ENSG00000108861

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000226004 ENSG00000108861 HEK293_OSMI2_2hA HEK293_TMG_2hB DUSP3 protein_coding protein_coding 33.35026 38.14015 31.49938 1.753529 1.198049 -0.2759076 26.663502 32.315312 23.396503 1.428824 0.2266064 -0.4657549 0.7997583 0.84770000 0.7447333 -0.1029667 0.03972075 0.03972075 FALSE TRUE
MSTRG.14411.1 ENSG00000108861 HEK293_OSMI2_2hA HEK293_TMG_2hB DUSP3 protein_coding   33.35026 38.14015 31.49938 1.753529 1.198049 -0.2759076 4.393063 2.731279 6.001809 1.060550 0.9315455 1.1329501 0.1324292 0.07116667 0.1893000 0.1181333 0.09895840 0.03972075 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000108861 E001 0.000000       17 43763520 43763565 46 -      
ENSG00000108861 E002 5.149992 0.0032332450 0.077744501 0.15584190 17 43766125 43766130 6 - 0.585 0.844 1.071
ENSG00000108861 E003 364.189011 0.0045413736 0.003121730 0.01062412 17 43766131 43766456 326 - 2.464 2.580 0.387
ENSG00000108861 E004 179.728068 0.0087798434 0.021672964 0.05499656 17 43766457 43766511 55 - 2.147 2.280 0.444
ENSG00000108861 E005 248.280913 0.0043745395 0.114171834 0.21162456 17 43766512 43766634 123 - 2.331 2.401 0.234
ENSG00000108861 E006 351.694650 0.0053986620 0.430099168 0.57274099 17 43766635 43766784 150 - 2.502 2.541 0.129
ENSG00000108861 E007 1254.336817 0.0005195947 0.232026419 0.36484955 17 43766785 43768385 1601 - 3.086 3.076 -0.033
ENSG00000108861 E008 1122.956843 0.0013982658 0.957155653 0.97716172 17 43768386 43769581 1196 - 3.028 3.030 0.008
ENSG00000108861 E009 420.857037 0.0034241446 0.394038160 0.53793577 17 43769582 43769814 233 - 2.620 2.594 -0.088
ENSG00000108861 E010 5.600264 0.1144421050 0.319012106 0.46204806 17 43773974 43774034 61 - 0.919 0.742 -0.692
ENSG00000108861 E011 9.096012 0.0206124810 0.942748311 0.96804197 17 43774035 43774109 75 - 0.980 0.992 0.046
ENSG00000108861 E012 366.216016 0.0015689625 0.004238791 0.01381052 17 43774712 43774881 170 - 2.589 2.518 -0.236
ENSG00000108861 E013 198.683621 0.0079640199 0.173649785 0.29293457 17 43774882 43774938 57 - 2.320 2.255 -0.217
ENSG00000108861 E014 1.821654 0.1486570089 0.457930401 0.59826727 17 43777529 43777813 285 - 0.538 0.400 -0.696
ENSG00000108861 E015 1.879941 0.0077452465 0.146069928 0.25634087 17 43777857 43778337 481 - 0.259 0.524 1.524
ENSG00000108861 E016 206.226258 0.0097005551 0.099477182 0.18967815 17 43778800 43778984 185 - 2.349 2.262 -0.288