ENSG00000108599

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000225737 ENSG00000108599 HEK293_OSMI2_2hA HEK293_TMG_2hB AKAP10 protein_coding protein_coding 7.19798 2.62613 10.67221 0.1883874 0.3377459 2.018717 4.4435429 2.38415089 5.8187483 0.20509224 0.2149536 1.283672 0.69125833 0.90626667 0.54503333 -0.36123333 4.732194e-16 4.732194e-16 FALSE TRUE
ENST00000583951 ENSG00000108599 HEK293_OSMI2_2hA HEK293_TMG_2hB AKAP10 protein_coding protein_coding 7.19798 2.62613 10.67221 0.1883874 0.3377459 2.018717 0.2690601 0.00000000 0.5663392 0.00000000 0.2843581 5.848846 0.03178333 0.00000000 0.05326667 0.05326667 4.143549e-01 4.732194e-16   FALSE
MSTRG.13872.3 ENSG00000108599 HEK293_OSMI2_2hA HEK293_TMG_2hB AKAP10 protein_coding   7.19798 2.62613 10.67221 0.1883874 0.3377459 2.018717 1.0297142 0.03885646 2.2758622 0.03885646 0.5944997 5.548045 0.09446667 0.01653333 0.21586667 0.19933333 6.112454e-03 4.732194e-16 TRUE TRUE
MSTRG.13872.4 ENSG00000108599 HEK293_OSMI2_2hA HEK293_TMG_2hB AKAP10 protein_coding   7.19798 2.62613 10.67221 0.1883874 0.3377459 2.018717 0.7087612 0.07536213 1.1946174 0.03811804 0.5554715 3.818835 0.09899167 0.02833333 0.11120000 0.08286667 3.083749e-01 4.732194e-16 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000108599 E001 22.4768076 0.0133714264 1.272876e-03 4.886670e-03 17 19904302 19904907 606 - 1.227 1.529 1.049
ENSG00000108599 E002 17.3141564 0.0367442471 3.734714e-01 5.179170e-01 17 19904908 19905060 153 - 1.191 1.317 0.444
ENSG00000108599 E003 38.3800967 0.0408752266 4.773607e-02 1.051497e-01 17 19905061 19905230 170 - 1.461 1.737 0.939
ENSG00000108599 E004 151.1203937 0.0015925688 6.818960e-15 2.306842e-13 17 19905231 19905996 766 - 2.048 2.311 0.880
ENSG00000108599 E005 65.0325624 0.0004343090 6.937003e-03 2.105946e-02 17 19905997 19906167 171 - 1.736 1.872 0.459
ENSG00000108599 E006 38.0067542 0.0006597728 1.899998e-01 3.137657e-01 17 19906168 19906226 59 - 1.525 1.617 0.314
ENSG00000108599 E007 24.7011690 0.0024380690 3.360283e-01 4.798484e-01 17 19906227 19906232 6 - 1.349 1.436 0.302
ENSG00000108599 E008 43.4133504 0.0004837793 9.455873e-02 1.822256e-01 17 19909181 19909238 58 - 1.576 1.682 0.363
ENSG00000108599 E009 32.2971572 0.0006846623 1.776037e-01 2.981232e-01 17 19909239 19909276 38 - 1.453 1.553 0.344
ENSG00000108599 E010 32.3786080 0.0052398933 2.022842e-02 5.196362e-02 17 19909926 19909978 53 - 1.423 1.599 0.602
ENSG00000108599 E011 42.0189042 0.0007234293 7.573624e-01 8.422177e-01 17 19920036 19920118 83 - 1.593 1.586 -0.021
ENSG00000108599 E012 39.1432033 0.0007141792 2.127409e-01 3.417662e-01 17 19924408 19924512 105 - 1.578 1.511 -0.229
ENSG00000108599 E013 14.5652940 0.0012773907 2.886478e-01 4.292603e-01 17 19924513 19924517 5 - 1.181 1.087 -0.336
ENSG00000108599 E014 36.5893107 0.0009122251 6.773183e-01 7.820640e-01 17 19931805 19931978 174 - 1.522 1.560 0.130
ENSG00000108599 E015 0.4783925 0.0222400012 7.578065e-01 8.425078e-01 17 19936002 19936285 284 - 0.139 0.193 0.571
ENSG00000108599 E016 41.0103562 0.0005535564 3.827377e-01 5.269098e-01 17 19936286 19936430 145 - 1.565 1.628 0.218
ENSG00000108599 E017 48.0080533 0.0004977207 8.090854e-01 8.787309e-01 17 19939713 19939849 137 - 1.646 1.672 0.088
ENSG00000108599 E018 19.6642644 0.0052789122 6.524234e-01 7.631351e-01 17 19940887 19940897 11 - 1.268 1.324 0.195
ENSG00000108599 E019 37.6546293 0.0007419936 8.264118e-01 8.907641e-01 17 19940898 19941010 113 - 1.546 1.573 0.092
ENSG00000108599 E020 37.9442890 0.0025155499 4.210014e-01 5.641592e-01 17 19941826 19941910 85 - 1.565 1.525 -0.137
ENSG00000108599 E021 0.0000000       17 19947141 19947406 266 -      
ENSG00000108599 E022 38.4638644 0.0011345159 1.302621e-02 3.597341e-02 17 19947407 19947505 99 - 1.597 1.446 -0.518
ENSG00000108599 E023 70.3443208 0.0004693297 5.987353e-06 4.189422e-05 17 19958014 19958334 321 - 1.864 1.651 -0.722
ENSG00000108599 E024 46.4033971 0.0047971049 9.756925e-06 6.503941e-05 17 19958335 19958424 90 - 1.703 1.391 -1.067
ENSG00000108599 E025 30.8146841 0.0006310953 9.347449e-07 7.804179e-06 17 19958425 19958443 19 - 1.542 1.160 -1.328
ENSG00000108599 E026 48.6208044 0.0006232995 3.893756e-07 3.518197e-06 17 19958444 19958567 124 - 1.724 1.419 -1.041
ENSG00000108599 E027 20.2815744 0.0198863723 2.638636e-04 1.232343e-03 17 19958568 19958571 4 - 1.380 0.945 -1.559
ENSG00000108599 E028 24.5736029 0.0060436871 4.912232e-04 2.127103e-03 17 19962840 19962859 20 - 1.441 1.124 -1.111
ENSG00000108599 E029 36.6634510 0.0005502485 4.130628e-04 1.824474e-03 17 19962860 19962966 107 - 1.591 1.359 -0.795
ENSG00000108599 E030 18.4783886 0.0021168959 5.300720e-02 1.144981e-01 17 19962967 19962991 25 - 1.294 1.125 -0.600
ENSG00000108599 E031 16.9712420 0.0011872429 1.289420e-01 2.326933e-01 17 19962992 19963022 31 - 1.255 1.125 -0.463
ENSG00000108599 E032 0.7385489 0.0601430654 1.953529e-01 3.203994e-01 17 19967919 19968034 116 - 0.289 0.000 -9.913
ENSG00000108599 E033 19.8503297 0.0198313871 1.904832e-01 3.143640e-01 17 19968414 19968461 48 - 1.318 1.189 -0.456
ENSG00000108599 E034 19.1227046 0.0011007821 1.340815e-01 2.398253e-01 17 19977592 19977828 237 - 1.298 1.177 -0.430
ENSG00000108599 E035 0.0000000       17 19978234 19978343 110 -