ENSG00000108669

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000361101 ENSG00000108669 HEK293_OSMI2_2hA HEK293_TMG_2hB CYTH1 protein_coding protein_coding 16.22823 20.45291 12.28798 1.251451 0.3805173 -0.7345901 5.3109089 6.56782290 4.385597 0.14981445 0.2547676 -0.5815511 0.32923750 0.324600000 0.3571000 0.03250000 7.516753e-01 4.497244e-05 FALSE TRUE
ENST00000446868 ENSG00000108669 HEK293_OSMI2_2hA HEK293_TMG_2hB CYTH1 protein_coding protein_coding 16.22823 20.45291 12.28798 1.251451 0.3805173 -0.7345901 5.2028590 6.56782290 3.755156 0.14981445 0.3805800 -0.8049005 0.32160833 0.324600000 0.3074333 -0.01716667 9.197575e-01 4.497244e-05 FALSE TRUE
ENST00000586299 ENSG00000108669 HEK293_OSMI2_2hA HEK293_TMG_2hB CYTH1 protein_coding retained_intron 16.22823 20.45291 12.28798 1.251451 0.3805173 -0.7345901 1.8383533 1.64650933 1.231992 0.28184350 0.1177191 -0.4154903 0.10838333 0.080400000 0.1002000 0.01980000 6.162351e-01 4.497244e-05 FALSE FALSE
ENST00000589296 ENSG00000108669 HEK293_OSMI2_2hA HEK293_TMG_2hB CYTH1 protein_coding protein_coding 16.22823 20.45291 12.28798 1.251451 0.3805173 -0.7345901 0.5997317 2.25716529 0.000000 1.18805630 0.0000000 -7.8247458 0.02890417 0.103800000 0.0000000 -0.10380000 1.890695e-01 4.497244e-05 FALSE FALSE
ENST00000591455 ENSG00000108669 HEK293_OSMI2_2hA HEK293_TMG_2hB CYTH1 protein_coding protein_coding 16.22823 20.45291 12.28798 1.251451 0.3805173 -0.7345901 1.7636947 2.32203799 1.172016 0.35838528 0.1722963 -0.9803415 0.11026667 0.114300000 0.0953000 -0.01900000 7.718078e-01 4.497244e-05 FALSE TRUE
MSTRG.15182.10 ENSG00000108669 HEK293_OSMI2_2hA HEK293_TMG_2hB CYTH1 protein_coding   16.22823 20.45291 12.28798 1.251451 0.3805173 -0.7345901 0.8084309 0.05551693 1.418068 0.05551693 0.3403765 4.4460530 0.05938333 0.002533333 0.1139667 0.11143333 4.497244e-05 4.497244e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000108669 E001 0.5180316 0.0211915696 2.024781e-01 3.293144e-01 17 78674048 78674048 1 - 0.000 0.250 10.222
ENSG00000108669 E002 749.9311894 0.0028720383 3.132910e-19 1.831288e-17 17 78674049 78675655 1607 - 2.675 2.926 0.834
ENSG00000108669 E003 101.2253111 0.0004589206 2.446845e-06 1.867486e-05 17 78675656 78675819 164 - 1.829 2.049 0.742
ENSG00000108669 E004 61.2467146 0.0062751728 1.092952e-02 3.099231e-02 17 78675820 78675847 28 - 1.633 1.825 0.649
ENSG00000108669 E005 91.7612188 0.0004319430 1.366237e-04 6.885595e-04 17 78675848 78675962 115 - 1.810 2.000 0.641
ENSG00000108669 E006 112.6208727 0.0002655962 1.871803e-02 4.871717e-02 17 78675963 78676118 156 - 1.951 2.071 0.401
ENSG00000108669 E007 85.2492374 0.0005377653 7.248055e-01 8.182416e-01 17 78676119 78676169 51 - 1.901 1.924 0.076
ENSG00000108669 E008 47.6408931 0.0114773428 5.513644e-01 6.808435e-01 17 78676170 78676994 825 - 1.665 1.658 -0.025
ENSG00000108669 E009 11.5967224 0.0166037639 9.737328e-01 9.876207e-01 17 78676995 78677050 56 - 1.049 1.087 0.139
ENSG00000108669 E010 54.1437765 0.0131907191 1.071780e-02 3.049556e-02 17 78677051 78678471 1421 - 1.807 1.658 -0.503
ENSG00000108669 E011 62.0848463 0.0023844678 9.140740e-01 9.495743e-01 17 78680190 78680218 29 - 1.754 1.797 0.144
ENSG00000108669 E012 126.3291263 0.0003215530 1.112461e-01 2.073804e-01 17 78680219 78680344 126 - 2.094 2.078 -0.051
ENSG00000108669 E013 101.2557219 0.0008241671 4.413800e-02 9.863883e-02 17 78680971 78681042 72 - 2.012 1.972 -0.134
ENSG00000108669 E014 0.3729606 0.0316506226 6.998320e-01 7.994518e-01 17 78681043 78681066 24 - 0.148 0.101 -0.645
ENSG00000108669 E015 104.3941254 0.0002910482 6.074625e-03 1.880762e-02 17 78692417 78692493 77 - 2.040 1.980 -0.201
ENSG00000108669 E016 48.8511421 0.0005009385 1.556966e-02 4.177761e-02 17 78692494 78692495 2 - 1.732 1.645 -0.296
ENSG00000108669 E017 2.5494772 0.0069001568 5.788649e-01 7.038466e-01 17 78696007 78696009 3 - 0.586 0.523 -0.287
ENSG00000108669 E018 48.8146104 0.0005050684 1.124228e-02 3.174328e-02 17 78698268 78698268 1 - 1.735 1.642 -0.315
ENSG00000108669 E019 120.9082131 0.0006568456 2.711374e-04 1.262285e-03 17 78698269 78698380 112 - 2.122 2.036 -0.288
ENSG00000108669 E020 134.9097738 0.0049991933 1.570414e-04 7.785575e-04 17 78698820 78698968 149 - 2.196 2.065 -0.437
ENSG00000108669 E021 90.9075437 0.0003578342 4.350551e-07 3.893976e-06 17 78700331 78700391 61 - 2.037 1.886 -0.509
ENSG00000108669 E022 80.0346491 0.0003374038 6.042985e-03 1.872404e-02 17 78700392 78700443 52 - 1.935 1.862 -0.247
ENSG00000108669 E023 46.1671612 0.0004902955 3.627450e-02 8.410966e-02 17 78701671 78701671 1 - 1.698 1.624 -0.251
ENSG00000108669 E024 69.6433373 0.0003526572 4.780805e-04 2.076172e-03 17 78701672 78701751 80 - 1.897 1.784 -0.380
ENSG00000108669 E025 78.2257918 0.0003481651 1.429759e-02 3.890320e-02 17 78702122 78702240 119 - 1.918 1.856 -0.212
ENSG00000108669 E026 74.6024981 0.0026711265 2.114301e-02 5.390042e-02 17 78702538 78702604 67 - 1.901 1.826 -0.253
ENSG00000108669 E027 81.9610302 0.0034198102 4.408008e-03 1.428666e-02 17 78708197 78708261 65 - 1.959 1.858 -0.340
ENSG00000108669 E028 0.4847352 0.2366537554 3.767025e-01 5.210239e-01 17 78708912 78709350 439 - 0.259 0.101 -1.649
ENSG00000108669 E029 0.0000000       17 78709351 78709649 299 -      
ENSG00000108669 E030 74.8995698 0.0008405149 6.320731e-07 5.480040e-06 17 78709650 78709732 83 - 1.965 1.791 -0.585
ENSG00000108669 E031 0.0000000       17 78716929 78717025 97 -      
ENSG00000108669 E032 0.5138669 0.0206958026 3.051679e-01 4.472105e-01 17 78723213 78723395 183 - 0.259 0.100 -1.646
ENSG00000108669 E033 0.4741261 0.0211804689 3.050352e-01 4.470783e-01 17 78723396 78723750 355 - 0.259 0.100 -1.647
ENSG00000108669 E034 0.0000000       17 78723893 78724046 154 -      
ENSG00000108669 E035 0.4417591 0.0816246682 9.348234e-01 9.629683e-01 17 78727658 78727965 308 - 0.148 0.180 0.339
ENSG00000108669 E036 4.0286354 0.0072109895 9.753704e-02 1.867305e-01 17 78736692 78736967 276 - 0.799 0.587 -0.887
ENSG00000108669 E037 41.3676390 0.0016946195 8.215007e-06 5.565798e-05 17 78782202 78782297 96 - 1.735 1.518 -0.739