ENSG00000108469

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000317905 ENSG00000108469 HEK293_OSMI2_2hA HEK293_TMG_2hB RECQL5 protein_coding protein_coding 26.18372 27.70112 18.20207 2.613409 0.4385993 -0.6055697 6.597594 8.7781207 4.065175 1.0001539 0.3819841 -1.1086927 0.24987083 0.31643333 0.22393333 -0.092500000 0.087486898 0.007732668 FALSE TRUE
ENST00000578201 ENSG00000108469 HEK293_OSMI2_2hA HEK293_TMG_2hB RECQL5 protein_coding protein_coding 26.18372 27.70112 18.20207 2.613409 0.4385993 -0.6055697 2.303912 0.7093195 2.854435 0.7093195 0.4849941 1.9935460 0.09626250 0.02160000 0.15570000 0.134100000 0.066179283 0.007732668 FALSE TRUE
ENST00000578865 ENSG00000108469 HEK293_OSMI2_2hA HEK293_TMG_2hB RECQL5 protein_coding retained_intron 26.18372 27.70112 18.20207 2.613409 0.4385993 -0.6055697 4.898720 7.6315156 2.915495 1.0140521 0.4145519 -1.3851782 0.18047500 0.27553333 0.15926667 -0.116266667 0.036966671 0.007732668 FALSE TRUE
ENST00000579265 ENSG00000108469 HEK293_OSMI2_2hA HEK293_TMG_2hB RECQL5 protein_coding retained_intron 26.18372 27.70112 18.20207 2.613409 0.4385993 -0.6055697 5.112659 3.4007593 3.820979 0.6068644 0.3148758 0.1676202 0.19228333 0.12096667 0.21016667 0.089200000 0.007732668 0.007732668 FALSE FALSE
ENST00000585205 ENSG00000108469 HEK293_OSMI2_2hA HEK293_TMG_2hB RECQL5 protein_coding retained_intron 26.18372 27.70112 18.20207 2.613409 0.4385993 -0.6055697 2.440980 1.9596589 1.574581 0.2932785 0.3809083 -0.3138440 0.09495833 0.07123333 0.08593333 0.014700000 0.866874052 0.007732668 TRUE FALSE
MSTRG.15083.8 ENSG00000108469 HEK293_OSMI2_2hA HEK293_TMG_2hB RECQL5 protein_coding   26.18372 27.70112 18.20207 2.613409 0.4385993 -0.6055697 2.240339 2.5271744 1.791307 0.5341257 0.5224192 -0.4941782 0.08917083 0.09620000 0.09986667 0.003666667 1.000000000 0.007732668 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000108469 E001 1.7714029 0.0096730410 8.074936e-01 8.776916e-01 17 75626845 75626853 9 - 0.455 0.415 -0.214
ENSG00000108469 E002 28.3076469 0.0366557047 3.068472e-01 4.490324e-01 17 75626854 75626909 56 - 1.330 1.468 0.479
ENSG00000108469 E003 64.2569956 0.0079211928 1.348510e-01 2.408946e-01 17 75626910 75627002 93 - 1.700 1.804 0.351
ENSG00000108469 E004 74.6004350 0.0055568829 6.439683e-02 1.340341e-01 17 75627003 75627047 45 - 1.756 1.869 0.380
ENSG00000108469 E005 66.6673542 0.0004833444 8.368108e-02 1.653141e-01 17 75627048 75627060 13 - 1.727 1.813 0.289
ENSG00000108469 E006 155.2073778 0.0023985236 1.570437e-03 5.863165e-03 17 75627061 75627224 164 - 2.057 2.185 0.427
ENSG00000108469 E007 217.4985707 0.0006241261 2.875597e-04 1.329364e-03 17 75627225 75627522 298 - 2.216 2.323 0.356
ENSG00000108469 E008 105.8767216 0.0003203391 1.016560e-01 1.930128e-01 17 75627623 75627692 70 - 1.938 2.003 0.218
ENSG00000108469 E009 154.5669112 0.0007850165 3.759858e-02 8.657581e-02 17 75628218 75628396 179 - 2.094 2.167 0.242
ENSG00000108469 E010 86.9565505 0.0084974316 4.355580e-02 9.756678e-02 17 75628397 75628442 46 - 1.806 1.934 0.432
ENSG00000108469 E011 113.1437506 0.0061836893 3.478732e-03 1.166352e-02 17 75628672 75628762 91 - 1.894 2.056 0.543
ENSG00000108469 E012 17.3700854 0.0012322050 7.944840e-02 1.586565e-01 17 75628763 75628825 63 - 1.100 1.264 0.584
ENSG00000108469 E013 6.9542042 0.0173338229 4.612272e-01 6.012146e-01 17 75628826 75628874 49 - 0.925 0.828 -0.374
ENSG00000108469 E014 176.9935624 0.0015655546 7.915128e-04 3.228961e-03 17 75628934 75629317 384 - 2.118 2.238 0.402
ENSG00000108469 E015 95.2307393 0.0004443280 5.382470e-01 6.696962e-01 17 75629318 75629475 158 - 1.917 1.944 0.092
ENSG00000108469 E016 22.7159125 0.0054092802 4.650567e-06 3.334731e-05 17 75629561 75629707 147 - 1.548 1.189 -1.247
ENSG00000108469 E017 73.4489514 0.0004387889 8.312272e-01 8.942031e-01 17 75629708 75629774 67 - 1.816 1.828 0.042
ENSG00000108469 E018 75.0374255 0.0004440296 3.777677e-01 5.220691e-01 17 75629775 75629842 68 - 1.860 1.824 -0.121
ENSG00000108469 E019 88.9538004 0.0034375294 2.343889e-01 3.676211e-01 17 75630184 75630277 94 - 1.947 1.893 -0.184
ENSG00000108469 E020 20.4154836 0.0029494594 3.389163e-03 1.140600e-02 17 75630278 75630618 341 - 1.438 1.207 -0.806
ENSG00000108469 E021 61.1524099 0.0007081710 6.236164e-01 7.401571e-01 17 75630619 75630692 74 - 1.763 1.742 -0.072
ENSG00000108469 E022 58.2988026 0.0006865574 3.280068e-01 4.714598e-01 17 75630779 75630837 59 - 1.760 1.714 -0.155
ENSG00000108469 E023 42.7419148 0.0070197104 8.210617e-01 8.872013e-01 17 75630974 75631010 37 - 1.586 1.603 0.059
ENSG00000108469 E024 72.3585421 0.0033129896 8.940771e-01 9.362679e-01 17 75631150 75631249 100 - 1.825 1.820 -0.017
ENSG00000108469 E025 41.0579971 0.0005156139 8.495115e-01 9.066283e-01 17 75631450 75631456 7 - 1.586 1.578 -0.028
ENSG00000108469 E026 45.9156559 0.0004633825 9.179321e-01 9.521413e-01 17 75631457 75631465 9 - 1.621 1.629 0.029
ENSG00000108469 E027 43.9532217 0.0004960158 4.654217e-01 6.051415e-01 17 75631466 75631491 26 - 1.575 1.620 0.153
ENSG00000108469 E028 98.0326674 0.0003944815 6.487186e-01 7.601815e-01 17 75631492 75631668 177 - 1.933 1.954 0.070
ENSG00000108469 E029 2.0866372 0.0255544012 2.202606e-01 3.507297e-01 17 75633459 75634223 765 - 0.285 0.517 1.304
ENSG00000108469 E030 0.8480291 0.0140371952 9.269898e-02 1.793473e-01 17 75638546 75638761 216 - 0.000 0.331 13.182
ENSG00000108469 E031 0.4782907 0.0220921377 2.617253e-01 3.994078e-01 17 75638762 75638903 142 - 0.000 0.226 12.419
ENSG00000108469 E032 0.3697384 0.0274424043 4.720403e-01 6.111173e-01 17 75638904 75638977 74 - 0.000 0.164 11.817
ENSG00000108469 E033 0.2214452 0.0376836531 1.000000e+00   17 75638978 75639021 44 - 0.000 0.090 10.770
ENSG00000108469 E034 0.4428904 0.3984484271 5.793856e-01 7.042944e-01 17 75639022 75639199 178 - 0.000 0.170 10.853
ENSG00000108469 E035 0.2955422 0.0289080194 6.023286e-01   17 75639869 75639990 122 - 0.165 0.089 -1.022
ENSG00000108469 E036 8.3800961 0.0020859390 6.016784e-05 3.322534e-04 17 75648865 75650358 1494 - 0.455 1.043 2.439
ENSG00000108469 E037 1.0632334 0.0136432757 9.827875e-01 9.933054e-01 17 75650359 75650361 3 - 0.285 0.282 -0.017
ENSG00000108469 E038 5.2574975 0.0032022926 1.479748e-02 4.003911e-02 17 75650362 75650516 155 - 0.455 0.842 1.681
ENSG00000108469 E039 9.6556667 0.0018812325 2.956610e-02 7.110569e-02 17 75650517 75650718 202 - 0.785 1.052 1.013
ENSG00000108469 E040 4.8241459 0.0035288438 7.824825e-02 1.566544e-01 17 75650719 75651094 376 - 0.521 0.796 1.182
ENSG00000108469 E041 2.0468964 0.1655422144 3.137618e-01 4.563977e-01 17 75651095 75651185 91 - 0.284 0.515 1.299
ENSG00000108469 E042 75.1453853 0.0003757117 3.067952e-01 4.489840e-01 17 75651186 75651265 80 - 1.800 1.848 0.163
ENSG00000108469 E043 0.1482932 0.0412347934 1.000000e+00   17 75652448 75652566 119 - 0.000 0.089 10.743
ENSG00000108469 E044 102.1524458 0.0002927629 6.259597e-01 7.419705e-01 17 75658298 75658460 163 - 1.980 1.965 -0.051
ENSG00000108469 E045 87.6051154 0.0003284508 4.085817e-01 5.521921e-01 17 75660955 75661066 112 - 1.926 1.896 -0.102
ENSG00000108469 E046 75.1876388 0.0019168267 1.655615e-01 2.824389e-01 17 75661606 75661708 103 - 1.884 1.822 -0.209
ENSG00000108469 E047 112.3153586 0.0047761790 4.301418e-03 1.398869e-02 17 75662479 75662655 177 - 2.102 1.971 -0.439
ENSG00000108469 E048 146.6231982 0.0003592979 3.283428e-05 1.934869e-04 17 75662656 75662967 312 - 2.210 2.085 -0.418
ENSG00000108469 E049 59.1859545 0.0079925455 3.527070e-01 4.969422e-01 17 75662968 75662997 30 - 1.770 1.715 -0.187
ENSG00000108469 E050 62.8300472 0.0008985860 4.454984e-01 5.870330e-01 17 75665051 75665091 41 - 1.780 1.746 -0.116
ENSG00000108469 E051 73.6088769 0.0044570608 4.735924e-01 6.125303e-01 17 75665092 75665172 81 - 1.848 1.814 -0.116
ENSG00000108469 E052 95.9267867 0.0062643448 9.146797e-02 1.774288e-01 17 75666428 75666571 144 - 1.998 1.914 -0.285
ENSG00000108469 E053 25.0071282 0.0017595568 1.976922e-03 7.155285e-03 17 75666572 75666620 49 - 1.518 1.300 -0.753
ENSG00000108469 E054 45.9431177 0.0005127848 4.965820e-09 6.485761e-08 17 75666621 75666900 280 - 1.816 1.513 -1.029
ENSG00000108469 E055 52.7605596 0.0035333249 1.823651e-12 4.282790e-11 17 75666901 75667043 143 - 1.919 1.532 -1.312
ENSG00000108469 E056 64.9564076 0.0008303380 1.836661e-04 8.935312e-04 17 75667044 75667189 146 - 1.886 1.716 -0.575