ENSG00000109046

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262394 ENSG00000109046 HEK293_OSMI2_2hA HEK293_TMG_2hB WSB1 protein_coding protein_coding 26.77833 9.46686 42.14919 1.661467 2.078797 2.153366 5.766834 4.4582781 7.064527 0.6026132 0.08723094 0.6629147 0.27810833 0.49740000 0.1682667 -0.3291333 1.812564e-03 7.045599e-12 FALSE TRUE
ENST00000583096 ENSG00000109046 HEK293_OSMI2_2hA HEK293_TMG_2hB WSB1 protein_coding retained_intron 26.77833 9.46686 42.14919 1.661467 2.078797 2.153366 10.232521 3.0290839 16.097342 0.9681661 0.24745005 2.4060100 0.37488750 0.30163333 0.3834333 0.0818000 5.992152e-01 7.045599e-12 FALSE FALSE
ENST00000583742 ENSG00000109046 HEK293_OSMI2_2hA HEK293_TMG_2hB WSB1 protein_coding protein_coding 26.77833 9.46686 42.14919 1.661467 2.078797 2.153366 1.181149 0.0000000 2.816962 0.0000000 0.35316346 8.1431085 0.02595417 0.00000000 0.0670000 0.0670000 7.045599e-12 7.045599e-12 FALSE FALSE
ENST00000584354 ENSG00000109046 HEK293_OSMI2_2hA HEK293_TMG_2hB WSB1 protein_coding retained_intron 26.77833 9.46686 42.14919 1.661467 2.078797 2.153366 6.034651 0.9018603 9.999678 0.6158803 1.71523382 3.4564389 0.17972917 0.08323333 0.2344000 0.1511667 3.046167e-01 7.045599e-12   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000109046 E001 0.5953508 0.0193874923 4.194411e-01 5.626973e-01 17 27294076 27294079 4 + 0.147 0.311 1.377
ENSG00000109046 E002 0.5953508 0.0193874923 4.194411e-01 5.626973e-01 17 27294080 27294086 7 + 0.147 0.311 1.377
ENSG00000109046 E003 0.8877725 0.0133456910 8.760308e-01 9.243877e-01 17 27294087 27294092 6 + 0.257 0.311 0.378
ENSG00000109046 E004 2.9892642 0.0054612712 9.760991e-01 9.890729e-01 17 27294093 27294102 10 + 0.582 0.618 0.156
ENSG00000109046 E005 3.8373951 0.0040595939 5.446767e-01 6.751024e-01 17 27294103 27294111 9 + 0.626 0.757 0.549
ENSG00000109046 E006 3.8373951 0.0040595939 5.446767e-01 6.751024e-01 17 27294112 27294113 2 + 0.626 0.757 0.549
ENSG00000109046 E007 11.3981247 0.0257309931 1.740701e-01 2.934711e-01 17 27294114 27294121 8 + 1.110 0.971 -0.508
ENSG00000109046 E008 21.7556397 0.0008757537 4.938240e-02 1.080619e-01 17 27294122 27294130 9 + 1.361 1.250 -0.388
ENSG00000109046 E009 55.3968066 0.0041156849 2.858033e-01 4.261641e-01 17 27294131 27294188 58 + 1.728 1.711 -0.058
ENSG00000109046 E010 111.6022178 0.0028985941 2.691030e-02 6.580284e-02 17 27294189 27294345 157 + 2.039 1.990 -0.165
ENSG00000109046 E011 97.1844824 0.0041621082 2.251650e-02 5.675471e-02 17 27294346 27294435 90 + 1.985 1.917 -0.227
ENSG00000109046 E012 0.9578041 0.0130149581 4.587792e-01 5.990624e-01 17 27297187 27297308 122 + 0.303 0.183 -0.940
ENSG00000109046 E013 4.3200315 0.0037006054 1.122395e-01 2.088110e-01 17 27301767 27301787 21 + 0.766 0.559 -0.884
ENSG00000109046 E014 59.8281300 0.0017268075 7.335704e-03 2.209107e-02 17 27301788 27301791 4 + 1.783 1.688 -0.321
ENSG00000109046 E015 69.6406442 0.0006230070 1.787129e-03 6.557928e-03 17 27301792 27301817 26 + 1.847 1.749 -0.331
ENSG00000109046 E016 85.6668576 0.0009260570 1.002826e-02 2.883258e-02 17 27301818 27301880 63 + 1.926 1.863 -0.211
ENSG00000109046 E017 98.9867732 0.0003136835 6.955667e-03 2.110868e-02 17 27301881 27301956 76 + 1.988 1.935 -0.178
ENSG00000109046 E018 1.4132927 0.0141796255 3.836189e-01 5.278155e-01 17 27301957 27302009 53 + 0.303 0.491 1.056
ENSG00000109046 E019 10.0565275 0.0240505365 3.441814e-03 1.155794e-02 17 27302435 27303319 885 + 1.104 0.717 -1.476
ENSG00000109046 E020 2.5798471 0.0134402547 1.481695e-02 4.007976e-02 17 27303320 27303366 47 + 0.626 0.183 -2.618
ENSG00000109046 E021 210.5441881 0.0017742538 5.498228e-05 3.065941e-04 17 27303367 27303635 269 + 2.321 2.239 -0.274
ENSG00000109046 E022 0.4396707 0.0269363913 3.240152e-01 4.673677e-01 17 27303636 27303749 114 + 0.205 0.001 -8.320
ENSG00000109046 E023 136.0700214 0.0013673315 5.652507e-02 1.206402e-01 17 27304780 27304911 132 + 2.117 2.099 -0.061
ENSG00000109046 E024 127.8527289 0.0008600971 8.159206e-01 8.834803e-01 17 27306782 27306882 101 + 2.072 2.115 0.145
ENSG00000109046 E025 43.7496231 0.0006888159 1.195209e-16 5.088289e-15 17 27306883 27307743 861 + 1.729 1.196 -1.840
ENSG00000109046 E026 69.6189610 0.0009787331 4.285791e-11 8.044489e-10 17 27307744 27309099 1356 + 1.891 1.600 -0.984
ENSG00000109046 E027 164.5217942 0.0002199932 7.949913e-01 8.690385e-01 17 27309100 27309272 173 + 2.179 2.222 0.146
ENSG00000109046 E028 128.3429737 0.0002522691 7.158059e-01 8.116288e-01 17 27310061 27310174 114 + 2.064 2.126 0.210
ENSG00000109046 E029 118.7956661 0.0003163505 1.429162e-02 3.889032e-02 17 27311509 27311616 108 + 2.006 2.140 0.447
ENSG00000109046 E030 574.9478028 0.0042508848 4.245010e-16 1.681732e-14 17 27312210 27315926 3717 + 2.628 2.895 0.888