ENSG00000108671

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261712 ENSG00000108671 HEK293_OSMI2_2hA HEK293_TMG_2hB PSMD11 protein_coding protein_coding 57.68868 59.5164 58.07877 5.909043 0.6802046 -0.03527041 23.802905 37.3245261 16.178345 3.1266641 0.7376186 -1.2055549 0.41632083 0.631266667 0.27843333 -0.35283333 2.666862e-09 3.250773e-30 FALSE TRUE
ENST00000457654 ENSG00000108671 HEK293_OSMI2_2hA HEK293_TMG_2hB PSMD11 protein_coding protein_coding 57.68868 59.5164 58.07877 5.909043 0.6802046 -0.03527041 9.390213 9.6363820 7.882447 0.3773510 0.2243065 -0.2895152 0.16510417 0.165300000 0.13586667 -0.02943333 5.370464e-01 3.250773e-30 FALSE TRUE
ENST00000578397 ENSG00000108671 HEK293_OSMI2_2hA HEK293_TMG_2hB PSMD11 protein_coding retained_intron 57.68868 59.5164 58.07877 5.909043 0.6802046 -0.03527041 6.150880 0.3786491 9.813999 0.1528549 0.3054854 4.6597703 0.10468750 0.006066667 0.16893333 0.16286667 3.250773e-30 3.250773e-30 FALSE TRUE
ENST00000649012 ENSG00000108671 HEK293_OSMI2_2hA HEK293_TMG_2hB PSMD11 protein_coding protein_coding 57.68868 59.5164 58.07877 5.909043 0.6802046 -0.03527041 3.718630 6.1670427 3.900827 0.9968502 0.4747222 -0.6594425 0.06362083 0.102900000 0.06713333 -0.03576667 1.181283e-01 3.250773e-30 FALSE TRUE
MSTRG.14119.5 ENSG00000108671 HEK293_OSMI2_2hA HEK293_TMG_2hB PSMD11 protein_coding   57.68868 59.5164 58.07877 5.909043 0.6802046 -0.03527041 12.574324 4.2046523 18.541825 3.6920072 0.4635827 2.1380756 0.21290000 0.061033333 0.31946667 0.25843333 1.550319e-01 3.250773e-30 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000108671 E001 0.6934063 0.0842671847 9.612647e-02 1.845554e-01 17 32444379 32444460 82 + 0.000 0.328 11.800
ENSG00000108671 E002 0.6934063 0.0842671847 9.612647e-02 1.845554e-01 17 32444461 32444473 13 + 0.000 0.328 11.815
ENSG00000108671 E003 48.0397026 0.0109235615 1.290925e-02 3.570194e-02 17 32444474 32444503 30 + 1.763 1.615 -0.502
ENSG00000108671 E004 51.3580049 0.0107054964 1.000698e-02 2.877906e-02 17 32444504 32444504 1 + 1.793 1.642 -0.513
ENSG00000108671 E005 64.2018294 0.0026096658 2.104169e-04 1.008471e-03 17 32444505 32444509 5 + 1.889 1.738 -0.512
ENSG00000108671 E006 70.5393784 0.0042592293 1.192142e-03 4.614412e-03 17 32444510 32444511 2 + 1.922 1.785 -0.462
ENSG00000108671 E007 102.9110845 0.0051539399 1.483612e-04 7.399000e-04 17 32444512 32444518 7 + 2.093 1.938 -0.521
ENSG00000108671 E008 321.3373871 0.0050973849 5.960195e-04 2.518886e-03 17 32444519 32444614 96 + 2.556 2.455 -0.339
ENSG00000108671 E009 0.6976476 0.1160948722 7.598652e-01 8.441130e-01 17 32445667 32445987 321 + 0.243 0.196 -0.396
ENSG00000108671 E010 442.4153163 0.0029345408 7.932121e-05 4.246761e-04 17 32446945 32447046 102 + 2.687 2.601 -0.286
ENSG00000108671 E011 0.9694704 0.8132965591 6.311495e-01 7.462363e-01 17 32447047 32447333 287 + 0.401 0.196 -1.412
ENSG00000108671 E012 473.1203160 0.0017362344 2.183211e-04 1.042293e-03 17 32454495 32454619 125 + 2.702 2.642 -0.200
ENSG00000108671 E013 2.4880933 0.1931704214 6.115299e-01 7.306356e-01 17 32454752 32454877 126 + 0.604 0.503 -0.466
ENSG00000108671 E014 363.4715829 0.0005527583 4.011965e-03 1.317618e-02 17 32464049 32464120 72 + 2.568 2.541 -0.092
ENSG00000108671 E015 322.4428588 0.0008927639 5.105319e-03 1.621682e-02 17 32464521 32464578 58 + 2.520 2.486 -0.114
ENSG00000108671 E016 406.7856536 0.0002383106 3.137782e-05 1.857828e-04 17 32468999 32469071 73 + 2.626 2.582 -0.146
ENSG00000108671 E017 485.9217867 0.0015868305 1.020962e-03 4.031646e-03 17 32469072 32469193 122 + 2.705 2.656 -0.164
ENSG00000108671 E018 617.6712952 0.0006639686 3.588371e-05 2.091736e-04 17 32473801 32473945 145 + 2.807 2.764 -0.141
ENSG00000108671 E019 2.0753537 0.1671751991 1.310713e-01 2.356424e-01 17 32473946 32474081 136 + 0.641 0.373 -1.315
ENSG00000108671 E020 471.1463993 0.0004369789 3.215702e-03 1.090203e-02 17 32474764 32474824 61 + 2.678 2.657 -0.069
ENSG00000108671 E021 23.1345422 0.0071009373 2.492296e-05 1.511825e-04 17 32476680 32477520 841 + 1.537 1.232 -1.058
ENSG00000108671 E022 458.6391103 0.0001486254 1.653294e-02 4.391268e-02 17 32477521 32477583 63 + 2.658 2.652 -0.021
ENSG00000108671 E023 1.9823408 0.0086759849 5.379298e-01 6.694070e-01 17 32477584 32477829 246 + 0.512 0.430 -0.409
ENSG00000108671 E024 600.9697722 0.0001359875 8.130999e-02 1.616006e-01 17 32479251 32479376 126 + 2.765 2.773 0.027
ENSG00000108671 E025 11.5991277 0.0014511498 7.537608e-05 4.060560e-04 17 32479377 32479850 474 + 1.270 0.921 -1.265
ENSG00000108671 E026 376.6062275 0.0001323087 3.015838e-01 4.434056e-01 17 32479851 32479886 36 + 2.558 2.573 0.051
ENSG00000108671 E027 7.1783221 0.0022375519 1.758451e-01 2.957818e-01 17 32479887 32480077 191 + 0.984 0.858 -0.475
ENSG00000108671 E028 6.7847996 0.0097333507 1.097669e-02 3.110771e-02 17 32480078 32480145 68 + 1.032 0.742 -1.109
ENSG00000108671 E029 450.7815901 0.0001576962 7.472887e-01 8.348219e-01 17 32480146 32480191 46 + 2.619 2.660 0.134
ENSG00000108671 E030 325.0148547 0.0001480093 8.448379e-01 9.034522e-01 17 32480192 32480197 6 + 2.479 2.517 0.129
ENSG00000108671 E031 4.8841928 0.0666710563 6.634878e-01 7.715355e-01 17 32480198 32480488 291 + 0.797 0.740 -0.230
ENSG00000108671 E032 710.7806452 0.0003877639 9.732853e-01 9.873163e-01 17 32480489 32480631 143 + 2.821 2.854 0.111
ENSG00000108671 E033 84.3988070 0.0056055240 3.751688e-01 5.195777e-01 17 32480632 32480752 121 + 1.870 1.950 0.267
ENSG00000108671 E034 953.8380319 0.0001077326 2.918767e-05 1.741580e-04 17 32480753 32481310 558 + 2.916 3.002 0.284
ENSG00000108671 E035 1976.9560974 0.0057079692 6.962986e-12 1.488845e-10 17 32481311 32483319 2009 + 3.112 3.365 0.840