ENSG00000108587

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000225724 ENSG00000108587 HEK293_OSMI2_2hA HEK293_TMG_2hB GOSR1 protein_coding protein_coding 13.0863 8.524791 21.51722 0.5548687 0.9501115 1.334735 4.222497 2.4943521 5.998497 0.2311189 0.1384220 1.2625668 0.3303042 0.29526667 0.2797000 -0.01556667 9.168265e-01 3.941571e-16 FALSE TRUE
ENST00000451249 ENSG00000108587 HEK293_OSMI2_2hA HEK293_TMG_2hB GOSR1 protein_coding protein_coding 13.0863 8.524791 21.51722 0.5548687 0.9501115 1.334735 3.340296 4.6157973 3.284200 0.4901981 0.3600609 -0.4897738 0.3257167 0.53956667 0.1522000 -0.38736667 3.941571e-16 3.941571e-16 FALSE TRUE
ENST00000467635 ENSG00000108587 HEK293_OSMI2_2hA HEK293_TMG_2hB GOSR1 protein_coding retained_intron 13.0863 8.524791 21.51722 0.5548687 0.9501115 1.334735 4.448459 0.4882131 10.300300 0.4882131 0.8556054 4.3711796 0.2570542 0.05093333 0.4770667 0.42613333 2.806506e-02 3.941571e-16 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000108587 E001 1.7015498 0.0080742965 1.094955e-01 2.048244e-01 17 30477362 30477407 46 + 0.536 0.251 -1.635
ENSG00000108587 E002 3.6870136 0.0041954515 1.055294e-01 1.989137e-01 17 30477408 30477416 9 + 0.768 0.525 -1.051
ENSG00000108587 E003 5.1135446 0.0083618185 1.155968e-01 2.136950e-01 17 30477417 30477419 3 + 0.874 0.656 -0.881
ENSG00000108587 E004 9.3393061 0.0619596599 2.492343e-02 6.171632e-02 17 30477420 30477422 3 + 1.145 0.784 -1.352
ENSG00000108587 E005 18.8899397 0.0189638907 1.758594e-03 6.467376e-03 17 30477423 30477426 4 + 1.421 1.090 -1.166
ENSG00000108587 E006 42.3645109 0.0058195930 1.495448e-03 5.621081e-03 17 30477427 30477441 15 + 1.721 1.514 -0.706
ENSG00000108587 E007 59.2081817 0.0004320083 5.174573e-04 2.225139e-03 17 30477442 30477464 23 + 1.845 1.685 -0.541
ENSG00000108587 E008 4.8087900 0.0560176003 2.507932e-01 3.868761e-01 17 30477465 30477486 22 + 0.842 0.653 -0.764
ENSG00000108587 E009 2.1454870 0.0066714144 3.162442e-02 7.512322e-02 17 30477487 30477501 15 + 0.628 0.251 -2.050
ENSG00000108587 E010 0.9556140 0.2636766710 3.532297e-01 4.974599e-01 17 30478495 30480173 1679 + 0.371 0.146 -1.758
ENSG00000108587 E011 1.2994549 0.0171751372 6.160440e-01 7.341861e-01 17 30480856 30481142 287 + 0.318 0.409 0.533
ENSG00000108587 E012 111.6932345 0.0002911600 1.745994e-05 1.097493e-04 17 30481143 30481257 115 + 2.112 1.969 -0.481
ENSG00000108587 E013 25.3489788 0.0008044595 1.108666e-01 2.068235e-01 17 30481258 30481263 6 + 1.468 1.360 -0.373
ENSG00000108587 E014 0.1515154 0.0425899576 6.850421e-01   17 30481264 30481342 79 + 0.104 0.000 -10.329
ENSG00000108587 E015 0.6664265 0.0177016098 7.186595e-01 8.136815e-01 17 30482900 30483056 157 + 0.188 0.251 0.535
ENSG00000108587 E016 124.5750553 0.0002868605 1.312229e-05 8.478203e-05 17 30484214 30484301 88 + 2.155 2.017 -0.463
ENSG00000108587 E017 142.1807034 0.0002345303 4.507348e-05 2.567436e-04 17 30484663 30484770 108 + 2.205 2.085 -0.401
ENSG00000108587 E018 0.1515154 0.0425899576 6.850421e-01   17 30484771 30485134 364 + 0.104 0.000 -10.329
ENSG00000108587 E019 125.4869713 0.0002641381 3.959139e-05 2.284291e-04 17 30490126 30490217 92 + 2.154 2.025 -0.433
ENSG00000108587 E020 0.5848540 0.0619964750 4.429244e-02 9.891747e-02 17 30490218 30490350 133 + 0.000 0.339 11.495
ENSG00000108587 E021 75.4688940 0.0004407372 2.036367e-02 5.225154e-02 17 30492679 30492690 12 + 1.923 1.830 -0.314
ENSG00000108587 E022 134.6178030 0.0002540303 3.161844e-01 4.589455e-01 17 30492691 30492753 63 + 2.145 2.117 -0.094
ENSG00000108587 E023 0.0000000       17 30495426 30495582 157 +      
ENSG00000108587 E024 0.3686942 0.0260071368 7.871360e-01 8.636707e-01 17 30510593 30510879 287 + 0.104 0.144 0.537
ENSG00000108587 E025 100.2959316 0.0003031209 6.080886e-01 7.279334e-01 17 30510880 30510909 30 + 2.013 1.997 -0.053
ENSG00000108587 E026 1.0499988 0.1664289192 3.176045e-02 7.538774e-02 17 30519699 30519938 240 + 0.462 0.000 -12.692
ENSG00000108587 E027 135.3716684 0.0002306523 3.815189e-01 5.258083e-01 17 30519939 30520021 83 + 2.120 2.149 0.095
ENSG00000108587 E028 3.1345241 0.0049286091 1.401530e-01 2.482290e-01 17 30520022 30520432 411 + 0.704 0.471 -1.050
ENSG00000108587 E029 1163.3111293 0.0001103824 1.161926e-36 3.213479e-34 17 30522254 30527592 5339 + 3.018 3.117 0.329