ENSG00000108523

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262482 ENSG00000108523 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF167 protein_coding protein_coding 156.0525 240.0174 107.7023 5.04708 1.969187 -1.156016 44.089684 64.849986 34.178962 6.601561 1.4667144 -0.9237981 0.28766667 0.269366667 0.31766667 0.048300000 4.529878e-01 2.664913e-48 FALSE  
ENST00000571365 ENSG00000108523 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF167 protein_coding processed_transcript 156.0525 240.0174 107.7023 5.04708 1.969187 -1.156016 4.347517 1.356663 8.422366 1.356663 1.4151923 2.6252803 0.03475000 0.005433333 0.07776667 0.072333333 3.203353e-02 2.664913e-48    
ENST00000572382 ENSG00000108523 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF167 protein_coding protein_coding 156.0525 240.0174 107.7023 5.04708 1.969187 -1.156016 14.191041 21.109871 5.636666 1.301973 0.5617117 -1.9031297 0.08975833 0.088066667 0.05233333 -0.035733333 9.396598e-03 2.664913e-48 FALSE  
ENST00000575111 ENSG00000108523 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF167 protein_coding protein_coding 156.0525 240.0174 107.7023 5.04708 1.969187 -1.156016 16.979117 22.366741 13.975119 2.144461 2.4431126 -0.6781074 0.11594167 0.093133333 0.12973333 0.036600000 4.982170e-01 2.664913e-48 FALSE  
MSTRG.13483.10 ENSG00000108523 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF167 protein_coding   156.0525 240.0174 107.7023 5.04708 1.969187 -1.156016 13.039966 22.795327 0.000000 2.212077 0.0000000 -11.1551551 0.07241667 0.095266667 0.00000000 -0.095266667 2.664913e-48 2.664913e-48 FALSE  
MSTRG.13483.11 ENSG00000108523 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF167 protein_coding   156.0525 240.0174 107.7023 5.04708 1.969187 -1.156016 9.405111 25.465219 4.853485 1.944283 0.5176118 -2.3890322 0.05172083 0.106500000 0.04510000 -0.061400000 1.090217e-04 2.664913e-48 FALSE  
MSTRG.13483.8 ENSG00000108523 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF167 protein_coding   156.0525 240.0174 107.7023 5.04708 1.969187 -1.156016 8.639644 13.997476 5.786967 1.298688 1.1186496 -1.2728267 0.05576250 0.058133333 0.05380000 -0.004333333 8.752386e-01 2.664913e-48 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000108523 E001 11.00297 2.260265e-02 1.489769e-01 2.602874e-01 17 4940008 4940045 38 + 1.148 0.976 -0.623
ENSG00000108523 E002 21.45966 6.134367e-03 3.390563e-01 4.829600e-01 17 4940046 4940082 37 + 1.350 1.270 -0.280
ENSG00000108523 E003 39.01212 6.368747e-04 4.794628e-01 6.178416e-01 17 4940083 4940099 17 + 1.568 1.527 -0.140
ENSG00000108523 E004 49.28313 4.726822e-04 2.949488e-01 4.360532e-01 17 4940100 4940106 7 + 1.676 1.621 -0.187
ENSG00000108523 E005 79.09401 5.769991e-04 2.271256e-01 3.589696e-01 17 4940107 4940119 13 + 1.876 1.824 -0.173
ENSG00000108523 E006 280.18759 2.104688e-04 9.803527e-01 9.917228e-01 17 4940120 4940230 111 + 2.378 2.381 0.008
ENSG00000108523 E007 127.35333 2.390335e-04 2.530941e-02 6.251357e-02 17 4940231 4940267 37 + 2.096 2.021 -0.251
ENSG00000108523 E008 151.02759 2.261941e-04 1.544072e-04 7.666818e-04 17 4940268 4940298 31 + 2.199 2.082 -0.392
ENSG00000108523 E009 270.68469 1.600989e-04 6.049164e-04 2.551477e-03 17 4940299 4940360 62 + 2.424 2.344 -0.266
ENSG00000108523 E010 61.56833 8.315142e-03 3.011719e-02 7.219356e-02 17 4940381 4940486 106 + 1.831 1.691 -0.472
ENSG00000108523 E011 735.76084 1.736200e-03 1.717402e-04 8.426309e-04 17 4940487 4940642 156 + 2.863 2.777 -0.287
ENSG00000108523 E012 513.35853 5.399004e-03 2.192512e-02 5.551893e-02 17 4940643 4940657 15 + 2.705 2.622 -0.275
ENSG00000108523 E013 475.52846 5.189040e-03 2.665939e-02 6.528292e-02 17 4940658 4940658 1 + 2.669 2.590 -0.263
ENSG00000108523 E014 750.22598 3.163308e-03 1.575502e-02 4.218476e-02 17 4940659 4940726 68 + 2.858 2.791 -0.222
ENSG00000108523 E015 845.06361 1.274412e-03 4.712467e-01 6.103817e-01 17 4940727 4940872 146 + 2.867 2.856 -0.034
ENSG00000108523 E016 542.82538 2.483658e-04 8.217595e-02 1.629485e-01 17 4940873 4940922 50 + 2.638 2.674 0.120
ENSG00000108523 E017 616.10746 1.138902e-03 4.323728e-01 5.748196e-01 17 4940923 4940975 53 + 2.703 2.726 0.077
ENSG00000108523 E018 529.85136 1.027765e-03 9.396369e-01 9.660863e-01 17 4940976 4940993 18 + 2.651 2.657 0.021
ENSG00000108523 E019 850.45395 6.217827e-04 4.409601e-01 5.826131e-01 17 4941077 4941157 81 + 2.847 2.865 0.062
ENSG00000108523 E020 957.45941 3.039908e-04 3.937293e-02 8.986089e-02 17 4942341 4942466 126 + 2.885 2.920 0.118
ENSG00000108523 E021 20.76579 1.286999e-03 8.019154e-05 4.287904e-04 17 4942467 4942532 66 + 1.480 1.176 -1.061
ENSG00000108523 E022 798.98816 6.277878e-04 2.549576e-01 3.917383e-01 17 4942577 4942618 42 + 2.815 2.840 0.084
ENSG00000108523 E023 849.40498 8.579621e-05 3.736252e-01 5.180383e-01 17 4942619 4942664 46 + 2.849 2.865 0.053
ENSG00000108523 E024 1162.39806 8.497628e-05 6.904006e-02 1.417840e-01 17 4942851 4942941 91 + 2.977 3.002 0.086
ENSG00000108523 E025 25.07600 7.869864e-04 1.599740e-15 5.891641e-14 17 4942942 4943038 97 + 1.690 1.146 -1.887
ENSG00000108523 E026 28.76272 1.784328e-03 1.956929e-12 4.571223e-11 17 4943068 4943178 111 + 1.708 1.241 -1.608
ENSG00000108523 E027 1434.19509 1.863674e-04 2.150942e-01 3.445593e-01 17 4943179 4943284 106 + 3.075 3.094 0.063
ENSG00000108523 E028 22.13780 1.238235e-02 3.798377e-05 2.201257e-04 17 4943285 4943425 141 + 1.550 1.186 -1.265
ENSG00000108523 E029 813.02869 1.448313e-04 4.775049e-01 6.160407e-01 17 4943426 4943429 4 + 2.848 2.841 -0.023
ENSG00000108523 E030 1492.21824 1.048779e-03 9.027513e-01 9.420759e-01 17 4943430 4943519 90 + 3.105 3.108 0.012
ENSG00000108523 E031 21.56785 8.797998e-04 9.826660e-04 3.900583e-03 17 4944380 4944557 178 + 1.465 1.215 -0.870
ENSG00000108523 E032 1345.20471 1.568955e-03 2.597966e-01 3.972564e-01 17 4944558 4944638 81 + 3.039 3.070 0.101
ENSG00000108523 E033 83.98001 7.429404e-04 3.069308e-06 2.290970e-05 17 4944639 4944714 76 + 1.676 1.910 0.790
ENSG00000108523 E034 2678.56660 2.672158e-03 3.001044e-03 1.026799e-02 17 4944715 4945222 508 + 3.302 3.379 0.255