ENSG00000108424

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000290158 ENSG00000108424 HEK293_OSMI2_2hA HEK293_TMG_2hB KPNB1 protein_coding protein_coding 281.1559 171.4698 412.9415 20.33756 3.227941 1.267934 24.92184 25.237513 29.99477 3.792048 0.8153468 0.2490508 0.10339583 0.14706667 0.072666667 -0.07440000 1.933196e-05 2.817666e-77 FALSE TRUE
ENST00000577875 ENSG00000108424 HEK293_OSMI2_2hA HEK293_TMG_2hB KPNB1 protein_coding protein_coding 281.1559 171.4698 412.9415 20.33756 3.227941 1.267934 21.18567 2.665485 43.62749 2.665485 4.7698872 4.0276959 0.06872083 0.01520000 0.105733333 0.09053333 6.322057e-02 2.817666e-77 FALSE FALSE
ENST00000577918 ENSG00000108424 HEK293_OSMI2_2hA HEK293_TMG_2hB KPNB1 protein_coding processed_transcript 281.1559 171.4698 412.9415 20.33756 3.227941 1.267934 46.10622 16.398367 76.41428 5.936092 4.4067632 2.2195993 0.14178333 0.09296667 0.184900000 0.09193333 9.171596e-02 2.817666e-77 FALSE TRUE
ENST00000579901 ENSG00000108424 HEK293_OSMI2_2hA HEK293_TMG_2hB KPNB1 protein_coding processed_transcript 281.1559 171.4698 412.9415 20.33756 3.227941 1.267934 20.48981 0.000000 34.56450 0.000000 1.7867042 11.7554925 0.05695000 0.00000000 0.083800000 0.08380000 2.817666e-77 2.817666e-77 FALSE FALSE
ENST00000677341 ENSG00000108424 HEK293_OSMI2_2hA HEK293_TMG_2hB KPNB1 protein_coding retained_intron 281.1559 171.4698 412.9415 20.33756 3.227941 1.267934 13.34480 37.201926 1.16291 6.191823 0.2746264 -4.9876004 0.07470000 0.22136667 0.002833333 -0.21853333 1.242031e-28 2.817666e-77 FALSE TRUE
MSTRG.14561.14 ENSG00000108424 HEK293_OSMI2_2hA HEK293_TMG_2hB KPNB1 protein_coding   281.1559 171.4698 412.9415 20.33756 3.227941 1.267934 72.94342 42.653489 108.88464 5.544290 2.3789067 1.3518591 0.25769167 0.24973333 0.263600000 0.01386667 8.167543e-01 2.817666e-77 FALSE TRUE
MSTRG.14561.5 ENSG00000108424 HEK293_OSMI2_2hA HEK293_TMG_2hB KPNB1 protein_coding   281.1559 171.4698 412.9415 20.33756 3.227941 1.267934 30.83730 20.498534 43.97148 1.927118 3.9320545 1.1006718 0.11498333 0.12603333 0.106400000 -0.01963333 8.475147e-01 2.817666e-77 FALSE TRUE
MSTRG.14561.6 ENSG00000108424 HEK293_OSMI2_2hA HEK293_TMG_2hB KPNB1 protein_coding   281.1559 171.4698 412.9415 20.33756 3.227941 1.267934 33.43762 20.676443 44.52874 8.032395 2.4094321 1.1063752 0.11990417 0.11336667 0.107866667 -0.00550000 1.000000e+00 2.817666e-77 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000108424 E001 1.7026957 7.988282e-03 2.600038e-02 6.394679e-02 17 47649476 47649494 19 + 0.550 0.151 -2.617
ENSG00000108424 E002 26.9570766 1.228586e-03 1.450574e-01 2.549134e-01 17 47649495 47649877 383 + 1.474 1.392 -0.283
ENSG00000108424 E003 25.1046311 2.042646e-03 2.022378e-02 5.195523e-02 17 47649919 47649924 6 + 1.467 1.313 -0.534
ENSG00000108424 E004 55.6165046 1.514290e-02 5.364027e-03 1.691973e-02 17 47649925 47649937 13 + 1.823 1.615 -0.707
ENSG00000108424 E005 59.7986208 1.352802e-02 4.966324e-03 1.583612e-02 17 47649938 47649942 5 + 1.852 1.652 -0.679
ENSG00000108424 E006 168.7176456 3.247451e-03 8.068264e-09 1.011654e-07 17 47649943 47650003 61 + 2.305 2.087 -0.727
ENSG00000108424 E007 182.0069167 3.705485e-03 4.548353e-09 5.973876e-08 17 47650004 47650102 99 + 2.340 2.115 -0.754
ENSG00000108424 E008 65.7817862 1.023033e-02 6.588820e-05 3.602921e-04 17 47650103 47650151 49 + 1.912 1.660 -0.853
ENSG00000108424 E009 74.2972653 3.618653e-04 1.012456e-01 1.923664e-01 17 47650152 47650177 26 + 1.896 1.847 -0.165
ENSG00000108424 E010 172.4641282 1.088972e-03 1.417020e-03 5.363749e-03 17 47650178 47650215 38 + 2.271 2.189 -0.275
ENSG00000108424 E011 346.3829821 6.557787e-03 5.404626e-04 2.311473e-03 17 47650216 47650284 69 + 2.589 2.457 -0.439
ENSG00000108424 E012 0.5933762 2.312942e-02 9.762426e-02 1.868633e-01 17 47650358 47650385 28 + 0.305 0.000 -11.707
ENSG00000108424 E013 499.7300986 7.356943e-03 5.982280e-05 3.305793e-04 17 47650386 47650444 59 + 2.757 2.597 -0.530
ENSG00000108424 E014 16.9117868 3.926271e-02 1.039686e-01 1.965467e-01 17 47651196 47651376 181 + 1.315 1.132 -0.646
ENSG00000108424 E015 1263.8991885 3.611793e-03 3.833791e-11 7.254298e-10 17 47652694 47652876 183 + 3.168 2.982 -0.620
ENSG00000108424 E016 1035.0460302 1.037556e-03 1.125766e-20 7.809334e-19 17 47656860 47656924 65 + 3.075 2.911 -0.544
ENSG00000108424 E017 1544.2729962 2.391734e-03 1.050081e-11 2.178727e-10 17 47656925 47657060 136 + 3.245 3.089 -0.517
ENSG00000108424 E018 1609.9296597 2.546428e-03 4.660474e-10 7.333772e-09 17 47658508 47658660 153 + 3.259 3.113 -0.486
ENSG00000108424 E019 3.4752471 8.749938e-03 2.777665e-02 6.757243e-02 17 47660882 47660904 23 + 0.767 0.425 -1.545
ENSG00000108424 E020 3.7676688 4.850072e-03 1.304186e-02 3.600930e-02 17 47660905 47660935 31 + 0.803 0.425 -1.689
ENSG00000108424 E021 7.5309299 2.183041e-03 2.001847e-03 7.231545e-03 17 47660936 47661118 183 + 1.049 0.676 -1.448
ENSG00000108424 E022 1034.8691890 3.185010e-03 1.419112e-08 1.701021e-07 17 47661119 47661178 60 + 3.070 2.918 -0.504
ENSG00000108424 E023 1.3381516 3.417094e-02 9.414645e-01 9.671955e-01 17 47662169 47662238 70 + 0.357 0.352 -0.029
ENSG00000108424 E024 0.7321044 5.222045e-01 9.318350e-01 9.610604e-01 17 47662550 47662650 101 + 0.246 0.254 0.063
ENSG00000108424 E025 1141.6932276 3.137097e-03 1.806575e-07 1.746174e-06 17 47663089 47663178 90 + 3.107 2.969 -0.460
ENSG00000108424 E026 1314.6461618 1.120141e-03 1.524890e-12 3.626004e-11 17 47664159 47664269 111 + 3.162 3.043 -0.395
ENSG00000108424 E027 606.2571258 1.398537e-04 9.948727e-12 2.073211e-10 17 47665057 47665060 4 + 2.815 2.728 -0.292
ENSG00000108424 E028 1249.2546413 5.071228e-04 3.683167e-14 1.114285e-12 17 47665061 47665158 98 + 3.132 3.036 -0.319
ENSG00000108424 E029 1616.0643968 2.350598e-04 3.014868e-17 1.382613e-15 17 47668186 47668364 179 + 3.238 3.158 -0.264
ENSG00000108424 E030 868.4390626 5.407678e-04 8.366294e-04 3.389946e-03 17 47668365 47668410 46 + 2.952 2.915 -0.124
ENSG00000108424 E031 6.6796996 2.507780e-03 8.352789e-02 1.650700e-01 17 47668411 47668801 391 + 0.950 0.746 -0.790
ENSG00000108424 E032 7.3169708 2.208801e-03 1.011253e-02 2.903810e-02 17 47669573 47669677 105 + 1.018 0.712 -1.183
ENSG00000108424 E033 1594.7052509 7.760858e-04 5.129873e-04 2.208380e-03 17 47669678 47669869 192 + 3.216 3.176 -0.133
ENSG00000108424 E034 0.4439371 2.155869e-02 1.803244e-01 3.015799e-01 17 47670324 47670343 20 + 0.247 0.000 -11.292
ENSG00000108424 E035 1.1761433 4.715336e-02 1.308354e-02 3.610332e-02 17 47670377 47670457 81 + 0.483 0.000 -12.706
ENSG00000108424 E036 1321.4336773 1.077437e-03 7.371964e-04 3.033048e-03 17 47670702 47670832 131 + 3.137 3.090 -0.158
ENSG00000108424 E037 0.0000000       17 47671710 47671862 153 +      
ENSG00000108424 E038 1257.5124969 3.761373e-04 2.046777e-04 9.840518e-04 17 47673018 47673088 71 + 3.111 3.077 -0.112
ENSG00000108424 E039 1384.2773091 1.272499e-04 7.417974e-07 6.338076e-06 17 47673089 47673165 77 + 3.154 3.118 -0.118
ENSG00000108424 E040 1466.5824550 9.664593e-05 9.433495e-06 6.307430e-05 17 47673490 47673561 72 + 3.175 3.148 -0.090
ENSG00000108424 E041 1.3726095 9.825007e-03 6.350605e-02 1.325324e-01 17 47673562 47673839 278 + 0.483 0.151 -2.296
ENSG00000108424 E042 1859.0178139 2.370487e-04 5.837818e-01 7.078216e-01 17 47674638 47674782 145 + 3.262 3.273 0.037
ENSG00000108424 E043 11.7988728 2.556311e-02 2.149999e-03 7.690187e-03 17 47675714 47676076 363 + 1.226 0.835 -1.437
ENSG00000108424 E044 14.7218358 1.197103e-03 4.276769e-01 5.705219e-01 17 47676077 47676408 332 + 1.219 1.167 -0.183
ENSG00000108424 E045 1357.3201858 2.695225e-04 3.030294e-02 7.256549e-02 17 47676409 47676491 83 + 3.111 3.155 0.147
ENSG00000108424 E046 1302.3652524 5.606426e-04 1.423389e-01 2.512267e-01 17 47677020 47677127 108 + 3.095 3.134 0.128
ENSG00000108424 E047 1572.4738812 1.211798e-04 5.376227e-05 3.005341e-04 17 47678046 47678189 144 + 3.168 3.229 0.200
ENSG00000108424 E048 1646.9235481 2.048844e-04 8.790437e-11 1.566477e-09 17 47678308 47678413 106 + 3.174 3.264 0.298
ENSG00000108424 E049 99.7877850 3.158314e-04 2.372886e-06 1.816087e-05 17 47678414 47680019 1606 + 2.060 1.903 -0.527
ENSG00000108424 E050 1893.7066036 3.034085e-04 2.154462e-05 1.325570e-04 17 47680020 47680134 115 + 3.245 3.312 0.222
ENSG00000108424 E051 2154.1907605 7.181680e-04 1.451521e-07 1.429243e-06 17 47680508 47680602 95 + 3.288 3.381 0.308
ENSG00000108424 E052 1846.6357196 3.225478e-04 3.347621e-15 1.182320e-13 17 47680603 47680669 67 + 3.214 3.324 0.367
ENSG00000108424 E053 3263.1372010 4.639440e-04 2.021672e-40 7.185735e-38 17 47682404 47682790 387 + 3.430 3.601 0.569
ENSG00000108424 E054 5092.6302030 3.039289e-03 9.164697e-19 5.088582e-17 17 47682791 47684312 1522 + 3.587 3.822 0.780
ENSG00000108424 E055 860.9846051 6.113427e-03 5.033543e-08 5.425830e-07 17 47684313 47685505 1193 + 2.813 3.054 0.801