ENSG00000108590

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000225728 ENSG00000108590 HEK293_OSMI2_2hA HEK293_TMG_2hB MED31 protein_coding protein_coding 19.33725 15.41339 23.35984 2.852445 0.4568855 0.5995285 3.819920 1.8801129 5.7775873 0.4477766 0.3060427 1.6144896 0.18719583 0.11976667 0.24713333 0.12736667 7.874719e-07 7.874719e-07 FALSE TRUE
ENST00000574128 ENSG00000108590 HEK293_OSMI2_2hA HEK293_TMG_2hB MED31 protein_coding protein_coding 19.33725 15.41339 23.35984 2.852445 0.4568855 0.5995285 6.526506 4.9340186 7.9394015 0.9716877 0.3220095 0.6851621 0.32646667 0.32043333 0.33976667 0.01933333 8.255908e-01 7.874719e-07   FALSE
ENST00000575197 ENSG00000108590 HEK293_OSMI2_2hA HEK293_TMG_2hB MED31 protein_coding protein_coding 19.33725 15.41339 23.35984 2.852445 0.4568855 0.5995285 7.797389 7.8153655 8.7097523 1.5555466 0.1172421 0.1561290 0.41603333 0.50473333 0.37300000 -0.13173333 1.932371e-05 7.874719e-07   FALSE
ENST00000575519 ENSG00000108590 HEK293_OSMI2_2hA HEK293_TMG_2hB MED31 protein_coding retained_intron 19.33725 15.41339 23.35984 2.852445 0.4568855 0.5995285 1.193430 0.7838906 0.9331037 0.3102590 0.1579066 0.2484761 0.07028333 0.05503333 0.04006667 -0.01496667 9.128527e-01 7.874719e-07   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000108590 E001 22.062399 0.0009288347 5.920590e-06 4.146077e-05 17 6643311 6644278 968 - 1.488 1.139 -1.221
ENSG00000108590 E002 6.043549 0.0300239958 7.898512e-01 8.655678e-01 17 6644279 6644294 16 - 0.836 0.886 0.194
ENSG00000108590 E003 220.754583 0.0003092309 1.544763e-02 4.150778e-02 17 6644295 6644659 365 - 2.329 2.379 0.168
ENSG00000108590 E004 2.183075 0.0354509134 8.561339e-01 9.110600e-01 17 6649889 6649981 93 - 0.495 0.529 0.164
ENSG00000108590 E005 143.761730 0.0002764220 1.892330e-02 4.916429e-02 17 6649982 6650078 97 - 2.193 2.131 -0.206
ENSG00000108590 E006 9.725033 0.0831057512 4.006687e-01 5.443321e-01 17 6650079 6650355 277 - 0.966 1.098 0.485
ENSG00000108590 E007 147.042172 0.0002603493 7.358500e-01 8.265126e-01 17 6650356 6650433 78 - 2.171 2.181 0.034
ENSG00000108590 E008 3.589998 0.0065973937 9.317404e-01 9.609979e-01 17 6651349 6651500 152 - 0.649 0.662 0.057
ENSG00000108590 E009 118.428112 0.0002906336 5.453482e-01 6.757136e-01 17 6651501 6651634 134 - 2.074 2.094 0.066