ENSG00000108797

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000264638 ENSG00000108797 HEK293_OSMI2_2hA HEK293_TMG_2hB CNTNAP1 protein_coding protein_coding 1.489233 1.114457 1.165341 0.1791585 0.1406062 0.06385085 0.9206959 0.7736043 0.4309971 0.05068995 0.16988888 -0.8293562 0.603925 0.7353333 0.4105333 -0.32480000 0.38890408 0.03185864 FALSE TRUE
ENST00000586801 ENSG00000108797 HEK293_OSMI2_2hA HEK293_TMG_2hB CNTNAP1 protein_coding retained_intron 1.489233 1.114457 1.165341 0.1791585 0.1406062 0.06385085 0.4128807 0.1649690 0.4358826 0.06085321 0.01054283 1.3495644 0.268625 0.1407667 0.3823667 0.24160000 0.03185864 0.03185864   FALSE
ENST00000591662 ENSG00000108797 HEK293_OSMI2_2hA HEK293_TMG_2hB CNTNAP1 protein_coding nonsense_mediated_decay 1.489233 1.114457 1.165341 0.1791585 0.1406062 0.06385085 0.1390700 0.1758841 0.2559309 0.17588413 0.25593093 0.5166480 0.116000 0.1239333 0.1776000 0.05366667 1.00000000 0.03185864 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000108797 E001 1.5833569 0.019270149 2.708097e-01 4.094696e-01 17 42682531 42682698 168 + 0.517 0.324 -1.046
ENSG00000108797 E002 3.8235728 0.004461662 7.759473e-01 8.557111e-01 17 42682699 42682896 198 + 0.647 0.689 0.177
ENSG00000108797 E003 4.5567966 0.004390290 5.303393e-01 6.629574e-01 17 42683821 42683922 102 + 0.775 0.689 -0.352
ENSG00000108797 E004 5.3862781 0.003295813 5.868067e-01 7.102755e-01 17 42684036 42684229 194 + 0.828 0.757 -0.279
ENSG00000108797 E005 4.1276227 0.003986755 5.528899e-01 6.821137e-01 17 42684991 42685138 148 + 0.747 0.663 -0.345
ENSG00000108797 E006 4.4157770 0.049180552 8.174238e-01 8.845559e-01 17 42685217 42685420 204 + 0.746 0.712 -0.141
ENSG00000108797 E007 4.8942541 0.010392086 5.142464e-01 6.489811e-01 17 42685957 42686141 185 + 0.683 0.779 0.393
ENSG00000108797 E008 6.3003740 0.024504420 7.619696e-01 8.456870e-01 17 42686903 42687046 144 + 0.852 0.821 -0.119
ENSG00000108797 E009 5.0469336 0.003331818 1.228109e-02 3.420637e-02 17 42687261 42687719 459 + 0.936 0.608 -1.322
ENSG00000108797 E010 9.3981045 0.002052909 4.369721e-02 9.783033e-02 17 42687720 42687981 262 + 1.121 0.915 -0.760
ENSG00000108797 E011 8.5521491 0.002134029 8.622844e-02 1.693597e-01 17 42688462 42688611 150 + 1.068 0.884 -0.682
ENSG00000108797 E012 3.9269033 0.006248394 4.431870e-01 5.847477e-01 17 42688876 42689047 172 + 0.747 0.637 -0.460
ENSG00000108797 E013 7.5913106 0.005800277 3.585666e-01 5.029793e-01 17 42689521 42689627 107 + 0.973 0.869 -0.393
ENSG00000108797 E014 0.1451727 0.044277050 3.592938e-01   17 42689778 42690087 310 + 0.140 0.000 -8.826
ENSG00000108797 E015 7.4920086 0.002303966 2.210113e-01 3.516324e-01 17 42690088 42690207 120 + 0.990 0.852 -0.524
ENSG00000108797 E016 9.4722715 0.001889432 3.503429e-01 4.945294e-01 17 42690739 42690942 204 + 1.053 0.957 -0.356
ENSG00000108797 E017 3.0593168 0.062657136 8.215121e-01 8.874450e-01 17 42691137 42691152 16 + 0.565 0.609 0.198
ENSG00000108797 E018 7.6007724 0.002586286 8.767902e-01 9.249242e-01 17 42691153 42691293 141 + 0.917 0.900 -0.062
ENSG00000108797 E019 7.2311227 0.008588565 3.110469e-01 4.534862e-01 17 42691384 42691511 128 + 0.955 0.836 -0.453
ENSG00000108797 E020 11.2268098 0.001748860 4.169505e-01 5.603440e-01 17 42691806 42691991 186 + 1.108 1.030 -0.283
ENSG00000108797 E021 12.0704135 0.030414560 4.635262e-01 6.033210e-01 17 42692499 42692720 222 + 1.157 1.064 -0.334
ENSG00000108797 E022 12.6048872 0.049120086 6.063993e-01 7.265569e-01 17 42693297 42693536 240 + 1.081 1.136 0.198
ENSG00000108797 E023 15.1247781 0.001342718 1.587538e-01 2.734752e-01 17 42695521 42695874 354 + 1.108 1.233 0.444
ENSG00000108797 E024 10.9709076 0.020215827 4.244685e-01 5.674405e-01 17 42696025 42696152 128 + 1.007 1.101 0.341
ENSG00000108797 E025 10.5552615 0.001793268 9.004496e-01 9.404977e-01 17 42697274 42697367 94 + 1.038 1.052 0.049
ENSG00000108797 E026 16.9495417 0.011042862 6.242100e-01 7.406102e-01 17 42697554 42697799 246 + 1.212 1.259 0.169
ENSG00000108797 E027 7.5618340 0.002553321 4.432935e-01 5.848559e-01 17 42697903 42697950 48 + 0.852 0.943 0.348
ENSG00000108797 E028 38.3983829 0.001826946 3.731367e-06 2.735455e-05 17 42698618 42700012 1395 + 1.379 1.656 0.950