ENSG00000108799

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000428826 ENSG00000108799 HEK293_OSMI2_2hA HEK293_TMG_2hB EZH1 protein_coding protein_coding 12.02699 9.959654 9.527213 0.5774691 0.2886791 -0.06397576 5.0910987 4.8857764 3.360519 0.08203398 0.35558121 -0.5385671 0.4220833 0.49320000 0.3515000 -0.141700000 4.530027e-02 8.761065e-09 FALSE TRUE
ENST00000586089 ENSG00000108799 HEK293_OSMI2_2hA HEK293_TMG_2hB EZH1 protein_coding protein_coding 12.02699 9.959654 9.527213 0.5774691 0.2886791 -0.06397576 0.6656142 0.2727545 1.328927 0.11494037 0.35491696 2.2434552 0.0576250 0.02660000 0.1379000 0.111300000 6.726915e-03 8.761065e-09 FALSE FALSE
ENST00000586103 ENSG00000108799 HEK293_OSMI2_2hA HEK293_TMG_2hB EZH1 protein_coding retained_intron 12.02699 9.959654 9.527213 0.5774691 0.2886791 -0.06397576 1.2049675 0.7339659 1.086857 0.11898994 0.09255276 0.5600670 0.1004125 0.07276667 0.1148667 0.042100000 2.007880e-01 8.761065e-09 FALSE TRUE
ENST00000586714 ENSG00000108799 HEK293_OSMI2_2hA HEK293_TMG_2hB EZH1 protein_coding retained_intron 12.02699 9.959654 9.527213 0.5774691 0.2886791 -0.06397576 3.3773461 2.6563685 2.411380 0.46322898 0.20765864 -0.1390468 0.2753167 0.26333333 0.2548000 -0.008533333 9.722573e-01 8.761065e-09   FALSE
ENST00000593148 ENSG00000108799 HEK293_OSMI2_2hA HEK293_TMG_2hB EZH1 protein_coding retained_intron 12.02699 9.959654 9.527213 0.5774691 0.2886791 -0.06397576 0.3237989 0.5691566 0.000000 0.11713985 0.00000000 -5.8558817 0.0294250 0.05610000 0.0000000 -0.056100000 8.761065e-09 8.761065e-09   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000108799 E001 380.7671752 0.0060529051 4.404370e-10 6.967805e-09 17 42700275 42702291 2017 - 2.415 2.667 0.841
ENSG00000108799 E002 32.7751423 0.0006362023 3.043047e-01 4.463219e-01 17 42702292 42702324 33 - 1.456 1.561 0.359
ENSG00000108799 E003 37.9014788 0.0006639269 2.310664e-01 3.637445e-01 17 42702325 42702380 56 - 1.515 1.625 0.378
ENSG00000108799 E004 22.6481495 0.0009492964 4.155570e-01 5.589352e-01 17 42702381 42702384 4 - 1.307 1.408 0.350
ENSG00000108799 E005 60.3179995 0.0004458789 2.070939e-01 3.350492e-01 17 42702385 42702592 208 - 1.719 1.819 0.338
ENSG00000108799 E006 41.1990790 0.0006858948 4.182585e-01 5.615402e-01 17 42702877 42702961 85 - 1.566 1.653 0.295
ENSG00000108799 E007 33.2384293 0.0007619218 1.521153e-01 2.645599e-01 17 42702962 42703169 208 - 1.445 1.575 0.445
ENSG00000108799 E008 27.2859716 0.0300249454 6.978355e-01 7.978735e-01 17 42703193 42703422 230 - 1.394 1.474 0.278
ENSG00000108799 E009 9.5002719 0.0027523019 5.131536e-01 6.479875e-01 17 42703423 42703426 4 - 1.027 0.997 -0.113
ENSG00000108799 E010 10.1634893 0.0017730618 6.605859e-01 7.692252e-01 17 42703427 42703458 32 - 1.041 1.035 -0.022
ENSG00000108799 E011 29.1232785 0.0074199246 5.018363e-01 6.379816e-01 17 42703459 42703739 281 - 1.412 1.504 0.319
ENSG00000108799 E012 24.9639257 0.0091555357 3.935741e-01 5.374649e-01 17 42703740 42703790 51 - 1.343 1.452 0.378
ENSG00000108799 E013 21.2073657 0.0114388791 8.735944e-01 9.227604e-01 17 42703791 42703820 30 - 1.308 1.359 0.180
ENSG00000108799 E014 30.0267304 0.0008356058 4.935252e-01 6.305428e-01 17 42704602 42704683 82 - 1.486 1.484 -0.006
ENSG00000108799 E015 23.9005807 0.0008063231 6.624414e-01 7.707483e-01 17 42705088 42705183 96 - 1.382 1.392 0.036
ENSG00000108799 E016 0.9566832 0.0132582337 5.771717e-01 7.024686e-01 17 42705583 42706006 424 - 0.228 0.348 0.833
ENSG00000108799 E017 24.1843890 0.0008222113 5.223112e-02 1.131300e-01 17 42706007 42706113 107 - 1.451 1.358 -0.319
ENSG00000108799 E018 22.1098725 0.0100651747 4.367065e-01 5.787448e-01 17 42706114 42706185 72 - 1.369 1.343 -0.091
ENSG00000108799 E019 19.2615953 0.0401418496 2.721751e-01 4.110257e-01 17 42707958 42708002 45 - 1.349 1.254 -0.331
ENSG00000108799 E020 18.4366969 0.0047843384 1.664129e-01 2.835314e-01 17 42708003 42708044 42 - 1.322 1.246 -0.265
ENSG00000108799 E021 17.1476701 0.0019887339 6.927827e-01 7.939315e-01 17 42708045 42708083 39 - 1.208 1.282 0.259
ENSG00000108799 E022 17.6506824 0.0052112394 8.901300e-01 9.338018e-01 17 42708876 42708916 41 - 1.253 1.281 0.100
ENSG00000108799 E023 0.2955422 0.0298818416 8.747512e-01   17 42708917 42709182 266 - 0.129 0.116 -0.167
ENSG00000108799 E024 0.2966881 0.0290785164 1.496970e-01   17 42709544 42709845 302 - 0.228 0.000 -13.138
ENSG00000108799 E025 20.8549499 0.0054280332 2.567018e-01 3.936681e-01 17 42709846 42709937 92 - 1.369 1.320 -0.170
ENSG00000108799 E026 18.2528774 0.0010119456 4.571384e-01 5.975004e-01 17 42712289 42712341 53 - 1.292 1.275 -0.062
ENSG00000108799 E027 29.6502149 0.0007330293 3.026710e-03 1.034469e-02 17 42712342 42712485 144 - 1.558 1.413 -0.497
ENSG00000108799 E028 26.8628714 0.0007465676 3.762449e-03 1.247588e-02 17 42713209 42713375 167 - 1.519 1.370 -0.514
ENSG00000108799 E029 11.5456783 0.0014719388 5.229769e-02 1.132509e-01 17 42713376 42713389 14 - 1.170 1.022 -0.532
ENSG00000108799 E030 12.7272219 0.0013529889 4.629282e-04 2.017863e-03 17 42717976 42718005 30 - 1.269 0.983 -1.029
ENSG00000108799 E031 18.4000865 0.0012564987 6.143627e-04 2.586081e-03 17 42718006 42718067 62 - 1.400 1.171 -0.802
ENSG00000108799 E032 1.9593378 0.1068253676 8.119716e-01 8.807094e-01 17 42718068 42718100 33 - 0.487 0.490 0.015
ENSG00000108799 E033 8.8536652 0.0031176563 1.681110e-01 2.857384e-01 17 42718101 42718453 353 - 0.878 1.070 0.715
ENSG00000108799 E034 30.3341722 0.0010134364 1.246573e-02 3.465545e-02 17 42718454 42718617 164 - 1.550 1.434 -0.399
ENSG00000108799 E035 27.4837166 0.0035783503 6.279636e-02 1.313712e-01 17 42719105 42719207 103 - 1.501 1.413 -0.303
ENSG00000108799 E036 20.9917867 0.0009426615 6.226526e-01 7.394107e-01 17 42720273 42720307 35 - 1.336 1.340 0.016
ENSG00000108799 E037 36.3350403 0.0022215986 5.497147e-02 1.179422e-01 17 42720308 42720437 130 - 1.605 1.531 -0.254
ENSG00000108799 E038 18.7667075 0.0073984577 2.441048e-01 3.790225e-01 17 42720438 42720449 12 - 1.322 1.261 -0.211
ENSG00000108799 E039 37.1236719 0.0084717113 3.465543e-03 1.162670e-02 17 42722795 42722915 121 - 1.664 1.501 -0.557
ENSG00000108799 E040 22.3559558 0.0008907414 1.570518e-02 4.207452e-02 17 42724305 42724350 46 - 1.434 1.302 -0.459
ENSG00000108799 E041 27.6102100 0.0007197435 9.250171e-02 1.790318e-01 17 42724351 42724424 74 - 1.491 1.423 -0.233
ENSG00000108799 E042 0.4417471 0.6771990134 2.396327e-01 3.736743e-01 17 42724425 42724614 190 - 0.308 0.000 -10.657
ENSG00000108799 E043 21.2455750 0.0009039990 2.001796e-01 3.264758e-01 17 42727635 42727661 27 - 1.369 1.315 -0.187
ENSG00000108799 E044 31.8242146 0.0017589404 2.509984e-02 6.208174e-02 17 42727662 42727763 102 - 1.562 1.462 -0.342
ENSG00000108799 E045 31.1954555 0.0007561190 6.097057e-03 1.886536e-02 17 42728825 42728952 128 - 1.570 1.443 -0.436
ENSG00000108799 E046 0.0000000       17 42729147 42729239 93 -      
ENSG00000108799 E047 19.7817499 0.0009530737 2.325159e-03 8.228924e-03 17 42730828 42730918 91 - 1.406 1.214 -0.670
ENSG00000108799 E048 0.0000000       17 42731775 42731893 119 -      
ENSG00000108799 E049 11.1787798 0.0015882697 1.119724e-07 1.127562e-06 17 42745011 42745049 39 - 1.292 0.794 -1.832