ENSG00000108651

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000484661 ENSG00000108651 HEK293_OSMI2_2hA HEK293_TMG_2hB UTP6 protein_coding retained_intron 36.59799 20.04747 51.65952 2.582544 1.263911 1.365174 4.342892 4.179191 2.800612 1.1682114 0.4843698 -0.5757876 0.1512125 0.2018667 0.05383333 -0.14803333 2.753728e-05 2.753728e-05   FALSE
MSTRG.14085.5 ENSG00000108651 HEK293_OSMI2_2hA HEK293_TMG_2hB UTP6 protein_coding   36.59799 20.04747 51.65952 2.582544 1.263911 1.365174 11.767310 5.494291 18.092766 0.4068719 0.8541845 1.7175815 0.3041792 0.2781000 0.35143333 0.07333333 2.533943e-01 2.753728e-05 TRUE TRUE
MSTRG.14085.6 ENSG00000108651 HEK293_OSMI2_2hA HEK293_TMG_2hB UTP6 protein_coding   36.59799 20.04747 51.65952 2.582544 1.263911 1.365174 14.391436 6.363696 22.714357 0.6485797 0.6939133 1.8340374 0.3702750 0.3195667 0.44043333 0.12086667 2.815956e-03 2.753728e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000108651 E001 82.9810573 0.0245561696 1.788808e-01 2.997358e-01 17 31860904 31863172 2269 - 1.846 1.996 0.504
ENSG00000108651 E002 5.5455457 0.0738720041 1.706840e-02 4.508900e-02 17 31863173 31863173 1 - 0.627 1.032 1.593
ENSG00000108651 E003 7.5070470 0.0452085415 5.186516e-03 1.643643e-02 17 31863174 31863213 40 - 0.737 1.143 1.536
ENSG00000108651 E004 11.0811757 0.0043243094 2.094387e-05 1.293144e-04 17 31863214 31863230 17 - 0.874 1.308 1.574
ENSG00000108651 E005 138.7096503 0.0002473443 4.940892e-11 9.189447e-10 17 31863231 31863348 118 - 2.045 2.251 0.689
ENSG00000108651 E006 279.8536214 0.0001704244 1.242764e-09 1.808141e-08 17 31863349 31863516 168 - 2.375 2.511 0.454
ENSG00000108651 E007 207.7252138 0.0011788370 1.452370e-03 5.481563e-03 17 31865366 31865438 73 - 2.261 2.358 0.326
ENSG00000108651 E008 7.4618382 0.0021745115 4.360326e-01 5.781633e-01 17 31866655 31866715 61 - 0.874 0.971 0.367
ENSG00000108651 E009 200.4576774 0.0012293917 3.002116e-02 7.199902e-02 17 31868046 31868112 67 - 2.256 2.324 0.226
ENSG00000108651 E010 0.0000000       17 31873184 31873377 194 -      
ENSG00000108651 E011 223.2819845 0.0010925355 8.202164e-03 2.429715e-02 17 31873378 31873487 110 - 2.299 2.378 0.263
ENSG00000108651 E012 170.6598147 0.0002462385 3.582965e-02 8.325446e-02 17 31873673 31873753 81 - 2.189 2.253 0.213
ENSG00000108651 E013 8.9801743 0.0023782148 3.794286e-09 5.052478e-08 17 31873754 31873948 195 - 0.667 1.308 2.405
ENSG00000108651 E014 260.4605578 0.0002210987 1.137184e-01 2.109451e-01 17 31875234 31875413 180 - 2.379 2.419 0.135
ENSG00000108651 E015 175.1903876 0.0003474045 4.668830e-01 6.064099e-01 17 31878250 31878327 78 - 2.214 2.239 0.082
ENSG00000108651 E016 187.7164744 0.0002373237 9.864135e-02 1.884219e-01 17 31878702 31878779 78 - 2.263 2.219 -0.146
ENSG00000108651 E017 117.8008469 0.0014947009 5.069694e-02 1.104015e-01 17 31878780 31878781 2 - 2.070 1.994 -0.256
ENSG00000108651 E018 12.8151031 0.0014003583 6.226877e-01 7.394339e-01 17 31880181 31880572 392 - 1.126 1.078 -0.171
ENSG00000108651 E019 299.4946126 0.0005318701 1.289410e-02 3.566748e-02 17 31880573 31880754 182 - 2.468 2.410 -0.194
ENSG00000108651 E020 170.3248796 0.0002605746 8.585197e-02 1.687479e-01 17 31884424 31884505 82 - 2.221 2.173 -0.163
ENSG00000108651 E021 0.4502799 0.0314712621 3.722337e-01 5.166839e-01 17 31884893 31885038 146 - 0.206 0.000 -10.492
ENSG00000108651 E022 136.9544676 0.0003780135 5.867432e-01 7.102411e-01 17 31885980 31886061 82 - 2.105 2.125 0.067
ENSG00000108651 E023 132.4985596 0.0065943951 9.784528e-01 9.906499e-01 17 31887236 31887313 78 - 2.099 2.090 -0.030
ENSG00000108651 E024 0.8450104 0.0225048558 5.646090e-01 6.918501e-01 17 31887314 31888221 908 - 0.206 0.311 0.786
ENSG00000108651 E025 147.4139165 0.0058196138 9.855936e-01 9.950214e-01 17 31889285 31889403 119 - 2.145 2.136 -0.030
ENSG00000108651 E026 0.1515154 0.0442202687 1.000000e+00   17 31892148 31892259 112 - 0.080 0.000 -8.907
ENSG00000108651 E027 152.2166331 0.0002270547 2.897653e-03 9.963044e-03 17 31892260 31892323 64 - 2.185 2.093 -0.309
ENSG00000108651 E028 131.7143554 0.0002447115 3.691471e-05 2.145406e-04 17 31892747 31892794 48 - 2.137 1.997 -0.471
ENSG00000108651 E029 166.6263491 0.0003460563 1.667252e-07 1.623186e-06 17 31894645 31894737 93 - 2.243 2.080 -0.547
ENSG00000108651 E030 115.8099892 0.0062364605 7.581733e-04 3.108752e-03 17 31894970 31895011 42 - 2.090 1.901 -0.634
ENSG00000108651 E031 157.3129744 0.0010405855 8.403702e-07 7.094724e-06 17 31899646 31899730 85 - 2.218 2.044 -0.583
ENSG00000108651 E032 1.0320003 0.0616826461 7.633273e-01 8.466677e-01 17 31901291 31901535 245 - 0.258 0.313 0.381
ENSG00000108651 E033 173.4353679 0.0002992337 1.782775e-12 4.192420e-11 17 31901536 31901749 214 - 2.273 2.052 -0.737