ENSG00000108344

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000264639 ENSG00000108344 HEK293_OSMI2_2hA HEK293_TMG_2hB PSMD3 protein_coding protein_coding 167.1625 266.6628 105.6952 5.084027 1.303624 -1.335024 154.149060 233.1351 101.4983873 16.71344 1.0772051 -1.199629 0.92587083 0.8727333 0.960333333 0.0876000 0.084956939 7.904539e-11 FALSE TRUE
MSTRG.14278.5 ENSG00000108344 HEK293_OSMI2_2hA HEK293_TMG_2hB PSMD3 protein_coding   167.1625 266.6628 105.6952 5.084027 1.303624 -1.335024 7.359835 27.5327 0.1430726 12.99707 0.1430726 -7.491310 0.03658333 0.1047667 0.001333333 -0.1034333 0.002044415 7.904539e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000108344 E001 6.262509 0.0026305299 2.803002e-02 6.807216e-02 17 39980777 39980806 30 + 0.993 0.702 -1.132
ENSG00000108344 E002 126.015962 0.0104928716 6.253120e-02 1.309032e-01 17 39980807 39980835 29 + 2.114 1.992 -0.409
ENSG00000108344 E003 862.850600 0.0104558170 2.308325e-02 5.792123e-02 17 39980836 39981090 255 + 2.945 2.827 -0.393
ENSG00000108344 E004 764.510358 0.0034769489 1.977003e-04 9.540164e-04 17 39981091 39981190 100 + 2.897 2.772 -0.417
ENSG00000108344 E005 1246.677048 0.0016684789 6.102666e-04 2.570552e-03 17 39984294 39984458 165 + 3.080 2.995 -0.282
ENSG00000108344 E006 771.785189 0.0024842887 1.072701e-03 4.210195e-03 17 39984459 39984484 26 + 2.882 2.783 -0.330
ENSG00000108344 E007 908.845506 0.0028978934 3.236762e-03 1.096381e-02 17 39986575 39986608 34 + 2.949 2.856 -0.309
ENSG00000108344 E008 1231.632518 0.0019684071 4.499105e-03 1.454037e-02 17 39986609 39986683 75 + 3.068 2.992 -0.252
ENSG00000108344 E009 942.734995 0.0016325532 2.316992e-02 5.810144e-02 17 39986684 39986712 29 + 2.941 2.880 -0.204
ENSG00000108344 E010 1539.312474 0.0006132408 5.168766e-01 6.513805e-01 17 39988683 39988819 137 + 3.122 3.103 -0.064
ENSG00000108344 E011 1067.590572 0.0002812575 3.073828e-03 1.048351e-02 17 39989739 39989793 55 + 2.921 2.955 0.114
ENSG00000108344 E012 1643.506726 0.0000621682 7.333592e-05 3.962260e-04 17 39989794 39989929 136 + 3.110 3.142 0.106
ENSG00000108344 E013 20.879990 0.0008681250 6.248315e-09 8.012443e-08 17 39989930 39990093 164 + 1.567 1.117 -1.570
ENSG00000108344 E014 1654.794646 0.0001181370 7.426759e-05 4.006085e-04 17 39990094 39990197 104 + 3.112 3.146 0.114
ENSG00000108344 E015 37.329417 0.0005764638 1.158523e-09 1.696651e-08 17 39992998 39994953 1956 + 1.758 1.388 -1.266
ENSG00000108344 E016 1856.394585 0.0003891798 2.649948e-02 6.494919e-02 17 39994954 39995068 115 + 3.173 3.193 0.066
ENSG00000108344 E017 1084.289231 0.0001273449 3.891845e-01 5.332926e-01 17 39995176 39995196 21 + 2.971 2.950 -0.072
ENSG00000108344 E018 1865.979383 0.0009658516 4.641455e-02 1.027831e-01 17 39995197 39995295 99 + 3.172 3.197 0.085
ENSG00000108344 E019 2056.815394 0.0005730679 3.899730e-04 1.735927e-03 17 39995424 39995527 104 + 3.201 3.243 0.139
ENSG00000108344 E020 57.280588 0.0012196915 2.196188e-16 9.062541e-15 17 39995528 39996120 593 + 1.972 1.555 -1.410
ENSG00000108344 E021 2786.364815 0.0016490575 1.878410e-01 3.110113e-01 17 39996183 39996338 156 + 3.352 3.370 0.059
ENSG00000108344 E022 8.279240 0.0047498394 4.558124e-01 5.963062e-01 17 39996701 39996793 93 + 0.968 0.866 -0.385
ENSG00000108344 E023 1784.653495 0.0019847298 5.973006e-01 7.190859e-01 17 39997330 39997380 51 + 3.170 3.173 0.013
ENSG00000108344 E024 2376.239647 0.0011718560 3.893491e-03 1.284521e-02 17 39997504 39997793 290 + 3.263 3.306 0.142
ENSG00000108344 E025 720.854632 0.0007135472 6.297223e-08 6.651742e-07 17 39997794 39997959 166 + 2.698 2.800 0.339