ENSG00000108387

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000317256 ENSG00000108387 HEK293_OSMI2_2hA HEK293_TMG_2hB SEPTIN4 protein_coding protein_coding 1.293501 1.728313 1.185472 0.1869403 0.2006221 -0.5401074 0.10570230 0.09186115 0.00000000 0.091861150 0.00000000 -3.3485320 0.08038333 0.05426667 0.00000000 -0.05426667 7.917627e-01 1.201214e-05 FALSE TRUE
ENST00000393086 ENSG00000108387 HEK293_OSMI2_2hA HEK293_TMG_2hB SEPTIN4 protein_coding protein_coding 1.293501 1.728313 1.185472 0.1869403 0.2006221 -0.5401074 0.25629224 0.60094044 0.00000000 0.176813875 0.00000000 -5.9329598 0.18647083 0.34190000 0.00000000 -0.34190000 1.201214e-05 1.201214e-05 FALSE TRUE
ENST00000426861 ENSG00000108387 HEK293_OSMI2_2hA HEK293_TMG_2hB SEPTIN4 protein_coding protein_coding 1.293501 1.728313 1.185472 0.1869403 0.2006221 -0.5401074 0.03707009 0.03228476 0.07702421 0.032284764 0.07702421 1.0412788 0.03329583 0.01906667 0.07956667 0.06050000 9.685290e-01 1.201214e-05 TRUE TRUE
ENST00000577729 ENSG00000108387 HEK293_OSMI2_2hA HEK293_TMG_2hB SEPTIN4 protein_coding protein_coding 1.293501 1.728313 1.185472 0.1869403 0.2006221 -0.5401074 0.04740576 0.00000000 0.17645049 0.000000000 0.12306373 4.2207207 0.03104583 0.00000000 0.12680000 0.12680000 1.386025e-01 1.201214e-05 FALSE FALSE
ENST00000582270 ENSG00000108387 HEK293_OSMI2_2hA HEK293_TMG_2hB SEPTIN4 protein_coding retained_intron 1.293501 1.728313 1.185472 0.1869403 0.2006221 -0.5401074 0.08162516 0.09566464 0.04161419 0.031248463 0.02129085 -1.0336531 0.05937917 0.05813333 0.03356667 -0.02456667 8.091317e-01 1.201214e-05 TRUE TRUE
ENST00000582976 ENSG00000108387 HEK293_OSMI2_2hA HEK293_TMG_2hB SEPTIN4 protein_coding retained_intron 1.293501 1.728313 1.185472 0.1869403 0.2006221 -0.5401074 0.07218152 0.03633236 0.14103399 0.008430606 0.05942823 1.7047812 0.05981667 0.02256667 0.11386667 0.09130000 6.709460e-02 1.201214e-05 FALSE FALSE
MSTRG.14764.16 ENSG00000108387 HEK293_OSMI2_2hA HEK293_TMG_2hB SEPTIN4 protein_coding   1.293501 1.728313 1.185472 0.1869403 0.2006221 -0.5401074 0.40375403 0.70869961 0.50424414 0.184228166 0.09100226 -0.4829354 0.27991250 0.41606667 0.46136667 0.04530000 9.525979e-01 1.201214e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000108387 E001 0.0000000       17 58520250 58520254 5 -      
ENSG00000108387 E002 0.0000000       17 58520255 58520255 1 -      
ENSG00000108387 E003 0.2214452 0.050820103 1.000000000   17 58520256 58520257 2 - 0.000 0.086 9.204
ENSG00000108387 E004 2.1733048 0.007127993 0.044270619 0.098883423 17 58520258 58520298 41 - 0.173 0.556 2.411
ENSG00000108387 E005 3.3920173 0.098757338 0.073863977 0.149688273 17 58520299 58520358 60 - 0.296 0.697 2.027
ENSG00000108387 E006 4.3883397 0.096135056 0.025790060 0.063509502 17 58520359 58520425 67 - 0.296 0.794 2.417
ENSG00000108387 E007 2.6922814 0.013109068 0.075589969 0.152451677 17 58520426 58520434 9 - 0.296 0.626 1.726
ENSG00000108387 E008 6.6423749 0.050788012 0.243218306 0.377960042 17 58520435 58520485 51 - 0.691 0.893 0.802
ENSG00000108387 E009 6.7908571 0.071676540 0.539553970 0.670811279 17 58520743 58520789 47 - 0.770 0.873 0.403
ENSG00000108387 E010 7.9763724 0.078889137 0.421746667 0.564878262 17 58520790 58520842 53 - 0.805 0.941 0.523
ENSG00000108387 E011 1.5855193 0.026900010 0.413425769 0.556919286 17 58520843 58520997 155 - 0.470 0.320 -0.843
ENSG00000108387 E012 11.0457329 0.020872866 0.982161396 0.992889701 17 58520998 58521160 163 - 1.032 1.039 0.024
ENSG00000108387 E013 0.3634088 0.346133607 0.615300886   17 58521161 58521253 93 - 0.000 0.157 10.590
ENSG00000108387 E014 10.7665588 0.021729520 0.114030002 0.211396827 17 58521254 58521350 97 - 0.866 1.073 0.769
ENSG00000108387 E015 1.2072732 0.012526133 0.897177066 0.938331568 17 58521351 58521544 194 - 0.296 0.319 0.151
ENSG00000108387 E016 6.0656866 0.002987290 0.052610290 0.113804242 17 58521545 58521548 4 - 0.594 0.875 1.149
ENSG00000108387 E017 9.1237438 0.002785279 0.161048451 0.276483952 17 58521549 58521646 98 - 0.836 1.004 0.635
ENSG00000108387 E018 0.6621601 0.017267182 0.428414571 0.571185836 17 58521647 58521735 89 - 0.296 0.156 -1.171
ENSG00000108387 E019 3.7932796 0.004491466 0.180922966 0.302372284 17 58521736 58521747 12 - 0.470 0.690 0.998
ENSG00000108387 E020 9.1377394 0.002146932 0.908808897 0.946062736 17 58521748 58521853 106 - 0.969 0.955 -0.050
ENSG00000108387 E021 1.3253524 0.302393386 0.228903600 0.361139456 17 58521854 58521966 113 - 0.536 0.221 -1.875
ENSG00000108387 E022 6.3980541 0.002846729 0.491676676 0.628952932 17 58521967 58522020 54 - 0.894 0.807 -0.336
ENSG00000108387 E023 6.3355853 0.002920384 0.424351447 0.567328205 17 58522021 58522050 30 - 0.894 0.793 -0.394
ENSG00000108387 E024 8.0430079 0.032928576 0.661892110 0.770268039 17 58522051 58522101 51 - 0.968 0.888 -0.302
ENSG00000108387 E025 0.1515154 0.045906349 0.217751330   17 58524588 58525077 490 - 0.173 0.000 -12.199
ENSG00000108387 E026 5.7600048 0.117957954 0.438606327 0.580478905 17 58525078 58525083 6 - 0.919 0.716 -0.794
ENSG00000108387 E027 8.9694891 0.053238863 0.586744562 0.710241122 17 58525084 58525161 78 - 1.031 0.921 -0.407
ENSG00000108387 E028 5.4497148 0.085440240 0.918993365 0.952832141 17 58525162 58525201 40 - 0.769 0.782 0.050
ENSG00000108387 E029 0.0000000       17 58525202 58525694 493 -      
ENSG00000108387 E030 7.1199402 0.008079817 0.625241641 0.741411673 17 58525695 58525781 87 - 0.920 0.861 -0.227
ENSG00000108387 E031 3.6901421 0.004557949 0.316840895 0.459644817 17 58526220 58526222 3 - 0.732 0.582 -0.641
ENSG00000108387 E032 4.3502389 0.004229277 0.217038919 0.346815221 17 58526223 58526253 31 - 0.804 0.629 -0.724
ENSG00000108387 E033 4.8555982 0.003798072 0.414411634 0.557833505 17 58526254 58526313 60 - 0.804 0.691 -0.461
ENSG00000108387 E034 0.4815130 0.020614356 0.922129536 0.954876601 17 58526314 58526314 1 - 0.173 0.156 -0.173
ENSG00000108387 E035 0.6330284 0.093412963 0.438645886 0.580519093 17 58526315 58526410 96 - 0.296 0.156 -1.180
ENSG00000108387 E036 0.0000000       17 58526411 58526562 152 -      
ENSG00000108387 E037 0.0000000       17 58526563 58526576 14 -      
ENSG00000108387 E038 0.0000000       17 58526577 58526577 1 -      
ENSG00000108387 E039 0.3268771 0.028216364 0.555453039   17 58526578 58526681 104 - 0.173 0.085 -1.171
ENSG00000108387 E040 2.6360062 0.008123027 0.574165329 0.700019301 17 58526682 58526764 83 - 0.594 0.501 -0.435
ENSG00000108387 E041 1.7544642 0.010270273 0.695012952 0.795707570 17 58526765 58526766 2 - 0.470 0.401 -0.366
ENSG00000108387 E042 2.9723334 0.005746056 0.817432233 0.884555890 17 58526767 58526931 165 - 0.594 0.556 -0.172
ENSG00000108387 E043 1.8434090 0.007890116 0.803037720 0.874604541 17 58526932 58526978 47 - 0.392 0.437 0.243
ENSG00000108387 E044 0.5944058 0.527028959 0.908834295 0.946083976 17 58526979 58527141 163 - 0.173 0.164 -0.092
ENSG00000108387 E045 0.2214452 0.050820103 1.000000000   17 58527142 58527155 14 - 0.000 0.086 9.590
ENSG00000108387 E046 0.7697675 0.127142456 0.786526182 0.863296788 17 58527156 58527825 670 - 0.173 0.221 0.441
ENSG00000108387 E047 1.3640887 0.010101297 0.028210248 0.068432166 17 58527826 58528569 744 - 0.594 0.217 -2.173
ENSG00000108387 E048 1.2019878 0.310692662 0.499778444 0.636052660 17 58529115 58529351 237 - 0.172 0.362 1.414
ENSG00000108387 E049 3.6570376 0.112741121 0.002685424 0.009330157 17 58529818 58531479 1662 - 0.969 0.365 -2.659
ENSG00000108387 E050 1.7545514 0.180586366 0.650156999 0.761245561 17 58531480 58531551 72 - 0.470 0.368 -0.546
ENSG00000108387 E051 0.4741261 0.021768165 0.207156139 0.335121803 17 58531552 58531941 390 - 0.296 0.085 -2.171
ENSG00000108387 E052 3.0580586 0.005213981 0.297383272 0.438714256 17 58531961 58532075 115 - 0.691 0.529 -0.713
ENSG00000108387 E053 0.0000000       17 58532140 58532286 147 -      
ENSG00000108387 E054 0.0000000       17 58539112 58539208 97 -      
ENSG00000108387 E055 0.0000000       17 58540666 58540673 8 -      
ENSG00000108387 E056 0.0000000       17 58540674 58540818 145 -      
ENSG00000108387 E057 0.0000000       17 58541587 58541921 335 -      
ENSG00000108387 E058 0.0000000       17 58541922 58541966 45 -      
ENSG00000108387 E059 0.0000000       17 58542626 58544270 1645 -      
ENSG00000108387 E060 0.0000000       17 58544271 58544368 98 -