ENSG00000108788

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000346833 ENSG00000108788 HEK293_OSMI2_2hA HEK293_TMG_2hB MLX protein_coding protein_coding 39.72034 50.49411 31.93889 1.769049 0.7262966 -0.6606352 5.306253 9.271867 5.538655 0.1912731 0.5252361 -0.74227675 0.12976250 0.18426667 0.17340000 -0.01086667 8.717682e-01 3.962264e-08 FALSE TRUE
ENST00000435881 ENSG00000108788 HEK293_OSMI2_2hA HEK293_TMG_2hB MLX protein_coding protein_coding 39.72034 50.49411 31.93889 1.769049 0.7262966 -0.6606352 22.071456 29.687110 14.231387 1.3182410 0.3826605 -1.06023291 0.54929167 0.58770000 0.44600000 -0.14170000 2.671829e-05 3.962264e-08 FALSE TRUE
ENST00000590050 ENSG00000108788 HEK293_OSMI2_2hA HEK293_TMG_2hB MLX protein_coding retained_intron 39.72034 50.49411 31.93889 1.769049 0.7262966 -0.6606352 2.287463 1.206060 2.006920 0.2253232 0.3210423 0.72993936 0.06085833 0.02400000 0.06326667 0.03926667 2.008385e-02 3.962264e-08 TRUE TRUE
ENST00000590084 ENSG00000108788 HEK293_OSMI2_2hA HEK293_TMG_2hB MLX protein_coding retained_intron 39.72034 50.49411 31.93889 1.769049 0.7262966 -0.6606352 2.066444 1.588890 1.891884 0.2584991 0.1763322 0.25035818 0.05375000 0.03173333 0.05936667 0.02763333 8.522215e-02 3.962264e-08   FALSE
ENST00000591024 ENSG00000108788 HEK293_OSMI2_2hA HEK293_TMG_2hB MLX protein_coding protein_coding 39.72034 50.49411 31.93889 1.769049 0.7262966 -0.6606352 3.671474 3.780804 3.992460 0.6159625 0.4123691 0.07838295 0.09562500 0.07433333 0.12453333 0.05020000 6.422789e-02 3.962264e-08 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000108788 E001 1.217668 0.2738535352 8.048934e-01 8.758501e-01 17 42567039 42567071 33 + 0.285 0.362 0.491
ENSG00000108788 E002 1.217668 0.2738535352 8.048934e-01 8.758501e-01 17 42567072 42567073 2 + 0.285 0.362 0.493
ENSG00000108788 E003 9.634624 0.0281071923 2.169889e-01 3.467763e-01 17 42567074 42567098 25 + 1.100 0.950 -0.552
ENSG00000108788 E004 10.482755 0.0186960824 1.937670e-01 3.185127e-01 17 42567099 42567099 1 + 1.131 0.983 -0.539
ENSG00000108788 E005 10.849372 0.0109942353 1.604976e-01 2.757945e-01 17 42567100 42567101 2 + 1.145 0.994 -0.549
ENSG00000108788 E006 12.661447 0.0017631274 2.089001e-01 3.372059e-01 17 42567102 42567102 1 + 1.187 1.069 -0.422
ENSG00000108788 E007 43.250031 0.0124360584 4.875029e-03 1.558145e-02 17 42567103 42567116 14 + 1.746 1.543 -0.691
ENSG00000108788 E008 179.082299 0.0002646365 5.992724e-01 7.207133e-01 17 42567117 42567160 44 + 2.204 2.222 0.059
ENSG00000108788 E009 177.951311 0.0002886226 5.686451e-01 6.952668e-01 17 42567161 42567166 6 + 2.200 2.220 0.064
ENSG00000108788 E010 30.295793 0.0017122025 9.431383e-01 9.683427e-01 17 42567167 42567280 114 + 1.453 1.460 0.025
ENSG00000108788 E011 34.649614 0.0068644209 6.362459e-01 7.502947e-01 17 42567281 42567328 48 + 1.487 1.523 0.125
ENSG00000108788 E012 250.254673 0.0013149400 7.111835e-01 8.081842e-01 17 42567619 42567655 37 + 2.367 2.358 -0.030
ENSG00000108788 E013 13.825612 0.0012569087 4.155879e-06 3.010549e-05 17 42567656 42568076 421 + 1.375 0.965 -1.466
ENSG00000108788 E014 7.113777 0.0022799467 9.059093e-03 2.642572e-02 17 42568077 42568469 393 + 1.067 0.763 -1.153
ENSG00000108788 E015 229.958887 0.0001827858 8.746073e-02 1.712844e-01 17 42568470 42568559 90 + 2.292 2.338 0.154
ENSG00000108788 E016 28.028183 0.0049088111 3.020342e-11 5.815579e-10 17 42568560 42568836 277 + 1.700 1.224 -1.642
ENSG00000108788 E017 397.047590 0.0001523131 6.420109e-02 1.336987e-01 17 42568837 42568943 107 + 2.582 2.550 -0.108
ENSG00000108788 E018 382.113104 0.0002022763 1.335583e-03 5.095090e-03 17 42569204 42569303 100 + 2.584 2.525 -0.199
ENSG00000108788 E019 23.040950 0.0051546541 2.739039e-12 6.263159e-11 17 42569304 42569506 203 + 1.649 1.109 -1.877
ENSG00000108788 E020 427.101062 0.0004804789 2.453643e-01 3.804638e-01 17 42569507 42569606 100 + 2.606 2.584 -0.073
ENSG00000108788 E021 17.787726 0.0010507324 6.159550e-01 7.341044e-01 17 42569607 42569981 375 + 1.259 1.218 -0.143
ENSG00000108788 E022 503.754899 0.0001407211 7.631196e-01 8.465567e-01 17 42569982 42570096 115 + 2.665 2.662 -0.009
ENSG00000108788 E023 446.121705 0.0002060440 2.192508e-02 5.551893e-02 17 42570097 42570183 87 + 2.577 2.621 0.148
ENSG00000108788 E024 1442.321604 0.0002797884 1.300449e-07 1.292389e-06 17 42571547 42573239 1693 + 3.079 3.135 0.187