ENSG00000108557

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000353383 ENSG00000108557 HEK293_OSMI2_2hA HEK293_TMG_2hB RAI1 protein_coding protein_coding 11.46404 14.95883 8.982914 1.666999 0.5939137 -0.7351013 6.0854569 7.944607 5.1521392 1.0310762 0.2174870 -0.6238216 0.53193750 0.52873333 0.58233333 0.05360000 7.801092e-01 3.651203e-08 FALSE TRUE
ENST00000395774 ENSG00000108557 HEK293_OSMI2_2hA HEK293_TMG_2hB RAI1 protein_coding protein_coding 11.46404 14.95883 8.982914 1.666999 0.5939137 -0.7351013 0.6455922 0.000000 1.1469046 0.0000000 0.5013578 6.8541261 0.07808333 0.00000000 0.12406667 0.12406667 3.651203e-08 3.651203e-08 FALSE TRUE
ENST00000582514 ENSG00000108557 HEK293_OSMI2_2hA HEK293_TMG_2hB RAI1 protein_coding processed_transcript 11.46404 14.95883 8.982914 1.666999 0.5939137 -0.7351013 2.6707970 5.132296 0.7482061 0.5187325 0.2673020 -2.7617507 0.20375417 0.34423333 0.08006667 -0.26416667 4.014090e-04 3.651203e-08   FALSE
ENST00000583166 ENSG00000108557 HEK293_OSMI2_2hA HEK293_TMG_2hB RAI1 protein_coding protein_coding 11.46404 14.95883 8.982914 1.666999 0.5939137 -0.7351013 1.3656767 1.031618 1.1476296 0.1386902 0.3437104 0.1523470 0.12378333 0.06923333 0.12526667 0.05603333 3.060868e-01 3.651203e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000108557 E001 2.6520052 0.1100000196 1.173381e-02 3.289826e-02 17 17681431 17681457 27 + 0.829 0.293 -2.576
ENSG00000108557 E002 13.6411493 0.0610671025 9.891264e-05 5.167587e-04 17 17681458 17681728 271 + 1.453 0.835 -2.230
ENSG00000108557 E003 12.8829006 0.0014314536 1.700723e-04 8.353180e-04 17 17681729 17681793 65 + 1.346 0.926 -1.512
ENSG00000108557 E004 0.0000000       17 17682495 17682563 69 +      
ENSG00000108557 E005 5.3015204 0.0034934255 1.148989e-01 2.126914e-01 17 17683546 17683703 158 + 0.657 0.814 0.642
ENSG00000108557 E006 17.4126188 0.0010792042 2.357662e-04 1.115681e-03 17 17683704 17685050 1347 + 1.030 1.295 0.944
ENSG00000108557 E007 29.1713553 0.0059980504 6.960984e-04 2.884946e-03 17 17724028 17724159 132 + 1.633 1.312 -1.104
ENSG00000108557 E008 0.6277178 0.0224674634 1.553025e-01 2.687997e-01 17 17782132 17782215 84 + 0.367 0.093 -2.467
ENSG00000108557 E009 1117.9912372 0.0052030010 1.096706e-10 1.921995e-09 17 17792933 17798383 5451 + 3.124 2.953 -0.568
ENSG00000108557 E010 72.1953833 0.0003528216 3.724123e-02 8.593576e-02 17 17798384 17798513 130 + 1.813 1.826 0.043
ENSG00000108557 E011 68.8282957 0.0004193971 1.190969e-01 2.186484e-01 17 17803756 17803849 94 + 1.807 1.799 -0.029
ENSG00000108557 E012 8.7497732 0.0020849531 9.608953e-02 1.845074e-01 17 17803850 17804114 265 + 1.112 0.859 -0.936
ENSG00000108557 E013 6.2583518 0.0028167220 1.837734e-01 3.059504e-01 17 17809282 17809389 108 + 0.734 0.845 0.442
ENSG00000108557 E014 52.2390041 0.0025862889 3.065212e-02 7.323596e-02 17 17809390 17809439 50 + 1.655 1.700 0.152
ENSG00000108557 E015 297.7562722 0.0007346991 7.669427e-23 6.692538e-21 17 17809970 17810733 764 + 2.319 2.479 0.531
ENSG00000108557 E016 217.1965123 0.0166892429 8.133183e-06 5.514700e-05 17 17810734 17811453 720 + 2.149 2.359 0.703