ENSG00000108479

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000225614 ENSG00000108479 HEK293_OSMI2_2hA HEK293_TMG_2hB GALK1 protein_coding protein_coding 52.37623 112.6615 20.83352 5.675758 0.8645461 -2.434452 2.836872 5.257492 1.371816 1.106808 0.1693132 -1.930551 0.06047083 0.04623333 0.06616667 0.01993333 0.452303706 0.001165891 FALSE  
ENST00000588479 ENSG00000108479 HEK293_OSMI2_2hA HEK293_TMG_2hB GALK1 protein_coding protein_coding 52.37623 112.6615 20.83352 5.675758 0.8645461 -2.434452 45.650465 101.376561 17.083268 4.711044 0.5173949 -2.568366 0.84825000 0.90023333 0.82083333 -0.07940000 0.001282633 0.001165891 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000108479 E001 12.1396799 0.0016364634 1.245338e-02 0.0346261930 17 75751594 75751678 85 - 1.185 0.885 -1.101
ENSG00000108479 E002 11.6788901 0.0016791120 2.497762e-01 0.3856507752 17 75751679 75751737 59 - 1.045 0.892 -0.571
ENSG00000108479 E003 67.2319280 0.0004270587 6.515797e-01 0.7624237329 17 75757894 75757971 78 - 1.608 1.634 0.088
ENSG00000108479 E004 173.1245143 0.0007467055 8.395740e-01 0.8997786937 17 75757972 75758033 62 - 2.033 2.038 0.018
ENSG00000108479 E005 410.1015172 0.0025311931 3.821020e-01 0.5263484796 17 75758034 75758127 94 - 2.383 2.414 0.102
ENSG00000108479 E006 661.0207547 0.0014267510 3.288985e-02 0.0775815396 17 75758210 75758359 150 - 2.566 2.623 0.189
ENSG00000108479 E007 347.8581648 0.0001932965 4.685465e-01 0.6079567906 17 75758360 75758372 13 - 2.360 2.335 -0.082
ENSG00000108479 E008 14.8305591 0.0013496168 7.572807e-01 0.8421653294 17 75758373 75758448 76 - 1.045 1.003 -0.156
ENSG00000108479 E009 506.6184191 0.0007826805 6.061199e-02 0.1276625325 17 75758449 75758511 63 - 2.458 2.507 0.162
ENSG00000108479 E010 584.2982777 0.0001495025 3.592375e-02 0.0834362709 17 75758512 75758590 79 - 2.523 2.567 0.146
ENSG00000108479 E011 352.9316383 0.0002128062 2.097593e-01 0.3382612731 17 75758591 75758599 9 - 2.315 2.347 0.110
ENSG00000108479 E012 510.2137476 0.0001247152 2.317041e-02 0.0581014421 17 75762704 75762757 54 - 2.457 2.508 0.171
ENSG00000108479 E013 438.4788841 0.0001762113 2.316286e-01 0.3644024071 17 75762758 75762795 38 - 2.411 2.438 0.091
ENSG00000108479 E014 566.8753387 0.0001176721 3.734860e-01 0.5179220825 17 75762796 75762885 90 - 2.569 2.545 -0.079
ENSG00000108479 E015 9.1336104 0.0018949479 2.649318e-02 0.0649362721 17 75762886 75763013 128 - 1.077 0.781 -1.120
ENSG00000108479 E016 704.0964286 0.0002042319 8.064778e-02 0.1605674463 17 75763014 75763149 136 - 2.677 2.638 -0.128
ENSG00000108479 E017 14.3110989 0.0018557323 1.350252e-03 0.0051440054 17 75763150 75763181 32 - 1.290 0.938 -1.270
ENSG00000108479 E018 13.9705475 0.0030354332 2.653162e-05 0.0001598606 17 75763182 75763319 138 - 1.360 0.912 -1.610
ENSG00000108479 E019 506.4772110 0.0001342151 4.116005e-01 0.5551428770 17 75763320 75763382 63 - 2.520 2.496 -0.078
ENSG00000108479 E020 421.2205530 0.0009378130 5.528267e-01 0.6820664868 17 75763383 75763439 57 - 2.438 2.418 -0.070
ENSG00000108479 E021 2.3821794 0.0069138103 3.967626e-01 0.5405295142 17 75763440 75763580 141 - 0.547 0.377 -0.867
ENSG00000108479 E022 0.8407440 0.0157645081 1.507824e-02 0.0406663579 17 75763581 75763667 87 - 0.547 0.098 -3.324
ENSG00000108479 E023 0.3268771 0.0296730056 1.731518e-01   17 75763668 75763896 229 - 0.266 0.052 -2.743
ENSG00000108479 E024 649.8985728 0.0024863079 1.168499e-01 0.2154711176 17 75763897 75764086 190 - 2.653 2.603 -0.165
ENSG00000108479 E025 483.5671698 0.0084013004 2.070684e-01 0.3350256496 17 75764972 75765236 265 - 2.534 2.474 -0.198