ENSG00000108582

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000225719 ENSG00000108582 HEK293_OSMI2_2hA HEK293_TMG_2hB CPD protein_coding protein_coding 12.33833 4.04822 18.37047 0.4875141 0.643783 2.179255 5.5725615 1.6777588 8.3737427 0.1631955 0.4173518 2.3124857 0.48215000 0.43970000 0.45590000 0.0162000 9.495785e-01 4.610059e-34 FALSE TRUE
ENST00000543464 ENSG00000108582 HEK293_OSMI2_2hA HEK293_TMG_2hB CPD protein_coding protein_coding 12.33833 4.04822 18.37047 0.4875141 0.643783 2.179255 2.8842100 0.0000000 5.0604700 0.0000000 1.0107752 8.9859757 0.14193750 0.00000000 0.27396667 0.2739667 9.586151e-12 4.610059e-34 FALSE TRUE
ENST00000579502 ENSG00000108582 HEK293_OSMI2_2hA HEK293_TMG_2hB CPD protein_coding nonsense_mediated_decay 12.33833 4.04822 18.37047 0.4875141 0.643783 2.179255 0.6174897 1.2957283 0.0000000 0.1828427 0.0000000 -7.0287110 0.14945000 0.32206667 0.00000000 -0.3220667 4.610059e-34 4.610059e-34   FALSE
ENST00000584051 ENSG00000108582 HEK293_OSMI2_2hA HEK293_TMG_2hB CPD protein_coding processed_transcript 12.33833 4.04822 18.37047 0.4875141 0.643783 2.179255 0.7000641 0.3866177 0.7328711 0.3866177 0.7328711 0.9053626 0.05754167 0.08706667 0.03806667 -0.0490000 8.665936e-01 4.610059e-34 FALSE FALSE
ENST00000584221 ENSG00000108582 HEK293_OSMI2_2hA HEK293_TMG_2hB CPD protein_coding protein_coding 12.33833 4.04822 18.37047 0.4875141 0.643783 2.179255 0.1462774 0.6551413 0.0000000 0.4106680 0.0000000 -6.0555889 0.03210000 0.14330000 0.00000000 -0.1433000 3.471383e-02 4.610059e-34 FALSE FALSE
MSTRG.14021.2 ENSG00000108582 HEK293_OSMI2_2hA HEK293_TMG_2hB CPD protein_coding   12.33833 4.04822 18.37047 0.4875141 0.643783 2.179255 2.2157457 0.0000000 3.7545827 0.0000000 0.8049878 8.5563462 0.12145417 0.00000000 0.20663333 0.2066333 4.543713e-08 4.610059e-34 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000108582 E001 56.5631036 0.0614738138 3.118467e-04 1.427912e-03 17 30378927 30379615 689 + 1.653 1.201 -1.561
ENSG00000108582 E002 26.1928103 0.0131383899 5.886942e-03 1.831423e-02 17 30379616 30379726 111 + 1.316 1.060 -0.911
ENSG00000108582 E003 0.0000000       17 30380236 30380642 407 +      
ENSG00000108582 E004 80.3053076 0.0021481417 1.969162e-08 2.299241e-07 17 30384989 30385236 248 + 1.791 1.486 -1.035
ENSG00000108582 E005 0.3030308 0.2921877308 1.000000e+00   17 30385237 30385292 56 + 0.095 0.000 -8.761
ENSG00000108582 E006 77.3069522 0.0004948581 1.071660e-07 1.082731e-06 17 30420841 30420983 143 + 1.771 1.510 -0.888
ENSG00000108582 E007 71.0794670 0.0003399477 1.613923e-08 1.914306e-07 17 30421664 30421833 170 + 1.740 1.434 -1.045
ENSG00000108582 E008 113.7527827 0.0003147524 2.022051e-08 2.355623e-07 17 30422674 30423023 350 + 1.932 1.727 -0.694
ENSG00000108582 E009 91.0350398 0.0259684913 1.269159e-02 3.518628e-02 17 30423506 30423697 192 + 1.832 1.675 -0.534
ENSG00000108582 E010 84.1120031 0.0007383017 6.855407e-04 2.846483e-03 17 30427391 30427558 168 + 1.793 1.682 -0.377
ENSG00000108582 E011 60.9141375 0.0004112496 5.001770e-03 1.593439e-02 17 30431772 30431881 110 + 1.655 1.555 -0.344
ENSG00000108582 E012 32.5946180 0.0013290249 2.057865e-02 5.270608e-02 17 30438975 30438984 10 + 1.395 1.266 -0.451
ENSG00000108582 E013 55.7405137 0.0005070845 5.034283e-03 1.602452e-02 17 30438985 30439077 93 + 1.620 1.510 -0.376
ENSG00000108582 E014 75.5052306 0.0093519387 2.093752e-02 5.345466e-02 17 30442308 30442450 143 + 1.746 1.656 -0.306
ENSG00000108582 E015 75.5487683 0.0013852343 7.483795e-03 2.247060e-02 17 30443802 30443971 170 + 1.744 1.666 -0.265
ENSG00000108582 E016 0.2944980 0.4067031368 1.000000e+00   17 30443972 30444144 173 + 0.094 0.000 -8.613
ENSG00000108582 E017 109.4825409 0.0002645541 4.213940e-05 2.416145e-04 17 30445691 30446020 330 + 1.906 1.786 -0.404
ENSG00000108582 E018 0.0000000       17 30447562 30447564 3 +      
ENSG00000108582 E019 83.0679593 0.0003874247 4.377127e-06 3.156219e-05 17 30449553 30449672 120 + 1.796 1.604 -0.649
ENSG00000108582 E020 60.3184413 0.0007957323 3.458448e-02 8.086702e-02 17 30449673 30449748 76 + 1.647 1.595 -0.179
ENSG00000108582 E021 0.9493850 0.2670428235 8.111602e-01 8.801972e-01 17 30450236 30450294 59 + 0.205 0.276 0.554
ENSG00000108582 E022 56.4807721 0.0071311665 1.061765e-01 1.998829e-01 17 30451711 30451756 46 + 1.616 1.575 -0.140
ENSG00000108582 E023 66.1155887 0.0060495430 9.778214e-02 1.871222e-01 17 30451757 30451809 53 + 1.682 1.649 -0.114
ENSG00000108582 E024 58.4350653 0.0004380270 2.909051e-01 4.317157e-01 17 30451810 30451846 37 + 1.621 1.641 0.065
ENSG00000108582 E025 0.9567573 0.4446323020 1.113111e-01 2.074730e-01 17 30454021 30455338 1318 + 0.094 0.580 3.532
ENSG00000108582 E026 87.4324378 0.0003131867 1.555637e-01 2.691471e-01 17 30455339 30455470 132 + 1.792 1.805 0.041
ENSG00000108582 E027 0.1451727 0.0427430726 1.000000e+00   17 30455471 30456255 785 + 0.050 0.000 -8.639
ENSG00000108582 E028 66.1116829 0.0004922800 2.044090e-01 3.316775e-01 17 30456256 30456324 69 + 1.673 1.682 0.032
ENSG00000108582 E029 49.9303804 0.0125545478 5.515745e-01 6.810095e-01 17 30456325 30456351 27 + 1.549 1.579 0.103
ENSG00000108582 E030 57.3886074 0.0085364855 3.831664e-01 5.273462e-01 17 30456462 30456526 65 + 1.612 1.625 0.043
ENSG00000108582 E031 0.0000000       17 30456527 30456863 337 +      
ENSG00000108582 E032 74.1849293 0.0044083760 7.075867e-01 8.054667e-01 17 30461180 30461311 132 + 1.715 1.774 0.201
ENSG00000108582 E033 38.2632543 0.0005753358 2.260372e-01 3.576373e-01 17 30461877 30461885 9 + 1.445 1.434 -0.038
ENSG00000108582 E034 91.8183741 0.0002856443 1.200177e-01 2.200127e-01 17 30461886 30462062 177 + 1.815 1.822 0.024
ENSG00000108582 E035 40.1077857 0.0008989504 1.718605e-01 2.906363e-01 17 30462370 30462395 26 + 1.469 1.447 -0.074
ENSG00000108582 E036 58.1102440 0.0004094409 2.491095e-02 6.168785e-02 17 30462396 30462469 74 + 1.629 1.565 -0.218
ENSG00000108582 E037 488.2991732 0.0001464168 1.392061e-10 2.398561e-09 17 30464588 30466246 1659 + 2.500 2.711 0.702
ENSG00000108582 E038 492.0703672 0.0184306213 7.237661e-11 1.307354e-09 17 30466247 30469989 3743 + 2.438 2.892 1.510