ENSG00000108559

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000574087 ENSG00000108559 HEK293_OSMI2_2hA HEK293_TMG_2hB NUP88 protein_coding retained_intron 55.21346 39.65294 76.27686 6.913958 3.295627 0.9436429 4.265479 6.116999 2.254586 1.4715610 1.391577 -1.4359332 0.0941375 0.1547667 0.02823333 -0.12653333 0.29903971 0.03374277 FALSE  
ENST00000574855 ENSG00000108559 HEK293_OSMI2_2hA HEK293_TMG_2hB NUP88 protein_coding retained_intron 55.21346 39.65294 76.27686 6.913958 3.295627 0.9436429 18.304018 15.781575 23.563741 3.6715871 2.603228 0.5780256 0.3378583 0.3905667 0.30803333 -0.08253333 0.24750188 0.03374277 FALSE  
MSTRG.13507.11 ENSG00000108559 HEK293_OSMI2_2hA HEK293_TMG_2hB NUP88 protein_coding   55.21346 39.65294 76.27686 6.913958 3.295627 0.9436429 16.554639 9.217367 26.007490 1.2133995 1.911214 1.4954908 0.2811833 0.2396000 0.34423333 0.10463333 0.27803901 0.03374277 FALSE  
MSTRG.13507.5 ENSG00000108559 HEK293_OSMI2_2hA HEK293_TMG_2hB NUP88 protein_coding   55.21346 39.65294 76.27686 6.913958 3.295627 0.9436429 8.285121 4.269260 14.547273 0.4650543 2.227909 1.7663068 0.1365375 0.1106333 0.18900000 0.07836667 0.03374277 0.03374277 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000108559 E001 1.6263069 0.0088905747 8.611220e-01 9.144208e-01 17 5360963 5361813 851 - 0.412 0.381 -0.169
ENSG00000108559 E002 0.4396707 0.0322230486 2.788128e-01 4.184776e-01 17 5361814 5362086 273 - 0.225 0.000 -9.343
ENSG00000108559 E003 34.3864053 0.0005974573 3.820652e-01 5.263180e-01 17 5384833 5386089 1257 - 1.514 1.569 0.189
ENSG00000108559 E004 6.3312277 0.0027627038 1.879467e-08 2.202928e-07 17 5386090 5386101 12 - 0.448 1.164 2.910
ENSG00000108559 E005 7.1427383 0.0024228304 1.783442e-09 2.522530e-08 17 5386102 5386103 2 - 0.482 1.216 2.926
ENSG00000108559 E006 10.0860948 0.0018298760 3.334291e-05 1.960252e-04 17 5386104 5386112 9 - 0.823 1.252 1.578
ENSG00000108559 E007 17.4101643 0.0010794957 1.103919e-02 3.125417e-02 17 5386113 5386137 25 - 1.170 1.379 0.735
ENSG00000108559 E008 179.7491513 0.0024443151 3.254062e-04 1.482510e-03 17 5386138 5386269 132 - 2.194 2.325 0.437
ENSG00000108559 E009 0.2934659 0.0282612999 5.956008e-01   17 5386613 5386625 13 - 0.088 0.167 1.050
ENSG00000108559 E010 1.0350216 0.0201507231 8.088071e-01 8.785899e-01 17 5386626 5386686 61 - 0.328 0.287 -0.273
ENSG00000108559 E011 1.1801942 0.0117308454 6.349329e-01 7.493203e-01 17 5386687 5386703 17 - 0.372 0.287 -0.535
ENSG00000108559 E012 42.9688919 0.0041815013 1.924249e-01 3.168107e-01 17 5386704 5386707 4 - 1.601 1.686 0.289
ENSG00000108559 E013 301.9401204 0.0048288843 9.106261e-03 2.654776e-02 17 5386708 5386826 119 - 2.428 2.531 0.343
ENSG00000108559 E014 299.8781626 0.0002813069 1.032045e-05 6.840353e-05 17 5386984 5387069 86 - 2.429 2.527 0.325
ENSG00000108559 E015 178.3919111 0.0006703700 4.448921e-03 1.439710e-02 17 5387070 5387083 14 - 2.210 2.295 0.284
ENSG00000108559 E016 147.9936983 0.0009463278 3.030376e-06 2.264856e-05 17 5387084 5387089 6 - 2.100 2.253 0.512
ENSG00000108559 E017 170.9781453 0.0003780300 1.323616e-04 6.692335e-04 17 5387090 5387110 21 - 2.180 2.290 0.370
ENSG00000108559 E018 2.0054344 0.1239583402 2.426902e-01 3.773357e-01 17 5387111 5387132 22 - 0.373 0.623 1.232
ENSG00000108559 E019 287.6839115 0.0008333128 1.517121e-03 5.691593e-03 17 5387386 5387466 81 - 2.418 2.499 0.268
ENSG00000108559 E020 4.7242096 0.0167303889 6.792723e-01 7.835057e-01 17 5387467 5387543 77 - 0.724 0.788 0.261
ENSG00000108559 E021 2.6656068 0.0067827886 4.758258e-01 6.145104e-01 17 5387544 5387604 61 - 0.513 0.631 0.536
ENSG00000108559 E022 254.8077491 0.0002044756 3.553095e-03 1.187816e-02 17 5387605 5387670 66 - 2.370 2.439 0.231
ENSG00000108559 E023 238.4131380 0.0019048469 6.140725e-03 1.898032e-02 17 5387779 5387904 126 - 2.335 2.418 0.279
ENSG00000108559 E024 2.7237972 0.0114578023 9.638380e-01 9.811709e-01 17 5387905 5387952 48 - 0.570 0.580 0.049
ENSG00000108559 E025 7.4312459 0.0785866525 9.097567e-01 9.466437e-01 17 5387953 5388250 298 - 0.904 0.960 0.212
ENSG00000108559 E026 14.2195173 0.0134608367 4.039894e-01 5.477343e-01 17 5388376 5388801 426 - 1.135 1.217 0.291
ENSG00000108559 E027 307.5374651 0.0002391488 5.495655e-01 6.792818e-01 17 5388802 5388960 159 - 2.483 2.472 -0.036
ENSG00000108559 E028 3.5460056 0.0043905781 8.363818e-01 8.976636e-01 17 5391475 5391560 86 - 0.642 0.676 0.144
ENSG00000108559 E029 278.3490018 0.0002033541 7.228395e-03 2.181681e-02 17 5391561 5391662 102 - 2.456 2.397 -0.196
ENSG00000108559 E030 239.0556573 0.0004993583 1.705460e-01 2.888665e-01 17 5394891 5394981 91 - 2.380 2.347 -0.113
ENSG00000108559 E031 240.2949851 0.0018432568 1.683800e-01 2.860776e-01 17 5399552 5399650 99 - 2.386 2.343 -0.144
ENSG00000108559 E032 262.7688323 0.0001910282 1.122669e-01 2.088518e-01 17 5404099 5404246 148 - 2.423 2.388 -0.116
ENSG00000108559 E033 313.8767271 0.0010220034 5.349707e-03 1.688271e-02 17 5405057 5405243 187 - 2.511 2.440 -0.239
ENSG00000108559 E034 110.6262307 0.0028942653 6.000412e-03 1.861100e-02 17 5408733 5408736 4 - 2.078 1.958 -0.401
ENSG00000108559 E035 313.4546531 0.0010630823 1.217270e-05 7.928495e-05 17 5408737 5408909 173 - 2.523 2.408 -0.385
ENSG00000108559 E036 219.4963217 0.0008694481 4.348570e-04 1.908625e-03 17 5410703 5410789 87 - 2.365 2.262 -0.341
ENSG00000108559 E037 200.3554261 0.0046819437 1.002590e-02 2.882691e-02 17 5414009 5414099 91 - 2.330 2.214 -0.385
ENSG00000108559 E038 114.2973209 0.0008489506 2.991273e-01 4.406181e-01 17 5414100 5414134 35 - 2.063 2.025 -0.128
ENSG00000108559 E039 114.7324807 0.0003059495 7.153065e-02 1.458835e-01 17 5416513 5416552 40 - 2.073 2.011 -0.207
ENSG00000108559 E040 170.3875717 0.0012848661 6.927825e-07 5.954142e-06 17 5416553 5416682 130 - 2.276 2.106 -0.567
ENSG00000108559 E041 1.9845057 0.1646613016 9.017487e-01 9.414029e-01 17 5418015 5418116 102 - 0.448 0.465 0.088
ENSG00000108559 E042 0.7384326 0.0719110316 9.502040e-02 1.829069e-01 17 5418117 5418141 25 - 0.088 0.383 2.645
ENSG00000108559 E043 0.0000000       17 5418142 5418229 88 -      
ENSG00000108559 E044 213.7796970 0.0011486581 5.063648e-09 6.601699e-08 17 5419354 5419746 393 - 2.377 2.196 -0.604