ENSG00000109066

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000335464 ENSG00000109066 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM104 protein_coding protein_coding 21.25334 34.1558 11.67806 0.6777286 0.495534 -1.547517 14.0679449 21.006040 8.860630 1.8124287 0.2653132 -1.24438233 0.68185833 0.61440000 0.7608333 0.14643333 1.327013e-01 1.498766e-09 FALSE TRUE
ENST00000578764 ENSG00000109066 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM104 protein_coding protein_coding 21.25334 34.1558 11.67806 0.6777286 0.495534 -1.547517 1.1886375 1.148743 1.100838 0.5055082 0.3000112 -0.06091198 0.06062083 0.03400000 0.0932000 0.05920000 1.560121e-01 1.498766e-09 FALSE FALSE
ENST00000582773 ENSG00000109066 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM104 protein_coding protein_coding 21.25334 34.1558 11.67806 0.6777286 0.495534 -1.547517 1.6409612 1.828820 1.003639 0.2678267 0.2852324 -0.85923632 0.08631250 0.05356667 0.0842000 0.03063333 5.056406e-01 1.498766e-09 FALSE TRUE
ENST00000584171 ENSG00000109066 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM104 protein_coding processed_transcript 21.25334 34.1558 11.67806 0.6777286 0.495534 -1.547517 0.5529449 2.577016 0.000000 0.5740878 0.0000000 -8.01514491 0.01718750 0.07523333 0.0000000 -0.07523333 1.498766e-09 1.498766e-09 FALSE TRUE
MSTRG.15040.11 ENSG00000109066 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM104 protein_coding   21.25334 34.1558 11.67806 0.6777286 0.495534 -1.547517 2.0629214 5.690753 0.000000 2.1241117 0.0000000 -9.15500857 0.06499583 0.16730000 0.0000000 -0.16730000 5.665969e-08 1.498766e-09 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000109066 E001 1.133176 0.0759318230 5.767763e-01 7.021542e-01 17 74776486 74776496 11 + 0.181 0.309 1.008
ENSG00000109066 E002 1.133176 0.0759318230 5.767763e-01 7.021542e-01 17 74776497 74776498 2 + 0.181 0.309 1.008
ENSG00000109066 E003 1.133176 0.0759318230 5.767763e-01 7.021542e-01 17 74776499 74776499 1 + 0.181 0.309 1.008
ENSG00000109066 E004 2.530560 0.0078966782 6.364610e-01 7.504831e-01 17 74776500 74776508 9 + 0.406 0.513 0.545
ENSG00000109066 E005 12.695166 0.0123550272 8.061719e-01 8.767982e-01 17 74776509 74776519 11 + 1.074 1.075 0.006
ENSG00000109066 E006 45.481740 0.0181557507 9.013328e-01 9.411089e-01 17 74776520 74776577 58 + 1.564 1.612 0.166
ENSG00000109066 E007 42.286817 0.0140544663 8.748682e-01 9.235909e-01 17 74777264 74777266 3 + 1.532 1.581 0.169
ENSG00000109066 E008 86.283907 0.0084294671 3.472454e-02 8.112141e-02 17 74777267 74777375 109 + 1.938 1.849 -0.301
ENSG00000109066 E009 2.832457 0.0055233759 1.631868e-01 2.793111e-01 17 74777578 74777738 161 + 0.308 0.588 1.475
ENSG00000109066 E010 101.409037 0.0137965239 1.319719e-02 3.636873e-02 17 74785482 74785603 122 + 2.033 1.908 -0.420
ENSG00000109066 E011 1.216723 0.0108733282 4.263178e-01 5.691756e-01 17 74785604 74785680 77 + 0.181 0.348 1.252
ENSG00000109066 E012 18.839950 0.0010070441 9.583844e-02 1.841448e-01 17 74788747 74788788 42 + 1.314 1.203 -0.390
ENSG00000109066 E013 100.364204 0.0106779042 3.235569e-03 1.096035e-02 17 74788789 74788870 82 + 2.039 1.897 -0.476
ENSG00000109066 E014 138.332044 0.0008770673 5.139058e-06 3.647593e-05 17 74790200 74790296 97 + 2.165 2.039 -0.420
ENSG00000109066 E015 108.863053 0.0003697225 2.502742e-03 8.771217e-03 17 74790956 74791036 81 + 2.033 1.952 -0.273
ENSG00000109066 E016 129.514044 0.0011799731 6.776264e-02 1.396511e-01 17 74795012 74795111 100 + 2.075 2.039 -0.120
ENSG00000109066 E017 74.250712 0.0018489372 1.497767e-02 4.043773e-02 17 74795524 74795526 3 + 1.871 1.786 -0.288
ENSG00000109066 E018 143.356750 0.0003801508 2.667083e-03 9.273749e-03 17 74795527 74795632 106 + 2.143 2.076 -0.225
ENSG00000109066 E019 1.718975 0.0331315394 6.278625e-01 7.435375e-01 17 74798262 74798325 64 + 0.308 0.422 0.669
ENSG00000109066 E020 140.066627 0.0003154812 5.702924e-05 3.167034e-04 17 74819750 74819843 94 + 2.154 2.053 -0.336
ENSG00000109066 E021 298.488305 0.0004300817 7.356379e-04 3.027686e-03 17 74835927 74836497 571 + 2.442 2.395 -0.158
ENSG00000109066 E022 336.830294 0.0024627424 6.714581e-01 7.776742e-01 17 74836498 74837098 601 + 2.446 2.467 0.072
ENSG00000109066 E023 200.170585 0.0002248006 1.548412e-01 2.682008e-01 17 74837099 74837353 255 + 2.177 2.250 0.246
ENSG00000109066 E024 200.010001 0.0002247295 8.437105e-02 1.664047e-01 17 74837354 74837589 236 + 2.169 2.252 0.276
ENSG00000109066 E025 798.660984 0.0029479507 1.687548e-03 6.243304e-03 17 74837590 74838886 1297 + 2.748 2.863 0.383
ENSG00000109066 E026 573.496094 0.0069716395 3.028464e-06 2.263606e-05 17 74838887 74839795 909 + 2.519 2.740 0.738
ENSG00000109066 E027 2.106778 0.0069001980 2.313161e-07 2.191216e-06 17 74849273 74849344 72 + 0.887 0.081 -5.033