ENSG00000109180

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000264312 ENSG00000109180 HEK293_OSMI2_2hA HEK293_TMG_2hB OCIAD1 protein_coding protein_coding 93.73124 42.13153 144.8928 2.955948 2.420914 1.781771 23.918479 16.698083 31.465046 2.0909468 1.7159138 0.9136623 0.27958750 0.39393333 0.2173333 -0.176600000 1.071493e-05 1.071493e-05 FALSE TRUE
ENST00000381473 ENSG00000109180 HEK293_OSMI2_2hA HEK293_TMG_2hB OCIAD1 protein_coding protein_coding 93.73124 42.13153 144.8928 2.955948 2.420914 1.781771 5.356510 2.496564 9.338871 0.4626565 0.8208083 1.8990812 0.05962083 0.06140000 0.0646000 0.003200000 9.138157e-01 1.071493e-05 FALSE TRUE
ENST00000503016 ENSG00000109180 HEK293_OSMI2_2hA HEK293_TMG_2hB OCIAD1 protein_coding protein_coding 93.73124 42.13153 144.8928 2.955948 2.420914 1.781771 17.368127 7.204162 25.632444 1.4914586 1.5655463 1.8296300 0.17770833 0.16776667 0.1772333 0.009466667 9.199409e-01 1.071493e-05 FALSE FALSE
ENST00000509664 ENSG00000109180 HEK293_OSMI2_2hA HEK293_TMG_2hB OCIAD1 protein_coding protein_coding 93.73124 42.13153 144.8928 2.955948 2.420914 1.781771 8.694471 3.022605 18.310317 1.0434297 2.2615949 2.5948151 0.07943750 0.06953333 0.1262667 0.056733333 3.424296e-01 1.071493e-05   FALSE
ENST00000511102 ENSG00000109180 HEK293_OSMI2_2hA HEK293_TMG_2hB OCIAD1 protein_coding protein_coding 93.73124 42.13153 144.8928 2.955948 2.420914 1.781771 21.815398 6.076765 34.388748 0.4742000 2.3750298 2.4986085 0.22151667 0.14700000 0.2371000 0.090100000 5.150567e-02 1.071493e-05 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000109180 E001 0.0000000       4 48805212 48805330 119 +      
ENSG00000109180 E002 0.0000000       4 48830577 48830673 97 +      
ENSG00000109180 E003 0.2987644 0.0271750576 6.034938e-01   4 48830982 48830997 16 + 0.147 0.000 -10.041
ENSG00000109180 E004 0.8491631 0.0200362751 5.845511e-01 7.084403e-01 4 48830998 48831008 11 + 0.205 0.313 0.804
ENSG00000109180 E005 4.3384745 0.0656933280 2.463312e-01 3.816474e-01 4 48831009 48831043 35 + 0.625 0.833 0.850
ENSG00000109180 E006 6.1120450 0.0068844329 5.279025e-01 6.608444e-01 4 48831044 48831052 9 + 0.795 0.894 0.386
ENSG00000109180 E007 0.1817044 0.0430665290 1.888276e-01   4 48831053 48831058 6 + 0.000 0.184 11.806
ENSG00000109180 E008 1.1447053 0.0200912635 4.279565e-01 5.707796e-01 4 48831059 48831062 4 + 0.256 0.412 0.972
ENSG00000109180 E009 1.3264096 0.0349949502 2.156918e-01 3.452254e-01 4 48831063 48831064 2 + 0.257 0.492 1.388
ENSG00000109180 E010 1.3264096 0.0349949502 2.156918e-01 3.452254e-01 4 48831065 48831065 1 + 0.257 0.492 1.388
ENSG00000109180 E011 12.1346519 0.0038764807 2.968127e-01 4.380896e-01 4 48831066 48831081 16 + 1.044 1.167 0.444
ENSG00000109180 E012 13.8695242 0.0107243845 2.644107e-01 4.023778e-01 4 48831082 48831083 2 + 1.096 1.226 0.463
ENSG00000109180 E013 16.8148513 0.0235164706 1.037923e-01 1.962898e-01 4 48831084 48831087 4 + 1.149 1.336 0.661
ENSG00000109180 E014 68.7247736 0.0044549679 3.803743e-01 5.246698e-01 4 48831088 48831107 20 + 1.790 1.852 0.211
ENSG00000109180 E015 78.8039251 0.0014559986 6.382890e-01 7.519412e-01 4 48831108 48831117 10 + 1.858 1.897 0.133
ENSG00000109180 E016 102.4464335 0.0003098577 7.244928e-01 8.179948e-01 4 48831118 48831136 19 + 1.982 1.988 0.019
ENSG00000109180 E017 92.8100584 0.0006654609 1.930685e-01 3.176217e-01 4 48831137 48831141 5 + 1.952 1.917 -0.119
ENSG00000109180 E018 100.7266304 0.0061423432 3.037399e-01 4.457074e-01 4 48831142 48831152 11 + 1.989 1.946 -0.145
ENSG00000109180 E019 110.8018327 0.0040795638 1.037741e-01 1.962593e-01 4 48831153 48831171 19 + 2.037 1.973 -0.213
ENSG00000109180 E020 196.5131035 0.0024681535 3.270551e-01 4.704923e-01 4 48831172 48831222 51 + 2.272 2.253 -0.062
ENSG00000109180 E021 159.6159129 0.0010337228 5.395639e-01 6.708149e-01 4 48831223 48831226 4 + 2.177 2.175 -0.006
ENSG00000109180 E022 203.7839314 0.0004207844 8.200577e-02 1.626881e-01 4 48831227 48831249 23 + 2.291 2.261 -0.100
ENSG00000109180 E023 22.7011031 0.0044452264 1.653840e-01 2.821946e-01 4 48831250 48831253 4 + 1.376 1.276 -0.349
ENSG00000109180 E024 35.4382215 0.0060111147 1.919712e-01 3.162412e-01 4 48831254 48831305 52 + 1.554 1.476 -0.270
ENSG00000109180 E025 46.9723985 0.0004803345 3.166884e-03 1.075866e-02 4 48831306 48831341 36 + 1.693 1.540 -0.520
ENSG00000109180 E026 101.7597773 0.0003164332 3.372604e-11 6.438228e-10 4 48831342 48831398 57 + 2.047 1.789 -0.869
ENSG00000109180 E027 107.7332562 0.0003020887 1.414562e-09 2.039766e-08 4 48831399 48831433 35 + 2.065 1.841 -0.751
ENSG00000109180 E028 128.0403257 0.0002884372 2.243042e-09 3.115232e-08 4 48831434 48831496 63 + 2.133 1.933 -0.670
ENSG00000109180 E029 10.8771439 0.0015371246 9.973616e-01 1.000000e+00 4 48831497 48831531 35 + 1.044 1.062 0.064
ENSG00000109180 E030 425.3068618 0.0002155944 5.908389e-05 3.269443e-04 4 48832620 48832682 63 + 2.618 2.558 -0.197
ENSG00000109180 E031 5.7626595 0.0027271753 2.485221e-02 6.156768e-02 4 48832683 48832761 79 + 0.883 0.560 -1.336
ENSG00000109180 E032 452.9945381 0.0001187933 1.566106e-03 5.849533e-03 4 48833401 48833481 81 + 2.640 2.602 -0.126
ENSG00000109180 E033 0.4482035 0.0290101511 3.526410e-01 4.968923e-01 4 48837160 48837252 93 + 0.205 0.000 -12.685
ENSG00000109180 E034 337.5414762 0.0001436748 6.163204e-01 7.344046e-01 4 48842636 48842689 54 + 2.498 2.507 0.031
ENSG00000109180 E035 352.0994451 0.0001629315 3.717625e-01 5.162341e-01 4 48848399 48848446 48 + 2.517 2.518 0.003
ENSG00000109180 E036 1.4402475 0.0715626038 3.455811e-01 4.896951e-01 4 48848447 48848669 223 + 0.302 0.491 1.061
ENSG00000109180 E037 564.5888387 0.0001650301 3.925881e-01 5.365439e-01 4 48849947 48850082 136 + 2.712 2.745 0.109
ENSG00000109180 E038 4.5164846 0.0036419039 2.842329e-01 4.244540e-01 4 48850083 48850083 1 + 0.766 0.619 -0.615
ENSG00000109180 E039 664.1508404 0.0003476460 1.055694e-02 3.010719e-02 4 48851806 48851975 170 + 2.774 2.834 0.201
ENSG00000109180 E040 8.7502392 0.0070030842 1.028613e-01 1.948423e-01 4 48851976 48852020 45 + 1.020 0.831 -0.713
ENSG00000109180 E041 16.6426103 0.0393073268 1.000214e-03 3.958957e-03 4 48852021 48852191 171 + 1.318 0.862 -1.656
ENSG00000109180 E042 18.8434156 0.0010774737 7.076472e-08 7.394872e-07 4 48852192 48852504 313 + 1.379 0.832 -1.987
ENSG00000109180 E043 28.3359134 0.0252815895 5.223762e-01 6.562029e-01 4 48855972 48857212 1241 + 1.456 1.419 -0.127
ENSG00000109180 E044 695.6221965 0.0006036929 2.082278e-05 1.286422e-04 4 48857213 48857365 153 + 2.782 2.874 0.305
ENSG00000109180 E045 889.8765673 0.0032811495 1.005216e-05 6.675613e-05 4 48860725 48861817 1093 + 2.872 3.007 0.451