ENSG00000108262

1 Isoform Switch

Summary Plot
Results

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

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isoform_id
gene_id
condition_1
condition_2
gene_name
gene_biotype
iso_biotype
gene_overall_mean
gene_value_1
gene_value_2
gene_stderr_1
gene_stderr_2
gene_log2_fold_change
iso_overall_mean
iso_value_1
iso_value_2
iso_stderr_1
iso_stderr_2
iso_log2_fold_change
IF_overall
IF1
IF2
dIF
isoform_switch_q_value
gene_switch_q_value
PTC
codingPotential
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isoform_id	gene_id	condition_1	condition_2	gene_name	gene_biotype	iso_biotype	gene_overall_mean	gene_value_1	gene_value_2	gene_stderr_1	gene_stderr_2	gene_log2_fold_change	iso_overall_mean	iso_value_1	iso_value_2	iso_stderr_1	iso_stderr_2	iso_log2_fold_change	IF_overall	IF1	IF2	dIF	isoform_switch_q_value	gene_switch_q_value	PTC	codingPotential

ENST00000225394	ENSG00000108262	HEK293_OSMI2_2hA	HEK293_TMG_2hB	GIT1	protein_coding	protein_coding	29.75433	39.99953	21.96691	2.962441	0.2999863	-0.8643549	21.8137854	32.99893260	13.376578	2.11983243	0.5517627	-1.3020692	0.7134083	0.82650000	0.6085333	-0.2179667	2.133795e-09	2.133795e-09	FALSE	TRUE
ENST00000578266	ENSG00000108262	HEK293_OSMI2_2hA	HEK293_TMG_2hB	GIT1	protein_coding	protein_coding	29.75433	39.99953	21.96691	2.962441	0.2999863	-0.8643549	3.2748210	2.82052535	2.563630	0.77633943	0.3864097	-0.1372651	0.1107125	0.06826667	0.1168667	0.0486000	3.121038e-01	2.133795e-09	FALSE	FALSE
ENST00000586574	ENSG00000108262	HEK293_OSMI2_2hA	HEK293_TMG_2hB	GIT1	protein_coding	retained_intron	29.75433	39.99953	21.96691	2.962441	0.2999863	-0.8643549	0.6705303	0.04755674	2.471783	0.04755674	1.2582615	5.4302479	0.0293625	0.00140000	0.1117667	0.1103667	2.628611e-01	2.133795e-09	FALSE	FALSE

Note:
- The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

All exons whithin this gene region are shown and numbering below.

All isoforms whithin this gene region are shown below.

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dispersion
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HEK293_TMG_2hB
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log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
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groupID	featureID	exonBaseMean	dispersion	pvalue	padj	seqnames	start	end	width	strand	HEK293_TMG_2hB	HEK293_OSMI2_2hA	log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB

ENSG00000108262	E001	751.2149456	0.0071951664	5.301856e-11	9.800183e-10	17	29573475	29574171	697	-	2.590	2.890	0.999
ENSG00000108262	E002	386.3950710	0.0007590845	1.146920e-12	2.785291e-11	17	29574172	29574450	279	-	2.384	2.582	0.658
ENSG00000108262	E003	165.5912885	0.0010488865	3.395742e-06	2.511961e-05	17	29574451	29574512	62	-	2.024	2.212	0.629
ENSG00000108262	E004	103.1020688	0.0003377964	1.230048e-03	4.742531e-03	17	29574513	29574524	12	-	1.848	2.000	0.513
ENSG00000108262	E005	506.3584950	0.0002527550	4.799404e-05	2.716236e-04	17	29574525	29574914	390	-	2.578	2.675	0.326
ENSG00000108262	E006	6.3186557	0.0027523239	2.841155e-01	4.243287e-01	17	29574915	29574961	47	-	0.686	0.854	0.673
ENSG00000108262	E007	7.1440611	0.0023888951	6.001322e-01	7.214221e-01	17	29574986	29575078	93	-	0.889	0.841	-0.186
ENSG00000108262	E008	214.0481588	0.0017315287	8.512836e-02	1.676122e-01	17	29575079	29575142	64	-	2.221	2.301	0.266
ENSG00000108262	E009	374.1399286	0.0002563642	7.893914e-02	1.578225e-01	17	29575288	29575470	183	-	2.477	2.536	0.195
ENSG00000108262	E010	10.0434786	0.0254414369	3.526124e-04	1.590584e-03	17	29575471	29575629	159	-	1.264	0.839	-1.558
ENSG00000108262	E011	236.3157231	0.0001702714	5.366157e-01	6.683469e-01	17	29575630	29575703	74	-	2.317	2.322	0.016
ENSG00000108262	E012	119.1520462	0.0002476475	2.163095e-01	3.459678e-01	17	29575812	29575814	3	-	2.043	2.020	-0.078
ENSG00000108262	E013	143.3825789	0.0002353410	6.231538e-01	7.397972e-01	17	29575815	29575829	15	-	2.103	2.108	0.015
ENSG00000108262	E014	196.8126269	0.0002420366	8.874016e-02	1.731955e-01	17	29575830	29575898	69	-	2.263	2.236	-0.089
ENSG00000108262	E015	172.4904110	0.0013500068	5.219448e-01	6.558218e-01	17	29576078	29576131	54	-	2.153	2.197	0.148
ENSG00000108262	E016	1.3619092	0.0098300579	7.437188e-01	8.322926e-01	17	29576132	29576219	88	-	0.293	0.365	0.450
ENSG00000108262	E017	262.6284281	0.0002383512	6.237873e-02	1.306528e-01	17	29576220	29576379	160	-	2.315	2.383	0.227
ENSG00000108262	E018	145.9730367	0.0002235011	1.603794e-01	2.756464e-01	17	29576380	29576450	71	-	2.062	2.129	0.225
ENSG00000108262	E019	2.8388787	0.0062324206	1.684517e-02	4.458945e-02	17	29576451	29576521	71	-	0.765	0.405	-1.648
ENSG00000108262	E020	220.4083807	0.0002388912	6.931465e-02	1.422261e-01	17	29576522	29576674	153	-	2.236	2.307	0.236
ENSG00000108262	E021	126.9105382	0.0035449865	2.146439e-01	3.440241e-01	17	29576863	29576887	25	-	2.075	2.044	-0.104
ENSG00000108262	E022	234.4205703	0.0002164073	2.894765e-05	1.728838e-04	17	29576888	29576996	109	-	2.376	2.292	-0.282
ENSG00000108262	E023	189.3124847	0.0002128026	1.175893e-06	9.623698e-06	17	29577136	29577183	48	-	2.305	2.191	-0.379
ENSG00000108262	E024	213.2895500	0.0002202371	3.000035e-06	2.244570e-05	17	29577184	29577247	64	-	2.349	2.247	-0.339
ENSG00000108262	E025	236.6876686	0.0005779461	2.263351e-05	1.385770e-04	17	29577645	29577742	98	-	2.385	2.294	-0.305
ENSG00000108262	E026	211.2104394	0.0011535171	1.310064e-04	6.632132e-04	17	29578299	29578371	73	-	2.337	2.244	-0.312
ENSG00000108262	E027	165.0652581	0.0031480010	2.084042e-03	7.484371e-03	17	29578731	29578779	49	-	2.237	2.138	-0.332
ENSG00000108262	E028	4.8513041	0.0033512854	8.345362e-01	8.964284e-01	17	29578780	29578961	182	-	0.728	0.714	-0.056
ENSG00000108262	E029	9.5876903	0.0123797711	8.027368e-01	8.743673e-01	17	29578962	29578988	27	-	0.940	0.991	0.190
ENSG00000108262	E030	6.8022385	0.0028626802	4.523985e-02	1.006276e-01	17	29578989	29579330	342	-	1.007	0.782	-0.860
ENSG00000108262	E031	3.4289310	0.0046236313	3.799537e-02	8.734403e-02	17	29581047	29581337	291	-	0.800	0.505	-1.272
ENSG00000108262	E032	157.0301228	0.0017801927	1.407124e-02	3.838657e-02	17	29581338	29581380	43	-	2.194	2.127	-0.222
ENSG00000108262	E033	0.5514428	0.0196430515	3.060923e-01	4.482496e-01	17	29581381	29581479	99	-	0.000	0.220	10.685
ENSG00000108262	E034	207.5302053	0.0009806537	1.514739e-04	7.536580e-04	17	29581742	29581836	95	-	2.330	2.239	-0.303
ENSG00000108262	E035	206.9913548	0.0002384408	1.005195e-05	6.675613e-05	17	29581927	29582064	138	-	2.331	2.233	-0.325
ENSG00000108262	E036	113.4489651	0.0002987625	2.353462e-04	1.114084e-03	17	29582065	29582082	18	-	2.080	1.969	-0.371
ENSG00000108262	E037	154.7990590	0.0002238462	9.109027e-05	4.801820e-04	17	29582083	29582144	62	-	2.207	2.108	-0.332
ENSG00000108262	E038	156.2903309	0.0002371359	3.071208e-04	1.408417e-03	17	29582698	29582759	62	-	2.205	2.115	-0.300
ENSG00000108262	E039	131.5109190	0.0002432764	4.329923e-03	1.406896e-02	17	29582760	29582803	44	-	2.120	2.045	-0.250
ENSG00000108262	E040	0.4375944	0.0257274647	1.502798e-02	4.055045e-02	17	29582804	29582902	99	-	0.389	0.000	-12.629
ENSG00000108262	E041	148.1559664	0.0002379970	2.664163e-02	6.524693e-02	17	29582925	29583037	113	-	2.155	2.105	-0.166
ENSG00000108262	E042	87.7031131	0.0012047602	4.755443e-02	1.048270e-01	17	29583483	29583591	109	-	1.936	1.872	-0.218
ENSG00000108262	E043	38.8497442	0.0105156804	1.203425e-01	2.204683e-01	17	29583592	29583616	25	-	1.608	1.515	-0.319
ENSG00000108262	E044	3.2208457	0.0675749742	5.131522e-01	6.479875e-01	17	29583617	29583872	256	-	0.466	0.615	0.694
ENSG00000108262	E045	27.6500821	0.0193261706	1.809202e-01	3.023721e-01	17	29589327	29589351	25	-	1.469	1.370	-0.342
ENSG00000108262	E046	29.8724897	0.0345152240	1.728318e-05	1.087645e-04	17	29589352	29589648	297	-	1.701	1.267	-1.494
ENSG00000108262	E047	2.5226097	0.0912528943	2.556805e-01	3.925913e-01	17	29593942	29594054	113	-	0.642	0.442	-0.938

Isoforom Switch Analysis

WANG Ziyi

Date: 19 5月 2022

ENSG00000108262

1 Isoform Switch

TableFilter v0.7.3

2 Differential Exon Usage

TableFilter v0.7.3