ENSG00000108395

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262294 ENSG00000108395 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIM37 protein_coding protein_coding 13.60602 6.221251 19.415 0.2704436 1.235072 1.640321 9.1751523 4.293156304 13.1345371 0.318313725 0.9073327 1.6109962 0.6885667 0.6883 0.67700000 -0.01130000 0.931742237 0.002815233 FALSE  
ENST00000393065 ENSG00000108395 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIM37 protein_coding protein_coding 13.60602 6.221251 19.415 0.2704436 1.235072 1.640321 1.1022139 0.006696599 1.4142899 0.006696599 0.5378067 6.4145448 0.0550625 0.0010 0.07226667 0.07126667 0.002815233 0.002815233 FALSE  
ENST00000583945 ENSG00000108395 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIM37 protein_coding protein_coding 13.60602 6.221251 19.415 0.2704436 1.235072 1.640321 0.6624132 0.421021713 0.6692607 0.421021713 0.3753996 0.6562049 0.0521875 0.0689 0.03233333 -0.03656667 0.796351033 0.002815233    
ENST00000585287 ENSG00000108395 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIM37 protein_coding protein_coding 13.60602 6.221251 19.415 0.2704436 1.235072 1.640321 1.1960180 1.007916354 1.6272131 0.504033540 0.1260919 0.6856231 0.1048000 0.1613 0.08376667 -0.07753333 0.964696911 0.002815233 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000108395 E001 1.6596283 0.0087559996 2.388452e-03 8.425066e-03 17 58960628 58960758 131 - 0.184 0.717 2.996
ENSG00000108395 E002 2.7763373 0.0053291748 3.726645e-01 5.170925e-01 17 58962159 58962281 123 - 0.493 0.664 0.773
ENSG00000108395 E003 1.4790604 0.0091635142 3.916198e-02 8.948077e-02 17 58969911 58970099 189 - 0.441 0.000 -12.943
ENSG00000108395 E004 0.0000000       17 58979972 58979973 2 -      
ENSG00000108395 E005 0.2924217 0.0290785164 7.956191e-01   17 58979974 58982637 2664 - 0.131 0.000 -10.621
ENSG00000108395 E006 0.2934659 0.0286616457 3.963723e-01   17 58982638 58982650 13 - 0.070 0.204 1.772
ENSG00000108395 E007 16.0604452 0.0011677901 5.207790e-06 3.690709e-05 17 58982651 58982921 271 - 1.028 1.448 1.485
ENSG00000108395 E008 0.1482932 0.0409921379 1.428578e-01   17 58998200 58998201 2 - 0.000 0.204 12.892
ENSG00000108395 E009 230.2593158 0.0101833239 2.397786e-12 5.531580e-11 17 58998202 58998986 785 - 2.170 2.561 1.303
ENSG00000108395 E010 140.7906921 0.0023316365 1.532300e-04 7.613956e-04 17 58998987 58999380 394 - 2.045 2.220 0.586
ENSG00000108395 E011 88.2628318 0.0004076974 1.489786e-01 2.602880e-01 17 58999381 58999459 79 - 1.870 1.960 0.303
ENSG00000108395 E012 102.1644222 0.0005970177 2.603034e-02 6.400718e-02 17 59001598 59001714 117 - 1.926 2.043 0.393
ENSG00000108395 E013 6.2700939 0.0232421996 9.597928e-01 9.787165e-01 17 59001715 59001741 27 - 0.810 0.845 0.137
ENSG00000108395 E014 104.3895770 0.0004144157 1.324995e-01 2.375564e-01 17 59012328 59012446 119 - 1.946 2.034 0.295
ENSG00000108395 E015 125.0856380 0.0002627013 1.545082e-01 2.677676e-01 17 59015610 59015799 190 - 2.023 2.103 0.268
ENSG00000108395 E016 91.6468194 0.0003034216 4.178582e-01 5.611738e-01 17 59017296 59017424 129 - 1.894 1.958 0.212
ENSG00000108395 E017 118.8373765 0.0002508641 9.161210e-01 9.509730e-01 17 59028415 59028723 309 - 2.014 2.048 0.113
ENSG00000108395 E018 68.1726528 0.0012557599 6.968455e-01 7.971023e-01 17 59031896 59032090 195 - 1.784 1.795 0.036
ENSG00000108395 E019 54.7495694 0.0008508313 9.743912e-01 9.880166e-01 17 59041813 59041898 86 - 1.684 1.712 0.095
ENSG00000108395 E020 78.9398920 0.0005708247 2.258293e-03 8.024962e-03 17 59047683 59047819 137 - 1.876 1.760 -0.392
ENSG00000108395 E021 108.6323714 0.0004952676 6.175642e-02 1.295791e-01 17 59049178 59049393 216 - 1.996 1.952 -0.150
ENSG00000108395 E022 85.1553984 0.0132749085 6.484663e-01 7.599659e-01 17 59051214 59051328 115 - 1.879 1.873 -0.022
ENSG00000108395 E023 106.0303606 0.0005983390 1.854279e-01 3.080371e-01 17 59056875 59057054 180 - 1.979 1.955 -0.081
ENSG00000108395 E024 58.6236379 0.0004315950 3.931256e-02 8.975014e-02 17 59061032 59061088 57 - 1.740 1.658 -0.278
ENSG00000108395 E025 44.9246707 0.0004821016 5.647149e-02 1.205462e-01 17 59061089 59061108 20 - 1.629 1.540 -0.301
ENSG00000108395 E026 73.8276052 0.0004181947 4.601645e-03 1.482447e-02 17 59062567 59062648 82 - 1.846 1.737 -0.368
ENSG00000108395 E027 0.1515154 0.0424458851 1.000000e+00   17 59064152 59064354 203 - 0.070 0.000 -9.621
ENSG00000108395 E028 66.0877212 0.0131947522 2.590277e-02 6.374564e-02 17 59064355 59064405 51 - 1.805 1.658 -0.498
ENSG00000108395 E029 75.2890383 0.0043030338 2.654512e-02 6.504589e-02 17 59070823 59070884 62 - 1.853 1.755 -0.331
ENSG00000108395 E030 64.6062671 0.0005272733 2.918029e-01 4.327227e-01 17 59070885 59070947 63 - 1.770 1.746 -0.080
ENSG00000108395 E031 0.4375944 0.0246256980 4.739288e-01 6.128042e-01 17 59073094 59073141 48 - 0.184 0.000 -11.205
ENSG00000108395 E032 55.3066483 0.0005323558 2.846344e-01 4.248913e-01 17 59075647 59075683 37 - 1.704 1.675 -0.098
ENSG00000108395 E033 47.4685948 0.0043928134 3.642372e-01 5.086101e-01 17 59075684 59075714 31 - 1.641 1.609 -0.107
ENSG00000108395 E034 1.4769841 0.0088936647 3.922514e-02 8.959807e-02 17 59076654 59076729 76 - 0.441 0.000 -12.943
ENSG00000108395 E035 64.2819642 0.0034522749 2.578350e-01 3.950168e-01 17 59079754 59079797 44 - 1.771 1.736 -0.118
ENSG00000108395 E036 84.2357079 0.0003665030 5.330280e-03 1.682981e-02 17 59079798 59079877 80 - 1.900 1.803 -0.326
ENSG00000108395 E037 104.7917073 0.0002609944 8.897185e-05 4.701922e-04 17 59081097 59081219 123 - 2.000 1.868 -0.444
ENSG00000108395 E038 74.3126021 0.0003450952 1.021059e-06 8.451810e-06 17 59084002 59084089 88 - 1.871 1.653 -0.740
ENSG00000108395 E039 0.3729606 0.0262416082 3.934906e-01 5.373857e-01 17 59087979 59087979 1 - 0.070 0.205 1.777
ENSG00000108395 E040 0.3729606 0.0262416082 3.934906e-01 5.373857e-01 17 59087980 59088225 246 - 0.070 0.205 1.777
ENSG00000108395 E041 0.4031496 0.0255031644 3.067726e-02 7.328678e-02 17 59088226 59088290 65 - 0.000 0.344 13.899
ENSG00000108395 E042 70.2415702 0.0003584314 1.416646e-04 7.107129e-04 17 59088291 59088407 117 - 1.835 1.670 -0.559
ENSG00000108395 E043 1.1082873 0.0157942802 7.750591e-01 8.550600e-01 17 59090017 59090052 36 - 0.274 0.343 0.453
ENSG00000108395 E044 0.9536514 0.1916925645 7.888412e-01 8.648399e-01 17 59090053 59090092 40 - 0.274 0.207 -0.525
ENSG00000108395 E045 37.1816740 0.0019791465 5.600711e-03 1.755523e-02 17 59091300 59091340 41 - 1.563 1.389 -0.597
ENSG00000108395 E046 40.0130681 0.0005441514 4.277003e-03 1.391922e-02 17 59104293 59104394 102 - 1.593 1.430 -0.560
ENSG00000108395 E047 61.1408595 0.0006063356 2.499282e-04 1.174979e-03 17 59106441 59106921 481 - 1.778 1.603 -0.591