ENSG00000108389

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000323456 ENSG00000108389 HEK293_OSMI2_2hA HEK293_TMG_2hB MTMR4 protein_coding protein_coding 18.22944 12.7938 18.60209 1.20311 0.162283 0.5396689 13.4541737 10.0464904 12.005675 1.77906595 0.4162586 0.2567908 0.73967917 0.77896667 0.6458667 -0.13310000 0.5011055176 1.329578e-09 FALSE  
ENST00000579925 ENSG00000108389 HEK293_OSMI2_2hA HEK293_TMG_2hB MTMR4 protein_coding protein_coding 18.22944 12.7938 18.60209 1.20311 0.162283 0.5396689 0.4210413 1.3462490 0.000000 0.67591265 0.0000000 -7.0834783 0.02868333 0.10483333 0.0000000 -0.10483333 0.1171618769 1.329578e-09 FALSE  
ENST00000582390 ENSG00000108389 HEK293_OSMI2_2hA HEK293_TMG_2hB MTMR4 protein_coding nonsense_mediated_decay 18.22944 12.7938 18.60209 1.20311 0.162283 0.5396689 0.9424243 0.1780305 1.243690 0.05771858 0.1246112 2.7371418 0.04691250 0.01446667 0.0668000 0.05233333 0.0001426575 1.329578e-09 TRUE  
ENST00000682306 ENSG00000108389 HEK293_OSMI2_2hA HEK293_TMG_2hB MTMR4 protein_coding protein_coding 18.22944 12.7938 18.60209 1.20311 0.162283 0.5396689 1.6409998 0.7882833 2.692399 0.26717152 0.5353571 1.7592677 0.09518333 0.06406667 0.1442667 0.08020000 0.1967333219 1.329578e-09 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000108389 E001 0.6663248 0.0217461750 2.666145e-02 6.528450e-02 17 58489529 58489536 8 - 0.000 0.409 11.381
ENSG00000108389 E002 992.8360841 0.0069648121 2.730308e-16 1.114520e-14 17 58489537 58491475 1939 - 2.811 3.148 1.118
ENSG00000108389 E003 60.5544985 0.0044133508 6.087721e-02 1.281132e-01 17 58491476 58491480 5 - 1.696 1.895 0.671
ENSG00000108389 E004 246.2596799 0.0003682868 4.881384e-01 6.257520e-01 17 58491481 58491840 360 - 2.345 2.455 0.365
ENSG00000108389 E005 105.0812508 0.0003234509 1.656652e-01 2.825675e-01 17 58492511 58492599 89 - 2.009 2.054 0.152
ENSG00000108389 E006 2.3606886 0.4009254060 3.599263e-01 5.042369e-01 17 58492600 58492738 139 - 0.568 0.431 -0.670
ENSG00000108389 E007 105.4453146 0.0002800794 3.759832e-01 5.203566e-01 17 58492842 58492952 111 - 2.002 2.065 0.211
ENSG00000108389 E008 537.0570424 0.0002230358 5.621276e-10 8.728967e-09 17 58494932 58496330 1399 - 2.734 2.732 -0.005
ENSG00000108389 E009 95.1230216 0.0042541987 2.292376e-01 3.615326e-01 17 58503744 58503898 155 - 1.970 2.000 0.100
ENSG00000108389 E010 90.4451738 0.0055424991 3.665894e-02 8.482559e-02 17 58504050 58504220 171 - 1.972 1.954 -0.059
ENSG00000108389 E011 87.5655728 0.0045732820 3.412464e-05 2.001551e-04 17 58504303 58504488 186 - 1.997 1.875 -0.411
ENSG00000108389 E012 77.4655903 0.0140969340 1.512621e-02 4.077368e-02 17 58504779 58504974 196 - 1.934 1.841 -0.312
ENSG00000108389 E013 55.3225814 0.0116499600 3.239079e-01 4.672457e-01 17 58505472 58505583 112 - 1.745 1.757 0.042
ENSG00000108389 E014 62.3318695 0.0328459848 1.387635e-01 2.463900e-01 17 58506743 58506871 129 - 1.827 1.767 -0.203
ENSG00000108389 E015 84.4243185 0.0003256237 8.214244e-05 4.381092e-04 17 58507123 58507319 197 - 1.960 1.902 -0.198
ENSG00000108389 E016 2.4131426 0.1749279478 1.559894e-01 2.697752e-01 17 58507985 58508160 176 - 0.629 0.343 -1.434
ENSG00000108389 E017 31.1583945 0.0009508790 2.168468e-02 5.502038e-02 17 58508161 58508167 7 - 1.535 1.482 -0.179
ENSG00000108389 E018 69.5464710 0.0003898081 2.018534e-05 1.250630e-04 17 58508168 58508274 107 - 1.888 1.799 -0.301
ENSG00000108389 E019 1.5405712 0.0322919799 1.853401e-02 4.830658e-02 17 58508322 58508467 146 - 0.535 0.144 -2.630
ENSG00000108389 E020 73.4596179 0.0003444476 5.847550e-09 7.544271e-08 17 58508468 58508564 97 - 1.935 1.785 -0.507
ENSG00000108389 E021 80.2425601 0.0022477233 4.179461e-07 3.755034e-06 17 58508681 58508841 161 - 1.969 1.829 -0.472
ENSG00000108389 E022 2.7658284 0.0166304326 1.876048e-01 3.107315e-01 17 58508842 58508876 35 - 0.628 0.472 -0.723
ENSG00000108389 E023 1.3381542 0.0096765512 1.798833e-03 6.595766e-03 17 58510597 58510631 35 - 0.536 0.000 -15.115
ENSG00000108389 E024 15.1932153 0.0012333337 2.347755e-09 3.250092e-08 17 58510735 58511428 694 - 1.365 0.884 -1.734
ENSG00000108389 E025 33.9528931 0.0007256068 3.202772e-04 1.461986e-03 17 58511429 58511447 19 - 1.598 1.471 -0.435
ENSG00000108389 E026 30.4445535 0.0006585216 2.567800e-04 1.203518e-03 17 58511448 58511450 3 - 1.558 1.416 -0.487
ENSG00000108389 E027 53.2061616 0.0008236889 3.084456e-06 2.301189e-05 17 58511451 58511511 61 - 1.793 1.652 -0.478
ENSG00000108389 E028 51.6495893 0.0018503100 2.529422e-08 2.890701e-07 17 58512390 58512506 117 - 1.804 1.595 -0.708
ENSG00000108389 E029 30.5151526 0.0102194444 3.349392e-05 1.968335e-04 17 58512852 58512941 90 - 1.595 1.338 -0.883
ENSG00000108389 E030 0.2965864 0.0531971522 1.698901e-01   17 58513988 58514036 49 - 0.000 0.250 12.193
ENSG00000108389 E031 11.4613971 0.0294166149 1.291710e-03 4.947946e-03 17 58514363 58514638 276 - 1.215 0.864 -1.288
ENSG00000108389 E032 0.5943067 0.0200120469 3.931451e-01 5.370340e-01 17 58514992 58515083 92 - 0.258 0.143 -1.051
ENSG00000108389 E033 6.1570975 0.0433156897 1.325213e-01 2.375842e-01 17 58516580 58516618 39 - 0.919 0.757 -0.631
ENSG00000108389 E034 4.8461135 0.2682311993 4.019564e-01 5.456628e-01 17 58517817 58517905 89 - 0.806 0.703 -0.415
ENSG00000108389 E035 1.5680304 0.1120134771 3.879157e-01 5.320347e-01 17 58518092 58518542 451 - 0.462 0.336 -0.697