ENSG00000108448

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000449552 ENSG00000108448 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIM16L transcribed_unprocessed_pseudogene processed_transcript 6.714539 9.444659 6.187127 0.4897194 0.2006468 -0.6094259 0.51705836 0.5857385 0.3972610 0.0654679 0.10812758 -0.5487255 0.083137500 0.06273333 0.06516667 0.002433333 1.000000e+00 8.851666e-13 FALSE TRUE
ENST00000449697 ENSG00000108448 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIM16L transcribed_unprocessed_pseudogene processed_transcript 6.714539 9.444659 6.187127 0.4897194 0.2006468 -0.6094259 0.57929221 0.9941459 0.5296421 0.4976442 0.26760458 -0.8958940 0.083025000 0.10353333 0.08310000 -0.020433333 9.923127e-01 8.851666e-13   FALSE
ENST00000581904 ENSG00000108448 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIM16L transcribed_unprocessed_pseudogene processed_transcript 6.714539 9.444659 6.187127 0.4897194 0.2006468 -0.6094259 0.07575172 0.6060138 0.0000000 0.6060138 0.00000000 -5.9448907 0.008370833 0.06696667 0.00000000 -0.066966667 8.793684e-01 8.851666e-13 TRUE FALSE
ENST00000641936 ENSG00000108448 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIM16L transcribed_unprocessed_pseudogene processed_transcript 6.714539 9.444659 6.187127 0.4897194 0.2006468 -0.6094259 1.34822493 2.4173812 0.9870196 0.4222772 0.18086733 -1.2837068 0.189833333 0.25386667 0.15993333 -0.093933333 2.998413e-01 8.851666e-13 FALSE TRUE
MSTRG.13807.1 ENSG00000108448 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIM16L transcribed_unprocessed_pseudogene   6.714539 9.444659 6.187127 0.4897194 0.2006468 -0.6094259 0.63846719 0.8858727 0.9997457 0.4851366 0.29559992 0.1726262 0.096520833 0.09436667 0.16190000 0.067533333 6.962064e-01 8.851666e-13 FALSE TRUE
MSTRG.13807.10 ENSG00000108448 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIM16L transcribed_unprocessed_pseudogene   6.714539 9.444659 6.187127 0.4897194 0.2006468 -0.6094259 0.71108075 0.6416626 0.4116495 0.3627203 0.41164953 -0.6280809 0.106937500 0.06770000 0.06370000 -0.004000000 6.822315e-01 8.851666e-13 TRUE TRUE
MSTRG.13807.3 ENSG00000108448 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIM16L transcribed_unprocessed_pseudogene   6.714539 9.444659 6.187127 0.4897194 0.2006468 -0.6094259 0.29636237 0.0000000 0.6516027 0.0000000 0.06945672 6.0478932 0.051270833 0.00000000 0.10626667 0.106266667 8.851666e-13 8.851666e-13 FALSE TRUE
MSTRG.13807.5 ENSG00000108448 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIM16L transcribed_unprocessed_pseudogene   6.714539 9.444659 6.187127 0.4897194 0.2006468 -0.6094259 0.52032916 0.8183666 0.4790064 0.4202305 0.12615570 -0.7604161 0.086662500 0.08633333 0.07753333 -0.008800000 9.339638e-01 8.851666e-13 FALSE TRUE
MSTRG.13807.6 ENSG00000108448 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIM16L transcribed_unprocessed_pseudogene   6.714539 9.444659 6.187127 0.4897194 0.2006468 -0.6094259 0.81273647 1.2164185 0.9195788 0.6275337 0.33452833 -0.3998023 0.116704167 0.12546667 0.14543333 0.019966667 8.864566e-01 8.851666e-13 TRUE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000108448 E001 0.5149242 0.2918626992 0.8956406613 0.9373456582 17 18697994 18697997 4 + 0.149 0.182 0.345
ENSG00000108448 E002 0.5149242 0.2918626992 0.8956406613 0.9373456582 17 18697998 18698003 6 + 0.149 0.182 0.345
ENSG00000108448 E003 0.8073459 0.0196654267 0.3451608923 0.4892387590 17 18698004 18698006 3 + 0.348 0.181 -1.245
ENSG00000108448 E004 0.9556391 0.0125566641 0.5779755522 0.7031458118 17 18698007 18698007 1 + 0.348 0.249 -0.662
ENSG00000108448 E005 1.2522254 0.0108647759 0.9516016408 0.9737015037 17 18698008 18698009 2 + 0.348 0.360 0.074
ENSG00000108448 E006 1.2522254 0.0108647759 0.9516016408 0.9737015037 17 18698010 18698010 1 + 0.348 0.360 0.074
ENSG00000108448 E007 1.8370794 0.0078885408 0.4321154342 0.5745722127 17 18698011 18698012 2 + 0.348 0.487 0.753
ENSG00000108448 E008 26.1447643 0.0007323782 0.0511196757 0.1111662386 17 18698013 18698114 102 + 1.495 1.366 -0.445
ENSG00000108448 E009 17.8557578 0.0274430127 0.9537887230 0.9750487833 17 18698115 18699153 1039 + 1.259 1.243 -0.058
ENSG00000108448 E010 31.6226996 0.0014185375 0.8397456389 0.8998964389 17 18699154 18699214 61 + 1.501 1.488 -0.045
ENSG00000108448 E011 31.7301645 0.0010088134 0.6327157665 0.7475186080 17 18699215 18699275 61 + 1.472 1.502 0.105
ENSG00000108448 E012 21.0774294 0.0069004951 0.6241298438 0.7405653157 17 18699360 18699457 98 + 1.356 1.318 -0.130
ENSG00000108448 E013 31.2491835 0.0079564366 0.5777764296 0.7029845750 17 18701357 18701445 89 + 1.517 1.473 -0.153
ENSG00000108448 E014 9.0593110 0.0060514307 0.0032971578 0.0111414928 17 18704129 18704618 490 + 0.707 1.075 1.410
ENSG00000108448 E015 14.6384372 0.0046591948 0.4716840137 0.6107561486 17 18704619 18704639 21 + 1.219 1.152 -0.237
ENSG00000108448 E016 14.6039052 0.0014898871 0.8992233834 0.9397039612 17 18704640 18704657 18 + 1.185 1.175 -0.036
ENSG00000108448 E017 27.8025013 0.0008991303 0.5041173549 0.6400063021 17 18704658 18704765 108 + 1.472 1.429 -0.147
ENSG00000108448 E018 0.2924217 0.0274157838 0.1054780739   17 18704766 18704769 4 + 0.260 0.000 -11.970
ENSG00000108448 E019 21.6922017 0.0057092512 0.5572735266 0.6857222512 17 18705063 18705164 102 + 1.371 1.325 -0.163
ENSG00000108448 E020 4.4797824 0.0201242798 0.9142640909 0.9497115258 17 18718899 18719036 138 + 0.741 0.730 -0.044
ENSG00000108448 E021 19.8271681 0.0020756080 0.0001986811 0.0009581637 17 18720102 18720325 224 + 1.466 1.182 -0.990
ENSG00000108448 E022 0.0000000       17 18721777 18721862 86 +      
ENSG00000108448 E023 0.0000000       17 18722023 18722117 95 +      
ENSG00000108448 E024 0.0000000       17 18722118 18722118 1 +      
ENSG00000108448 E025 0.0000000       17 18722119 18722120 2 +      
ENSG00000108448 E026 0.0000000       17 18722121 18722122 2 +      
ENSG00000108448 E027 0.5106578 0.2880892961 0.8939459226 0.9361805669 17 18722123 18722236 114 + 0.149 0.182 0.348
ENSG00000108448 E028 13.6663544 0.0014440593 0.1524476350 0.2650071765 17 18722237 18722246 10 + 1.229 1.102 -0.455
ENSG00000108448 E029 24.0239705 0.0009270836 0.1426656899 0.2516511666 17 18722247 18722332 86 + 1.447 1.347 -0.349
ENSG00000108448 E030 1.6209328 0.0926316571 0.9278186906 0.9585776165 17 18723770 18723831 62 + 0.421 0.406 -0.085
ENSG00000108448 E031 30.1976508 0.0007979024 0.0285605582 0.0691332278 17 18727525 18727621 97 + 1.563 1.429 -0.461
ENSG00000108448 E032 14.6505238 0.0321678846 0.5019930255 0.6381226064 17 18727622 18727650 29 + 1.230 1.158 -0.253
ENSG00000108448 E033 24.7530890 0.0067913371 0.7093171317 0.8067310795 17 18727651 18727702 52 + 1.379 1.413 0.118
ENSG00000108448 E034 26.8326050 0.0007620525 0.7959312398 0.8696975460 17 18727703 18727758 56 + 1.441 1.425 -0.055
ENSG00000108448 E035 35.3009916 0.0030182919 0.8712591562 0.9212052558 17 18731070 18731235 166 + 1.554 1.547 -0.023
ENSG00000108448 E036 15.1223253 0.0049460569 0.1894728449 0.3130838383 17 18732039 18732040 2 + 1.109 1.237 0.453
ENSG00000108448 E037 28.1352523 0.0008573779 0.7447374587 0.8329613750 17 18732041 18732134 94 + 1.434 1.457 0.079
ENSG00000108448 E038 52.2030474 0.0013576768 0.9459631390 0.9700706336 17 18734877 18735201 325 + 1.703 1.707 0.011
ENSG00000108448 E039 86.4708527 0.0014197365 0.0014041827 0.0053200447 17 18735202 18735770 569 + 1.833 1.964 0.441
ENSG00000108448 E040 48.9116117 0.0019710299 0.0020656159 0.0074279129 17 18735771 18736016 246 + 1.564 1.735 0.584
ENSG00000108448 E041 20.0136378 0.0036997613 0.4005089543 0.5442090432 17 18736017 18736118 102 + 1.260 1.330 0.247
ENSG00000108448 E042 0.1817044 0.0406517566 0.7181040471   17 18736213 18736273 61 + 0.000 0.100 9.129