ENSG00000108591

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000225729 ENSG00000108591 HEK293_OSMI2_2hA HEK293_TMG_2hB DRG2 protein_coding protein_coding 63.41057 104.026 39.82722 6.075836 0.5905162 -1.384895 38.044955 71.600202 22.221976 3.9574690 0.9413135 -1.6875290 0.57090000 0.6887333 0.55750000 -0.13123333 2.033123e-05 3.641435e-07 FALSE TRUE
ENST00000578173 ENSG00000108591 HEK293_OSMI2_2hA HEK293_TMG_2hB DRG2 protein_coding retained_intron 63.41057 104.026 39.82722 6.075836 0.5905162 -1.384895 4.538139 4.323732 3.328556 2.3895569 0.6690818 -0.3763858 0.07726250 0.0397000 0.08380000 0.04410000 3.016685e-01 3.641435e-07 FALSE TRUE
ENST00000582314 ENSG00000108591 HEK293_OSMI2_2hA HEK293_TMG_2hB DRG2 protein_coding nonsense_mediated_decay 63.41057 104.026 39.82722 6.075836 0.5905162 -1.384895 4.337129 3.975055 3.550167 0.2444346 0.3345657 -0.1626547 0.08077083 0.0382000 0.08913333 0.05093333 3.641435e-07 3.641435e-07 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000108591 E001 4.169564 0.0038564322 3.744402e-01 5.188494e-01 17 18087892 18087908 17 + 0.734 0.610 -0.523
ENSG00000108591 E002 5.902358 0.0032810249 3.512885e-01 4.955143e-01 17 18087909 18087920 12 + 0.849 0.734 -0.459
ENSG00000108591 E003 8.189704 0.0020698451 1.177249e-01 2.166903e-01 17 18087921 18087924 4 + 1.016 0.842 -0.657
ENSG00000108591 E004 9.662229 0.0018026317 1.707938e-01 2.891983e-01 17 18087925 18087926 2 + 1.060 0.919 -0.524
ENSG00000108591 E005 17.424539 0.0011021909 3.856640e-01 5.298482e-01 17 18087927 18087940 14 + 1.231 1.165 -0.231
ENSG00000108591 E006 50.050036 0.0060966546 1.522928e-02 4.100618e-02 17 18087941 18087947 7 + 1.732 1.589 -0.485
ENSG00000108591 E007 50.050036 0.0060966546 1.522928e-02 4.100618e-02 17 18087948 18087948 1 + 1.732 1.589 -0.485
ENSG00000108591 E008 68.420478 0.0003669612 1.899221e-04 9.208686e-04 17 18087949 18087960 12 + 1.878 1.718 -0.539
ENSG00000108591 E009 72.276506 0.0003470551 1.877898e-05 1.172082e-04 17 18087961 18087961 1 + 1.914 1.735 -0.604
ENSG00000108591 E010 87.977550 0.0003271208 3.687701e-04 1.653352e-03 17 18087962 18087964 3 + 1.967 1.833 -0.451
ENSG00000108591 E011 88.832024 0.0003382887 3.034225e-04 1.393312e-03 17 18087965 18087965 1 + 1.972 1.836 -0.456
ENSG00000108591 E012 95.146989 0.0003410962 4.467301e-06 3.216956e-05 17 18087966 18087967 2 + 2.025 1.856 -0.565
ENSG00000108591 E013 173.057411 0.0002927277 9.559663e-02 1.837845e-01 17 18087968 18087971 4 + 2.186 2.149 -0.123
ENSG00000108591 E014 176.959445 0.0005052428 1.019456e-01 1.934676e-01 17 18087972 18087973 2 + 2.195 2.158 -0.122
ENSG00000108591 E015 180.133833 0.0009564332 6.916475e-02 1.419893e-01 17 18087974 18087975 2 + 2.208 2.164 -0.147
ENSG00000108591 E016 198.729520 0.0011871443 3.631058e-02 8.417271e-02 17 18087976 18087978 3 + 2.257 2.206 -0.173
ENSG00000108591 E017 281.069830 0.0018282412 2.560334e-01 3.929970e-01 17 18087979 18088006 28 + 2.382 2.364 -0.061
ENSG00000108591 E018 414.041879 0.0029815390 2.635910e-01 4.015126e-01 17 18088007 18088087 81 + 2.550 2.533 -0.057
ENSG00000108591 E019 2.809819 0.4146150675 3.952702e-01 5.390855e-01 17 18091918 18092074 157 + 0.636 0.464 -0.799
ENSG00000108591 E020 587.364518 0.0023734845 9.216380e-01 9.545470e-01 17 18093813 18093968 156 + 2.676 2.693 0.056
ENSG00000108591 E021 217.954714 0.0001880757 8.699208e-01 9.203167e-01 17 18093969 18093973 5 + 2.251 2.262 0.037
ENSG00000108591 E022 13.308756 0.0077269536 1.092510e-03 4.278682e-03 17 18093974 18094280 307 + 1.296 0.977 -1.145
ENSG00000108591 E023 2.948666 0.0055575111 3.728502e-05 2.165068e-04 17 18095421 18095489 69 + 0.912 0.292 -2.900
ENSG00000108591 E024 70.924356 0.0163842325 3.847858e-05 2.227140e-04 17 18095722 18098269 2548 + 1.982 1.693 -0.975
ENSG00000108591 E025 414.411232 0.0019102594 4.932065e-01 6.302375e-01 17 18098270 18098359 90 + 2.507 2.546 0.127
ENSG00000108591 E026 4.606142 0.0046132016 5.561174e-03 1.744978e-02 17 18098360 18098482 123 + 0.941 0.567 -1.523
ENSG00000108591 E027 314.795234 0.0019397841 8.094457e-01 8.789912e-01 17 18099017 18099077 61 + 2.397 2.423 0.086
ENSG00000108591 E028 14.422728 0.0024167374 6.910385e-03 2.099253e-02 17 18099078 18099093 16 + 1.284 1.041 -0.866
ENSG00000108591 E029 49.121961 0.0105828319 1.828192e-05 1.144301e-04 17 18099094 18099632 539 + 1.824 1.535 -0.981
ENSG00000108591 E030 340.962995 0.0007798409 8.377469e-01 8.985780e-01 17 18099633 18099715 83 + 2.434 2.456 0.074
ENSG00000108591 E031 209.388668 0.0001919063 8.269622e-01 8.911627e-01 17 18099716 18099723 8 + 2.234 2.244 0.032
ENSG00000108591 E032 89.200649 0.0003143122 1.489397e-11 3.016061e-10 17 18099724 18100129 406 + 2.057 1.802 -0.858
ENSG00000108591 E033 74.515246 0.0031696897 2.271560e-09 3.151983e-08 17 18100130 18100362 233 + 2.004 1.720 -0.955
ENSG00000108591 E034 401.602163 0.0001439709 5.414168e-01 6.724080e-01 17 18100363 18100435 73 + 2.521 2.524 0.011
ENSG00000108591 E035 467.507569 0.0001492298 6.717663e-01 7.779259e-01 17 18100569 18100659 91 + 2.582 2.590 0.026
ENSG00000108591 E036 211.401902 0.0005690365 4.063350e-01 5.499938e-01 17 18101493 18101494 2 + 2.214 2.256 0.140
ENSG00000108591 E037 421.305425 0.0002394972 1.223304e-01 2.232671e-01 17 18101495 18101590 96 + 2.504 2.554 0.164
ENSG00000108591 E038 459.073404 0.0001714152 2.631492e-02 6.457937e-02 17 18101921 18101997 77 + 2.532 2.593 0.204
ENSG00000108591 E039 473.229363 0.0001406748 8.725688e-02 1.709786e-01 17 18103801 18103889 89 + 2.554 2.604 0.166
ENSG00000108591 E040 8.763623 0.0083099985 2.898668e-02 6.997897e-02 17 18104560 18104622 63 + 1.100 0.853 -0.917
ENSG00000108591 E041 474.322622 0.0010455100 1.048491e-01 1.978658e-01 17 18104623 18104681 59 + 2.552 2.609 0.190
ENSG00000108591 E042 49.822725 0.0020885216 2.321653e-03 8.218669e-03 17 18105447 18106432 986 + 1.745 1.585 -0.545
ENSG00000108591 E043 422.862926 0.0013567799 1.495016e-02 4.037322e-02 17 18106433 18106470 38 + 2.481 2.565 0.278
ENSG00000108591 E044 346.663859 0.0014601773 3.676409e-02 8.501907e-02 17 18106471 18106486 16 + 2.400 2.478 0.261
ENSG00000108591 E045 1420.540118 0.0030960018 1.253017e-07 1.249107e-06 17 18107154 18107970 817 + 2.944 3.104 0.532