ENSG00000108604

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000323347 ENSG00000108604 HEK293_OSMI2_2hA HEK293_TMG_2hB SMARCD2 protein_coding protein_coding 104.5804 175.8701 63.95381 7.353336 1.517409 -1.459265 13.44245 7.230968 14.47825 2.590936 2.511351 1.000629 0.1754792 0.04016667 0.2260667 0.1859000 5.204989e-04 1.149266e-05 FALSE TRUE
ENST00000448276 ENSG00000108604 HEK293_OSMI2_2hA HEK293_TMG_2hB SMARCD2 protein_coding protein_coding 104.5804 175.8701 63.95381 7.353336 1.517409 -1.459265 81.85199 156.321038 42.93593 4.944596 2.307063 -1.864011 0.7316458 0.88976667 0.6721333 -0.2176333 1.149266e-05 1.149266e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000108604 E001 2009.9830695 3.049022e-03 3.606061e-09 4.819453e-08 17 63832081 63832501 421 - 3.069 3.231 0.539
ENSG00000108604 E002 1298.9514577 7.241874e-04 6.112226e-13 1.553243e-11 17 63832502 63832603 102 - 2.906 3.036 0.431
ENSG00000108604 E003 819.1324493 9.079661e-05 9.608295e-12 2.008676e-10 17 63832604 63832638 35 - 2.721 2.831 0.366
ENSG00000108604 E004 2164.1155797 8.016746e-05 1.343533e-10 2.322550e-09 17 63832639 63832991 353 - 3.182 3.246 0.211
ENSG00000108604 E005 1242.2760185 1.432080e-04 3.915971e-01 5.355178e-01 17 63833069 63833170 102 - 3.002 2.991 -0.037
ENSG00000108604 E006 1449.9735523 2.114004e-04 1.345159e-03 5.126975e-03 17 63833298 63833420 123 - 3.092 3.053 -0.133
ENSG00000108604 E007 1277.9088261 1.857376e-03 1.281088e-01 2.315314e-01 17 63833587 63833704 118 - 3.033 3.000 -0.110
ENSG00000108604 E008 577.7280860 1.409892e-03 2.352374e-01 3.686441e-01 17 63833705 63833722 18 - 2.685 2.656 -0.094
ENSG00000108604 E009 467.2461539 2.007380e-03 8.536808e-01 9.094631e-01 17 63833909 63833911 3 - 2.564 2.572 0.025
ENSG00000108604 E010 919.8551398 1.213425e-03 5.201539e-01 6.541617e-01 17 63833912 63834006 95 - 2.874 2.861 -0.042
ENSG00000108604 E011 455.7264324 1.943837e-03 4.806334e-01 6.188757e-01 17 63834167 63834177 11 - 2.574 2.555 -0.065
ENSG00000108604 E012 1104.7862485 7.253908e-04 1.052299e-01 1.984460e-01 17 63834178 63834328 151 - 2.964 2.937 -0.092
ENSG00000108604 E013 1.7296730 1.133627e-02 2.340135e-01 3.671575e-01 17 63834362 63834473 112 - 0.531 0.314 -1.172
ENSG00000108604 E014 840.0173038 5.236550e-04 2.528120e-02 6.245205e-02 17 63834474 63834575 102 - 2.855 2.815 -0.132
ENSG00000108604 E015 888.3253712 8.188905e-04 1.628259e-01 2.788262e-01 17 63834705 63834800 96 - 2.868 2.842 -0.087
ENSG00000108604 E016 12.8734882 1.338619e-03 1.792932e-03 6.577059e-03 17 63834801 63835145 345 - 1.278 0.969 -1.111
ENSG00000108604 E017 805.2252758 3.388088e-04 8.249422e-01 8.896994e-01 17 63835412 63835490 79 - 2.807 2.803 -0.013
ENSG00000108604 E018 824.7462712 1.406475e-03 2.384176e-02 5.948337e-02 17 63835491 63835567 77 - 2.856 2.805 -0.168
ENSG00000108604 E019 6.8011282 1.375902e-02 3.637549e-01 5.081877e-01 17 63835568 63835657 90 - 0.913 0.786 -0.490
ENSG00000108604 E020 9.4591988 1.493273e-02 8.130953e-05 4.341680e-04 17 63836746 63836921 176 - 1.264 0.798 -1.716
ENSG00000108604 E021 997.4519287 2.210540e-03 8.792162e-04 3.541106e-03 17 63836922 63837044 123 - 2.964 2.881 -0.277
ENSG00000108604 E022 1.7555850 2.752381e-02 5.918523e-03 1.839438e-02 17 63837146 63837194 49 - 0.715 0.233 -2.564
ENSG00000108604 E023 584.6133850 1.468581e-03 1.456729e-04 7.285260e-04 17 63837195 63837237 43 - 2.739 2.645 -0.311
ENSG00000108604 E024 690.0414022 2.963993e-03 9.909070e-06 6.592834e-05 17 63837441 63837625 185 - 2.839 2.709 -0.433
ENSG00000108604 E025 5.2119570 2.432241e-02 6.413779e-01 7.544261e-01 17 63838610 63838728 119 - 0.763 0.690 -0.297
ENSG00000108604 E026 6.7970220 2.744009e-03 6.862936e-01 7.888523e-01 17 63842381 63842458 78 - 0.844 0.788 -0.222
ENSG00000108604 E027 111.3601104 4.299998e-03 2.785050e-06 2.099978e-05 17 63842459 63842465 7 - 2.121 1.893 -0.763
ENSG00000108604 E028 256.8929747 5.492247e-03 1.119681e-06 9.200614e-06 17 63842466 63842868 403 - 2.469 2.260 -0.696
ENSG00000108604 E029 0.8751107 2.902604e-01 3.446141e-01 4.887014e-01 17 63843020 63843272 253 - 0.001 0.275 9.535
ENSG00000108604 E030 2.9422171 8.773894e-02 5.153481e-01 6.500336e-01 17 63843273 63843433 161 - 0.601 0.478 -0.579