ENSG00000109065

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000357814 ENSG00000109065 HEK293_OSMI2_2hA HEK293_TMG_2hB NAT9 protein_coding protein_coding 61.61933 77.44086 43.96366 4.248965 2.913059 -0.8166414 18.153604 26.012935 10.457975 1.7131401 0.4515319 -1.3138014 0.28835000 0.33673333 0.2402000 -0.09653333 0.0708324733 3.013724e-06 FALSE TRUE
ENST00000580301 ENSG00000109065 HEK293_OSMI2_2hA HEK293_TMG_2hB NAT9 protein_coding protein_coding 61.61933 77.44086 43.96366 4.248965 2.913059 -0.8166414 15.858930 27.365656 9.381446 2.2176950 0.4104387 -1.5434743 0.24652500 0.35326667 0.2143333 -0.13893333 0.0001692167 3.013724e-06 FALSE TRUE
ENST00000581762 ENSG00000109065 HEK293_OSMI2_2hA HEK293_TMG_2hB NAT9 protein_coding retained_intron 61.61933 77.44086 43.96366 4.248965 2.913059 -0.8166414 5.600947 3.774676 5.893010 1.2111904 0.5940991 0.6412808 0.09578333 0.04736667 0.1341000 0.08673333 0.0037898562 3.013724e-06   FALSE
ENST00000583834 ENSG00000109065 HEK293_OSMI2_2hA HEK293_TMG_2hB NAT9 protein_coding retained_intron 61.61933 77.44086 43.96366 4.248965 2.913059 -0.8166414 4.018400 2.827719 3.245121 0.1059951 0.5499126 0.1979796 0.06676250 0.03676667 0.0741000 0.03733333 0.0352135837 3.013724e-06 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000109065 E001 26.6313373 0.0143157190 3.402337e-02 7.980460e-02 17 74770529 74770566 38 - 1.226 1.446 0.767
ENSG00000109065 E002 53.3176981 0.0005583312 2.198185e-02 5.563655e-02 17 74770567 74770580 14 - 1.584 1.725 0.478
ENSG00000109065 E003 1133.4951691 0.0027672820 8.547778e-07 7.204160e-06 17 74770581 74771388 808 - 2.898 3.041 0.475
ENSG00000109065 E004 497.5536770 0.0036165876 8.985685e-03 2.624431e-02 17 74771389 74771557 169 - 2.572 2.675 0.343
ENSG00000109065 E005 296.5110878 0.0030252827 3.068284e-01 4.490118e-01 17 74771558 74771624 67 - 2.387 2.438 0.170
ENSG00000109065 E006 221.9220230 0.0005870278 8.943697e-01 9.364915e-01 17 74771625 74771659 35 - 2.291 2.302 0.037
ENSG00000109065 E007 221.4160984 0.0002408409 9.906417e-02 1.890409e-01 17 74771660 74771690 31 - 2.253 2.312 0.197
ENSG00000109065 E008 161.6817849 0.0002412048 5.454877e-02 1.171986e-01 17 74771691 74771694 4 - 2.106 2.181 0.251
ENSG00000109065 E009 191.0369346 0.0002125165 3.933016e-03 1.295395e-02 17 74771695 74771727 33 - 2.159 2.258 0.331
ENSG00000109065 E010 271.8807564 0.0002489954 1.402470e-01 2.483538e-01 17 74771728 74771763 36 - 2.347 2.398 0.169
ENSG00000109065 E011 212.0016822 0.0003226793 9.488254e-01 9.719273e-01 17 74771764 74771767 4 - 2.267 2.284 0.055
ENSG00000109065 E012 245.3802491 0.0012167751 9.235234e-01 9.558184e-01 17 74771768 74771793 26 - 2.329 2.347 0.061
ENSG00000109065 E013 273.1953798 0.0002174239 6.791128e-01 7.834075e-01 17 74771794 74771834 41 - 2.386 2.390 0.015
ENSG00000109065 E014 222.2242302 0.0001922906 1.612343e-01 2.767015e-01 17 74771835 74771858 24 - 2.316 2.294 -0.074
ENSG00000109065 E015 205.9452651 0.0002311572 6.486452e-02 1.348121e-01 17 74771960 74771977 18 - 2.294 2.258 -0.118
ENSG00000109065 E016 273.3385128 0.0002203165 9.889557e-03 2.849154e-02 17 74771978 74772030 53 - 2.424 2.377 -0.154
ENSG00000109065 E017 173.6024535 0.0019088559 2.886481e-03 9.930179e-03 17 74772031 74772039 9 - 2.257 2.167 -0.302
ENSG00000109065 E018 158.8079238 0.0002394086 4.309650e-03 1.401174e-02 17 74772040 74772051 12 - 2.205 2.132 -0.243
ENSG00000109065 E019 134.7361850 0.0003222891 3.331370e-03 1.123886e-02 17 74772052 74772054 3 - 2.140 2.057 -0.278
ENSG00000109065 E020 51.1659229 0.0013920649 2.117818e-17 9.905724e-16 17 74772055 74772117 63 - 1.924 1.499 -1.441
ENSG00000109065 E021 40.7930590 0.0166562518 7.166012e-10 1.093147e-08 17 74772118 74772174 57 - 1.860 1.370 -1.673
ENSG00000109065 E022 36.9537729 0.0027644164 1.035372e-12 2.535852e-11 17 74772175 74772217 43 - 1.788 1.360 -1.463
ENSG00000109065 E023 181.9150834 0.0002507516 1.927858e-01 3.172659e-01 17 74772218 74772237 20 - 2.227 2.204 -0.079
ENSG00000109065 E024 194.5885631 0.0002257980 5.254828e-01 6.588483e-01 17 74772238 74772265 28 - 2.243 2.239 -0.012
ENSG00000109065 E025 154.2931623 0.0003406416 7.958461e-01 8.696367e-01 17 74772266 74772271 6 - 2.122 2.144 0.075
ENSG00000109065 E026 153.6106406 0.0002331448 6.720375e-01 7.781312e-01 17 74772272 74772274 3 - 2.117 2.145 0.093
ENSG00000109065 E027 152.5172052 0.0002298054 7.167553e-01 8.123184e-01 17 74772275 74772277 3 - 2.115 2.141 0.086
ENSG00000109065 E028 21.6096648 0.0179943111 7.250524e-06 4.973172e-05 17 74772278 74772294 17 - 1.556 1.144 -1.437
ENSG00000109065 E029 35.1882787 0.0007842811 7.337573e-10 1.116083e-08 17 74772295 74772395 101 - 1.730 1.376 -1.212
ENSG00000109065 E030 21.7196011 0.0012119696 2.812637e-09 3.839498e-08 17 74772396 74772441 46 - 1.568 1.140 -1.488
ENSG00000109065 E031 23.6703915 0.0088508635 7.961291e-07 6.753969e-06 17 74772442 74772482 41 - 1.590 1.193 -1.374
ENSG00000109065 E032 25.4979678 0.0007884032 7.659691e-06 5.225255e-05 17 74772483 74772576 94 - 1.568 1.271 -1.025
ENSG00000109065 E033 25.6937695 0.0007764496 3.227477e-08 3.611552e-07 17 74772673 74772776 104 - 1.605 1.239 -1.266
ENSG00000109065 E034 25.5507008 0.0007454033 1.254015e-08 1.518791e-07 17 74772777 74772895 119 - 1.611 1.234 -1.303
ENSG00000109065 E035 161.0475385 0.0002511650 6.480408e-01 7.596175e-01 17 74772896 74772902 7 - 2.137 2.166 0.095
ENSG00000109065 E036 290.0545320 0.0004257914 8.047530e-01 8.757679e-01 17 74772903 74772993 91 - 2.399 2.419 0.067
ENSG00000109065 E037 186.3193539 0.0015796627 4.930565e-01 6.301181e-01 17 74772994 74773039 46 - 2.195 2.232 0.123
ENSG00000109065 E038 26.6814181 0.0125456145 1.515739e-06 1.210847e-05 17 74773040 74773310 271 - 1.640 1.245 -1.364
ENSG00000109065 E039 8.2898172 0.0020509518 1.284700e-03 4.925876e-03 17 74773311 74773353 43 - 1.144 0.799 -1.288
ENSG00000109065 E040 23.6169301 0.0059620184 6.800032e-05 3.705050e-04 17 74773354 74773575 222 - 1.533 1.230 -1.050
ENSG00000109065 E041 167.4470499 0.0003603106 2.563110e-01 3.932629e-01 17 74773576 74773608 33 - 2.140 2.190 0.165
ENSG00000109065 E042 125.1331262 0.0002967264 5.842930e-01 7.082556e-01 17 74773609 74773613 5 - 2.027 2.061 0.112
ENSG00000109065 E043 255.4763137 0.0002170740 8.337817e-01 8.958973e-01 17 74773614 74773685 72 - 2.345 2.365 0.065
ENSG00000109065 E044 62.9520432 0.0003838250 9.833207e-01 9.936441e-01 17 74773686 74773688 3 - 1.746 1.758 0.044
ENSG00000109065 E045 4.0135814 0.0048180180 8.606512e-01 9.141295e-01 17 74773866 74773939 74 - 0.639 0.677 0.161
ENSG00000109065 E046 3.4223952 0.0054138732 1.058726e-01 1.994139e-01 17 74773940 74773992 53 - 0.387 0.677 1.384
ENSG00000109065 E047 2.1712165 0.0154201700 5.436634e-01 6.742467e-01 17 74773993 74774042 50 - 0.387 0.506 0.617
ENSG00000109065 E048 0.9608228 0.1191221357 8.921979e-01 9.351219e-01 17 74774043 74774055 13 - 0.292 0.273 -0.133
ENSG00000109065 E049 1.2532576 0.0438994171 2.886087e-01 4.292156e-01 17 74774056 74774099 44 - 0.465 0.274 -1.124
ENSG00000109065 E050 2.0377883 0.0076625475 8.991661e-02 1.750083e-01 17 74775360 74775598 239 - 0.639 0.366 -1.342
ENSG00000109065 E051 3.1980305 0.0050096713 4.183235e-01 5.616036e-01 17 74775599 74775621 23 - 0.465 0.612 0.691
ENSG00000109065 E052 234.4432257 0.0002127777 4.783358e-01 6.167598e-01 17 74775622 74775707 86 - 2.299 2.332 0.109
ENSG00000109065 E053 12.2208149 0.0047141123 8.556925e-01 9.107775e-01 17 74775708 74775852 145 - 1.080 1.073 -0.026
ENSG00000109065 E054 5.3577206 0.0092979847 5.451755e-01 6.755835e-01 17 74775853 74776035 183 - 0.684 0.784 0.408
ENSG00000109065 E055 6.1108147 0.0027341683 4.460521e-01 5.875911e-01 17 74776036 74776266 231 - 0.725 0.843 0.467
ENSG00000109065 E056 155.6318826 0.0003605565 6.117215e-01 7.308000e-01 17 74776267 74776270 4 - 2.122 2.152 0.102
ENSG00000109065 E057 165.0955410 0.0002548108 6.215687e-01 7.385170e-01 17 74776271 74776308 38 - 2.148 2.177 0.098
ENSG00000109065 E058 94.7754331 0.0007336213 7.274330e-01 8.201561e-01 17 74776309 74776367 59 - 1.909 1.937 0.095