ENSG00000108854

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262435 ENSG00000108854 HEK293_OSMI2_2hA HEK293_TMG_2hB SMURF2 protein_coding protein_coding 9.706513 3.3937 14.62975 0.08462102 0.9954345 2.104715 2.0482079 1.1280896 3.5324529 0.09319613 0.2031771 1.6381345 0.25180000 0.33340000 0.2420667 -0.09133333 1.587960e-01 8.886171e-08 FALSE TRUE
ENST00000585301 ENSG00000108854 HEK293_OSMI2_2hA HEK293_TMG_2hB SMURF2 protein_coding protein_coding 9.706513 3.3937 14.62975 0.08462102 0.9954345 2.104715 1.0693989 0.0000000 2.8398169 0.00000000 0.8286469 8.1547254 0.07455417 0.00000000 0.1963333 0.19633333 1.613221e-05 8.886171e-08 FALSE TRUE
MSTRG.14937.10 ENSG00000108854 HEK293_OSMI2_2hA HEK293_TMG_2hB SMURF2 protein_coding   9.706513 3.3937 14.62975 0.08462102 0.9954345 2.104715 0.4453356 0.2202635 0.2926733 0.12134253 0.2926733 0.3944755 0.05595833 0.06323333 0.0179000 -0.04533333 4.704327e-01 8.886171e-08 FALSE TRUE
MSTRG.14937.11 ENSG00000108854 HEK293_OSMI2_2hA HEK293_TMG_2hB SMURF2 protein_coding   9.706513 3.3937 14.62975 0.08462102 0.9954345 2.104715 2.3847672 0.0000000 2.9838831 0.00000000 0.7800102 8.2258741 0.18216667 0.00000000 0.2031333 0.20313333 8.886171e-08 8.886171e-08 FALSE TRUE
MSTRG.14937.3 ENSG00000108854 HEK293_OSMI2_2hA HEK293_TMG_2hB SMURF2 protein_coding   9.706513 3.3937 14.62975 0.08462102 0.9954345 2.104715 0.1668889 0.2771655 0.0000000 0.17902598 0.0000000 -4.8438105 0.02138750 0.08330000 0.0000000 -0.08330000 4.276905e-02 8.886171e-08 TRUE TRUE
MSTRG.14937.6 ENSG00000108854 HEK293_OSMI2_2hA HEK293_TMG_2hB SMURF2 protein_coding   9.706513 3.3937 14.62975 0.08462102 0.9954345 2.104715 2.5136977 1.5181716 3.7220097 0.18443262 0.2431381 1.2881462 0.29195000 0.44600000 0.2562667 -0.18973333 1.956685e-02 8.886171e-08 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000108854 E001 0.2955422 0.0297948701 4.261185e-01   17 64542282 64542294 13 - 0.075 0.194 1.592
ENSG00000108854 E002 13.8934289 0.0012804365 2.944105e-06 2.206995e-05 17 64542295 64542548 254 - 0.966 1.394 1.527
ENSG00000108854 E003 25.8956960 0.0013502369 6.324603e-06 4.400371e-05 17 64542549 64542666 118 - 1.274 1.596 1.111
ENSG00000108854 E004 24.6789204 0.0056022896 3.528377e-05 2.061052e-04 17 64542667 64542725 59 - 1.252 1.582 1.140
ENSG00000108854 E005 32.3935173 0.0077901556 2.421400e-03 8.525986e-03 17 64542726 64542794 69 - 1.404 1.641 0.812
ENSG00000108854 E006 38.9482688 0.0057775353 1.730202e-02 4.560756e-02 17 64542795 64542943 149 - 1.504 1.675 0.583
ENSG00000108854 E007 24.6254721 0.0008909460 8.985626e-02 1.749092e-01 17 64542944 64543009 66 - 1.327 1.458 0.454
ENSG00000108854 E008 18.4358961 0.0104606154 4.577305e-01 5.980474e-01 17 64543010 64543056 47 - 1.224 1.305 0.285
ENSG00000108854 E009 83.3210526 0.0070580564 1.874049e-01 3.104657e-01 17 64543057 64544465 1409 - 1.901 1.834 -0.228
ENSG00000108854 E010 13.4994812 0.0194952631 2.105805e-01 3.392276e-01 17 64544466 64544567 102 - 1.161 1.002 -0.574
ENSG00000108854 E011 12.8333582 0.0628397418 4.126084e-01 5.561657e-01 17 64544568 64544654 87 - 1.138 1.016 -0.441
ENSG00000108854 E012 24.7274807 0.0008166307 8.942943e-02 1.742624e-01 17 64544655 64545067 413 - 1.401 1.268 -0.462
ENSG00000108854 E013 31.3865782 0.0007719114 2.324041e-02 5.824615e-02 17 64545068 64545450 383 - 1.423 1.577 0.529
ENSG00000108854 E014 29.0463485 0.0014244685 2.530152e-09 3.481730e-08 17 64545451 64545490 40 - 1.287 1.685 1.371
ENSG00000108854 E015 27.1486075 0.0009149829 1.489251e-09 2.138189e-08 17 64545491 64545515 25 - 1.247 1.660 1.423
ENSG00000108854 E016 102.9716823 0.0024973424 2.012700e-09 2.814853e-08 17 64545516 64545947 432 - 1.886 2.142 0.860
ENSG00000108854 E017 57.7149658 0.0004394971 1.949745e-04 9.424230e-04 17 64546263 64546338 76 - 1.666 1.852 0.630
ENSG00000108854 E018 94.6432139 0.0057086214 1.207649e-01 2.210509e-01 17 64547600 64547801 202 - 1.912 1.994 0.275
ENSG00000108854 E019 83.5140396 0.0004009711 8.434381e-02 1.663714e-01 17 64551584 64551704 121 - 1.859 1.937 0.260
ENSG00000108854 E020 49.0495120 0.0008132224 1.276503e-01 2.308810e-01 17 64554856 64554880 25 - 1.627 1.715 0.299
ENSG00000108854 E021 85.3902509 0.0003577859 4.015877e-01 5.452874e-01 17 64554881 64554993 113 - 1.879 1.919 0.135
ENSG00000108854 E022 108.1113884 0.0009540988 8.316797e-01 8.945215e-01 17 64555820 64555998 179 - 1.990 2.003 0.043
ENSG00000108854 E023 53.8521537 0.0004262684 5.638152e-01 6.912261e-01 17 64557608 64557640 33 - 1.685 1.720 0.120
ENSG00000108854 E024 55.4270280 0.0004565684 2.197140e-01 3.500476e-01 17 64557641 64557722 82 - 1.688 1.756 0.230
ENSG00000108854 E025 0.1472490 0.0455127552 1.000000e+00   17 64560748 64560839 92 - 0.075 0.000 -8.668
ENSG00000108854 E026 0.0000000       17 64560840 64560958 119 -      
ENSG00000108854 E027 63.2456873 0.0004238968 8.765540e-01 9.247676e-01 17 64561500 64561603 104 - 1.763 1.760 -0.009
ENSG00000108854 E028 69.5423973 0.0003357551 6.036975e-02 1.272403e-01 17 64562771 64562882 112 - 1.828 1.743 -0.288
ENSG00000108854 E029 70.1643638 0.0003414012 3.537488e-04 1.594583e-03 17 64562883 64562966 84 - 1.853 1.681 -0.581
ENSG00000108854 E030 0.4482035 0.0247807792 4.348604e-01 5.771178e-01 17 64562967 64563165 199 - 0.194 0.000 -10.253
ENSG00000108854 E031 80.9711202 0.0004030357 4.187498e-06 3.030905e-05 17 64571798 64571956 159 - 1.919 1.706 -0.720
ENSG00000108854 E032 67.4674313 0.0004338760 1.579187e-02 4.226671e-02 17 64578492 64578576 85 - 1.821 1.706 -0.389
ENSG00000108854 E033 101.3674610 0.0002636979 2.626306e-04 1.227266e-03 17 64580789 64580991 203 - 2.003 1.859 -0.483
ENSG00000108854 E034 58.6234503 0.0004900331 4.298001e-04 1.889196e-03 17 64583461 64583544 84 - 1.778 1.590 -0.638
ENSG00000108854 E035 63.6422068 0.0003773316 9.282391e-06 6.216161e-05 17 64586086 64586170 85 - 1.822 1.590 -0.786
ENSG00000108854 E036 65.6083955 0.0004288985 1.819281e-05 1.139401e-04 17 64591084 64591149 66 - 1.834 1.614 -0.744
ENSG00000108854 E037 0.0000000       17 64593015 64593439 425 -      
ENSG00000108854 E038 71.5124600 0.0014205575 6.597469e-08 6.941027e-07 17 64593440 64593573 134 - 1.884 1.596 -0.974
ENSG00000108854 E039 2.1598700 0.0891285176 4.151415e-01 5.585588e-01 17 64593991 64594104 114 - 0.511 0.330 -0.976
ENSG00000108854 E040 37.6888365 0.0010224353 4.822611e-04 2.092265e-03 17 64598382 64598490 109 - 1.602 1.363 -0.821
ENSG00000108854 E041 14.3297710 0.0012475233 7.817987e-03 2.332358e-02 17 64606602 64606640 39 - 1.209 0.922 -1.045
ENSG00000108854 E042 0.8772652 0.1169462207 1.579064e-01 2.723399e-01 17 64613869 64613926 58 - 0.327 0.000 -11.249
ENSG00000108854 E043 0.1472490 0.0455127552 1.000000e+00   17 64660747 64660862 116 - 0.075 0.000 -8.668
ENSG00000108854 E044 35.9698975 0.0006102828 1.401950e-06 1.127410e-05 17 64661829 64662307 479 - 1.597 1.241 -1.233