ENSG00000109103

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000335765 ENSG00000109103 HEK293_OSMI2_2hA HEK293_TMG_2hB UNC119 protein_coding protein_coding 34.46408 55.97257 19.34603 2.276807 0.9537719 -1.532195 21.512000 38.620740 10.510172 2.0429347 0.6031977 -1.87659108 0.59950000 0.69113333 0.54560000 -0.145533333 0.119677194 0.002005295 FALSE  
ENST00000470125 ENSG00000109103 HEK293_OSMI2_2hA HEK293_TMG_2hB UNC119 protein_coding protein_coding 34.46408 55.97257 19.34603 2.276807 0.9537719 -1.532195 2.958385 2.071806 3.226134 1.0715741 0.1112913 0.63643602 0.10598333 0.03796667 0.16706667 0.129100000 0.342789171 0.002005295 FALSE  
ENST00000487844 ENSG00000109103 HEK293_OSMI2_2hA HEK293_TMG_2hB UNC119 protein_coding retained_intron 34.46408 55.97257 19.34603 2.276807 0.9537719 -1.532195 3.913324 5.194409 1.937185 0.9406433 0.7579953 -1.41834442 0.11418750 0.09216667 0.09723333 0.005066667 0.969683696 0.002005295 FALSE  
ENST00000578434 ENSG00000109103 HEK293_OSMI2_2hA HEK293_TMG_2hB UNC119 protein_coding retained_intron 34.46408 55.97257 19.34603 2.276807 0.9537719 -1.532195 1.979084 1.650120 1.742001 0.3216524 0.2769910 0.07771601 0.06953333 0.02920000 0.09040000 0.061200000 0.002005295 0.002005295 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000109103 E001 5.082411 0.0676102123 2.954923e-01 4.366183e-01 17 28546708 28546710 3 - 0.522 0.726 0.891
ENSG00000109103 E002 248.847245 0.0002259221 3.698189e-09 4.931795e-08 17 28546711 28546931 221 - 2.181 2.332 0.506
ENSG00000109103 E003 398.854220 0.0012329138 3.463607e-05 2.027594e-04 17 28546932 28547095 164 - 2.435 2.528 0.307
ENSG00000109103 E004 594.822206 0.0014009709 4.634629e-04 2.020008e-03 17 28547096 28547409 314 - 2.632 2.695 0.211
ENSG00000109103 E005 50.114605 0.0054958525 2.534861e-02 6.259001e-02 17 28547410 28547523 114 - 1.741 1.584 -0.533
ENSG00000109103 E006 41.764888 0.0007443482 8.738407e-02 1.711730e-01 17 28547524 28547641 118 - 1.632 1.512 -0.410
ENSG00000109103 E007 26.458866 0.0189845148 5.264302e-02 1.138607e-01 17 28547642 28547676 35 - 1.503 1.299 -0.705
ENSG00000109103 E008 156.150258 0.0010134012 2.217084e-02 5.602933e-02 17 28547677 28547687 11 - 2.047 2.117 0.233
ENSG00000109103 E009 354.453295 0.0002954883 2.453049e-02 6.091125e-02 17 28547688 28547849 162 - 2.427 2.463 0.119
ENSG00000109103 E010 131.759023 0.0003486140 2.117813e-01 3.405828e-01 17 28547999 28548009 11 - 2.002 2.033 0.104
ENSG00000109103 E011 221.122301 0.0033287094 1.941978e-01 3.190353e-01 17 28548010 28548101 92 - 2.222 2.258 0.122
ENSG00000109103 E012 16.350781 0.0081336188 9.409419e-01 9.668579e-01 17 28548102 28548173 72 - 1.158 1.135 -0.079
ENSG00000109103 E013 190.606505 0.0003741808 7.547385e-01 8.402853e-01 17 28548592 28548656 65 - 2.191 2.184 -0.020
ENSG00000109103 E014 138.047169 0.0002559152 1.852980e-01 3.078744e-01 17 28548657 28548705 49 - 2.024 2.056 0.108
ENSG00000109103 E015 281.458501 0.0033338961 2.159310e-37 6.293460e-35 17 28548706 28551802 3097 - 2.657 2.226 -1.435
ENSG00000109103 E016 24.974217 0.0008422758 4.682137e-17 2.094985e-15 17 28551825 28552064 240 - 1.713 1.115 -2.073
ENSG00000109103 E017 6.837889 0.0089255275 5.008808e-04 2.163335e-03 17 28552065 28552092 28 - 1.121 0.668 -1.741
ENSG00000109103 E018 175.267354 0.0130675177 2.260266e-01 3.576353e-01 17 28552338 28552631 294 - 2.105 2.165 0.200