ENSG00000109118

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000332830 ENSG00000109118 HEK293_OSMI2_2hA HEK293_TMG_2hB PHF12 protein_coding protein_coding 12.37027 13.78574 11.55622 0.9988831 0.3524369 -0.2543055 4.5480241 6.4529599 3.733595 0.40645210 0.29002059 -0.7877705 0.35905417 0.4759333 0.3245333 -0.15140000 0.19880429 0.0003880374 FALSE  
ENST00000577226 ENSG00000109118 HEK293_OSMI2_2hA HEK293_TMG_2hB PHF12 protein_coding protein_coding 12.37027 13.78574 11.55622 0.9988831 0.3524369 -0.2543055 1.1540375 0.7929728 1.262561 0.05655524 0.05065219 0.6643123 0.09657917 0.0579000 0.1096333 0.05173333 0.01232946 0.0003880374 FALSE  
ENST00000589176 ENSG00000109118 HEK293_OSMI2_2hA HEK293_TMG_2hB PHF12 protein_coding nonsense_mediated_decay 12.37027 13.78574 11.55622 0.9988831 0.3524369 -0.2543055 0.6714142 2.4571054 0.000000 1.22855562 0.00000000 -7.9466755 0.04962917 0.1707000 0.0000000 -0.17070000 0.15930333 0.0003880374 FALSE  
MSTRG.13993.3 ENSG00000109118 HEK293_OSMI2_2hA HEK293_TMG_2hB PHF12 protein_coding   12.37027 13.78574 11.55622 0.9988831 0.3524369 -0.2543055 3.6169068 3.2993121 3.547737 0.44702550 0.14134396 0.1044283 0.29467083 0.2406667 0.3072667 0.06660000 0.41256176 0.0003880374 FALSE  
MSTRG.13993.4 ENSG00000109118 HEK293_OSMI2_2hA HEK293_TMG_2hB PHF12 protein_coding   12.37027 13.78574 11.55622 0.9988831 0.3524369 -0.2543055 1.1561113 0.0000000 1.299966 0.00000000 0.72745388 7.0333853 0.09815833 0.0000000 0.1110333 0.11103333 0.17084273 0.0003880374 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000109118 E001 0.6997360 0.0167407331 6.086419e-02 1.280919e-01 17 28905250 28905252 3 - 0.000 0.336 11.361
ENSG00000109118 E002 87.5399933 0.0102261089 3.366015e-06 2.492696e-05 17 28905253 28905633 381 - 1.735 2.038 1.022
ENSG00000109118 E003 156.4784928 0.0004566266 1.130974e-13 3.188387e-12 17 28905634 28906074 441 - 2.032 2.265 0.779
ENSG00000109118 E004 76.9231119 0.0010966655 1.690869e-03 6.253883e-03 17 28906075 28906104 30 - 1.790 1.932 0.478
ENSG00000109118 E005 77.2265080 0.0006605386 1.938592e-03 7.036180e-03 17 28906105 28906129 25 - 1.797 1.933 0.457
ENSG00000109118 E006 229.7511247 0.0036014378 3.038347e-04 1.394867e-03 17 28906130 28906517 388 - 2.265 2.403 0.461
ENSG00000109118 E007 15.8632290 0.0067475953 5.466065e-03 1.719835e-02 17 28906518 28906855 338 - 1.357 1.111 -0.869
ENSG00000109118 E008 128.0397895 0.0026895841 1.902678e-02 4.939252e-02 17 28906856 28906994 139 - 2.038 2.136 0.330
ENSG00000109118 E009 21.7719103 0.0010158033 1.261409e-01 2.287794e-01 17 28906995 28907589 595 - 1.403 1.294 -0.379
ENSG00000109118 E010 105.2803886 0.0003306946 2.753631e-01 4.146567e-01 17 28907590 28907672 83 - 1.989 2.032 0.143
ENSG00000109118 E011 46.2862191 0.0033295321 1.715196e-10 2.908249e-09 17 28907673 28908782 1110 - 1.840 1.473 -1.247
ENSG00000109118 E012 110.7287528 0.0005208558 9.877069e-04 3.916571e-03 17 28908783 28908881 99 - 1.961 2.082 0.406
ENSG00000109118 E013 10.7382557 0.0016560047 3.632207e-01 5.076509e-01 17 28908882 28909569 688 - 1.113 1.027 -0.314
ENSG00000109118 E014 14.5940782 0.0011980301 6.692314e-01 7.760821e-01 17 28909570 28910054 485 - 1.159 1.201 0.149
ENSG00000109118 E015 6.0581184 0.0026453795 2.434833e-01 3.782715e-01 17 28910055 28910073 19 - 0.917 0.775 -0.548
ENSG00000109118 E016 9.8610923 0.0030765702 5.453520e-01 6.757139e-01 17 28910074 28910225 152 - 1.062 1.002 -0.218
ENSG00000109118 E017 90.6987221 0.0003883160 1.060044e-02 3.020973e-02 17 28910226 28910269 44 - 1.888 1.990 0.343
ENSG00000109118 E018 113.2103781 0.0002730978 6.815150e-03 2.074272e-02 17 28910270 28910369 100 - 1.984 2.081 0.324
ENSG00000109118 E019 2.6842323 0.0265506053 2.599523e-03 9.062953e-03 17 28910712 28910833 122 - 0.784 0.274 -2.529
ENSG00000109118 E020 71.6136987 0.0003420062 2.553197e-01 3.921771e-01 17 28911112 28911132 21 - 1.817 1.869 0.177
ENSG00000109118 E021 96.7952581 0.0002940869 4.391509e-01 5.809194e-01 17 28911133 28911174 42 - 1.957 1.990 0.109
ENSG00000109118 E022 96.0308131 0.0005931313 7.245181e-01 8.180137e-01 17 28911175 28911237 63 - 1.961 1.978 0.059
ENSG00000109118 E023 3.0111068 0.0443673524 2.139606e-01 3.432018e-01 17 28911238 28911329 92 - 0.698 0.486 -0.949
ENSG00000109118 E024 2.9464730 0.0233422125 5.101496e-01 6.453930e-01 17 28911330 28911384 55 - 0.630 0.525 -0.473
ENSG00000109118 E025 0.4545463 0.6741662772 2.343059e-01 3.675299e-01 17 28912144 28912481 338 - 0.322 0.000 -11.871
ENSG00000109118 E026 146.6880048 0.0035726985 6.014306e-01 7.225611e-01 17 28912482 28912681 200 - 2.164 2.150 -0.047
ENSG00000109118 E027 199.4370495 0.0002770148 8.236962e-01 8.889287e-01 17 28912682 28913112 431 - 2.291 2.290 -0.004
ENSG00000109118 E028 72.9174719 0.0097700140 2.884402e-01 4.290357e-01 17 28913113 28913201 89 - 1.896 1.837 -0.197
ENSG00000109118 E029 55.4324706 0.0005822407 3.271792e-01 4.706206e-01 17 28913202 28913277 76 - 1.769 1.726 -0.143
ENSG00000109118 E030 89.8495343 0.0003167230 5.689927e-01 6.956064e-01 17 28913879 28914037 159 - 1.957 1.940 -0.057
ENSG00000109118 E031 56.6350173 0.0004381962 5.748177e-01 7.005622e-01 17 28917285 28917317 33 - 1.760 1.738 -0.075
ENSG00000109118 E032 94.3634711 0.0002936705 3.930030e-01 5.368979e-01 17 28917318 28917449 132 - 1.984 1.957 -0.090
ENSG00000109118 E033 96.3481874 0.0003429829 8.331423e-02 1.647578e-01 17 28919143 28919275 133 - 2.013 1.954 -0.196
ENSG00000109118 E034 98.7655502 0.0003361956 3.217577e-05 1.899652e-04 17 28921688 28921794 107 - 2.070 1.927 -0.480
ENSG00000109118 E035 56.2119616 0.0004223995 9.866386e-07 8.195542e-06 17 28921795 28921808 14 - 1.867 1.643 -0.758
ENSG00000109118 E036 104.2002072 0.0002870510 4.917890e-07 4.354660e-06 17 28923909 28924048 140 - 2.105 1.936 -0.567
ENSG00000109118 E037 48.1503862 0.0004933384 2.658853e-03 9.249350e-03 17 28924049 28924077 29 - 1.760 1.613 -0.501
ENSG00000109118 E038 106.7625671 0.0035487683 2.709039e-02 6.617575e-02 17 28924078 28924263 186 - 2.074 1.983 -0.304
ENSG00000109118 E039 62.4020622 0.0060966607 2.986353e-01 4.400940e-01 17 28924264 28924302 39 - 1.824 1.769 -0.185
ENSG00000109118 E040 5.6873239 0.0028605677 1.232373e-02 3.431103e-02 17 28924303 28925980 1678 - 0.971 0.654 -1.252
ENSG00000109118 E041 3.0873964 0.0052611324 1.294258e-03 4.956905e-03 17 28925981 28926781 801 - 0.833 0.336 -2.313
ENSG00000109118 E042 3.2055112 0.0048074427 6.746021e-02 1.391292e-01 17 28926782 28926873 92 - 0.757 0.483 -1.206
ENSG00000109118 E043 0.3666179 0.0292168793 8.704670e-01 9.206838e-01 17 28926874 28926990 117 - 0.134 0.111 -0.311
ENSG00000109118 E044 50.6135063 0.0104225986 4.972514e-01 6.338031e-01 17 28926991 28927013 23 - 1.726 1.683 -0.146
ENSG00000109118 E045 58.0743747 0.0173476576 2.548750e-01 3.916592e-01 17 28927014 28927063 50 - 1.809 1.723 -0.288
ENSG00000109118 E046 0.3697384 0.0274424043 2.677287e-01 4.060685e-01 17 28928198 28928290 93 - 0.000 0.200 10.370
ENSG00000109118 E047 3.4931018 0.0335154873 1.550199e-02 4.163497e-02 17 28944503 28944569 67 - 0.833 0.440 -1.729
ENSG00000109118 E048 0.5159433 0.2503283384 5.222502e-01 6.560842e-01 17 28949668 28950064 397 - 0.237 0.113 -1.288
ENSG00000109118 E049 82.3515794 0.0006348588 5.840380e-04 2.474953e-03 17 28950065 28950246 182 - 1.983 1.850 -0.445
ENSG00000109118 E050 0.6298062 0.0190230665 4.314660e-01 5.740245e-01 17 28950247 28950421 175 - 0.134 0.273 1.268
ENSG00000109118 E051 1.7465125 0.0222307157 5.116330e-01 6.466004e-01 17 28950422 28950894 473 - 0.502 0.390 -0.581
ENSG00000109118 E052 48.7513878 0.0006027939 1.556325e-03 5.817931e-03 17 28950895 28951466 572 - 1.769 1.613 -0.528
ENSG00000109118 E053 8.5820509 0.0817161358 7.843758e-02 1.569804e-01 17 28951467 28951771 305 - 1.101 0.831 -1.009