0.01142917 0.06693333 0.003633333 -0.06330000 7.484644e-01 1.928121e-05   FALSE
ENST00000508257 ENSG00000109184 HEK293_OSMI2_2hA HEK293_TMG_2hB DCUN1D4 protein_coding processed_transcript 12.46932 3.02003 21.53279 0.2296331 1.40063 2.829801 0.17465672 0.5032792 0.04969736 0.50327922 0.04969736 -3.104005 0.04307500 0.14663333 0.002100000 -0.14453333 7.026585e-01 1.928121e-05 FALSE FALSE
ENST00000510808 ENSG00000109184 HEK293_OSMI2_2hA HEK293_TMG_2hB DCUN1D4 protein_coding protein_coding 12.46932 3.02003 21.53279 0.2296331 1.40063 2.829801 0.22867673 0.0000000 0.00000000 0.00000000 0.00000000 0.000000 0.05870417 0.00000000 0.000000000 0.00000000   1.928121e-05 FALSE FALSE
ENST00000512199 ENSG00000109184 HEK293_OSMI2_2hA HEK293_TMG_2hB DCUN1D4 protein_coding nonsense_mediated_decay 12.46932 3.02003 21.53279 0.2296331 1.40063 2.829801 0.07891027 0.3994387 0.07506732 0.20022204 0.07506732 -2.266971 0.02122917 0.14286667 0.003166667 -0.13970000 2.089818e-01 1.928121e-05   FALSE
ENST00000513800 ENSG00000109184 HEK293_OSMI2_2hA HEK293_TMG_2hB DCUN1D4 protein_coding processed_transcript 12.46932 3.02003 21.53279 0.2296331 1.40063 2.829801 0.61991932 0.1755301 1.31591173 0.10771287 0.24829420 2.837260 0.05125417 0.06340000 0.060300000 -0.00310000 9.142639e-01 1.928121e-05 FALSE FALSE
MSTRG.24868.9 ENSG00000109184 HEK293_OSMI2_2hA HEK293_TMG_2hB DCUN1D4 protein_coding   12.46932 3.02003 21.53279 0.2296331 1.40063 2.829801 0.72194824 0.0000000 1.49483304 0.00000000 0.16064545 7.233460 0.03353750 0.00000000 0.070566667 0.07056667 1.928121e-05 1.928121e-05 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000109184 E001 0.0000000       4 51843000 51843060 61 +      
ENSG00000109184 E002 0.0000000       4 51843061 51843062 2 +      
ENSG00000109184 E003 0.2924217 0.0277303132 1.000000e+00   4 51843063 51843102 40 + 0.094 0.000 -10.193
ENSG00000109184 E004 0.2924217 0.0277303132 1.000000e+00   4 51843103 51843130 28 + 0.094 0.000 -11.823
ENSG00000109184 E005 0.2924217 0.0277303132 1.000000e+00   4 51843131 51843132 2 + 0.094 0.000 -11.823
ENSG00000109184 E006 0.2924217 0.0277303132 1.000000e+00   4 51843133 51843135 3 + 0.094 0.000 -11.823
ENSG00000109184 E007 1.9723285 0.0358478738 5.725773e-01 6.986671e-01 4 51843136 51843152 17 + 0.388 0.274 -0.714
ENSG00000109184 E008 17.4993379 0.1047289538 2.474778e-01 3.829823e-01 4 51843153 51843196 44 + 1.143 0.954 -0.690
ENSG00000109184 E009 36.6586248 0.0239303659 7.658926e-03 2.292378e-02 4 51843197 51843267 71 + 1.456 1.153 -1.059
ENSG00000109184 E010 0.9535377 0.1031787989 7.859698e-01 8.629411e-01 4 51843541 51843578 38 + 0.204 0.276 0.563
ENSG00000109184 E011 1.6857439 0.0801423092 7.376875e-01 8.277863e-01 4 51843579 51843742 164 + 0.342 0.275 -0.438
ENSG00000109184 E012 0.7792333 0.0297620443 6.491135e-01 7.604750e-01 4 51844884 51845243 360 + 0.171 0.274 0.872
ENSG00000109184 E013 4.9292889 0.0224212115 5.540384e-01 6.830857e-01 4 51848205 51848367 163 + 0.652 0.562 -0.397
ENSG00000109184 E014 4.2762001 0.0084299187 3.259447e-01 4.693909e-01 4 51860543 51860663 121 + 0.616 0.441 -0.826
ENSG00000109184 E015 56.4690427 0.0013013211 7.021786e-04 2.906902e-03 4 51863437 51863507 71 + 1.631 1.409 -0.759
ENSG00000109184 E016 50.9533857 0.0007571852 1.712462e-03 6.321447e-03 4 51863670 51863709 40 + 1.587 1.378 -0.717
ENSG00000109184 E017 71.2540334 0.0003405206 2.610100e-04 1.220656e-03 4 51874271 51874385 115 + 1.729 1.526 -0.690
ENSG00000109184 E018 11.3280859 0.0792290617 6.558847e-01 7.656993e-01 4 51874721 51875328 608 + 0.933 1.032 0.365
ENSG00000109184 E019 6.3820600 0.0026549716 4.859086e-01 6.237307e-01 4 51877456 51877762 307 + 0.746 0.655 -0.375
ENSG00000109184 E020 67.6694995 0.0005814738 4.975401e-06 3.542981e-05 4 51877763 51877854 92 + 1.714 1.424 -0.991
ENSG00000109184 E021 0.1472490 0.0451373138 8.242258e-01   4 51877855 51877972 118 + 0.049 0.000 -10.707
ENSG00000109184 E022 0.2214452 0.0412992182 5.087988e-02   4 51884326 51884483 158 + 0.000 0.275 13.422
ENSG00000109184 E023 0.2966881 0.0268437283 1.000000e+00   4 51884911 51884959 49 + 0.094 0.000 -11.832
ENSG00000109184 E024 76.7871383 0.0012054372 1.245446e-04 6.346216e-04 4 51886568 51886638 71 + 1.763 1.548 -0.729
ENSG00000109184 E025 4.7156899 0.0036100737 1.199124e-03 4.637458e-03 4 51886639 51887122 484 + 0.517 1.029 2.083
ENSG00000109184 E026 3.0753027 0.0178822007 1.284706e-01 2.320296e-01 4 51887123 51887244 122 + 0.429 0.734 1.391
ENSG00000109184 E027 64.7676493 0.0011098740 4.838533e-03 1.548152e-02 4 51891760 51891806 47 + 1.683 1.526 -0.533
ENSG00000109184 E028 49.9942893 0.0007045450 1.434199e-02 3.900608e-02 4 51891807 51891851 45 + 1.573 1.424 -0.513
ENSG00000109184 E029 54.2892151 0.0004723432 1.288367e-03 4.937635e-03 4 51899270 51899336 67 + 1.615 1.409 -0.704
ENSG00000109184 E030 41.1989593 0.0032162680 3.253072e-01 4.687467e-01 4 51899337 51899378 42 + 1.480 1.438 -0.146
ENSG00000109184 E031 1.0361780 0.0336989749 2.899242e-03 9.967384e-03 4 51905189 51905320 132 + 0.094 0.656 3.873
ENSG00000109184 E032 1.1040209 0.0117981220 2.811812e-01 4.210683e-01 4 51908920 51908975 56 + 0.204 0.441 1.551
ENSG00000109184 E033 1.7789682 0.0090047806 6.278352e-01 7.435279e-01 4 51909158 51909208 51 + 0.319 0.441 0.704
ENSG00000109184 E034 1.2596890 0.0105928964 3.656939e-01 5.099901e-01 4 51909400 51909452 53 + 0.236 0.441 1.287
ENSG00000109184 E035 0.7406253 0.0153484531 6.036369e-01 7.243803e-01 4 51910753 51911069 317 + 0.204 0.000 -13.219
ENSG00000109184 E036 43.9655420 0.0006648587 3.974757e-02 9.055737e-02 4 51911070 51911174 105 + 1.520 1.394 -0.434
ENSG00000109184 E037 62.0740132 0.0013983464 4.071169e-01 5.507268e-01 4 51913290 51913392 103 + 1.651 1.636 -0.051
ENSG00000109184 E038 719.2508359 0.0012031437 1.951133e-25 2.228067e-23 4 51913529 51916837 3309 + 2.671 2.857 0.621