ENSG00000108239

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000225235 ENSG00000108239 HEK293_OSMI2_2hA HEK293_TMG_2hB TBC1D12 protein_coding protein_coding 2.959966 1.107911 4.842135 0.1232606 0.2110417 2.117815 2.1422800 1.093366 3.2885923 0.1263339 0.1284002 1.579940 0.7884667 0.9859667 0.67993333 -0.30603333 3.318793e-09 3.318793e-09 FALSE TRUE
MSTRG.4403.3 ENSG00000108239 HEK293_OSMI2_2hA HEK293_TMG_2hB TBC1D12 protein_coding   2.959966 1.107911 4.842135 0.1232606 0.2110417 2.117815 0.3067253 0.000000 1.1791478 0.0000000 0.1237831 6.893784 0.0673875 0.0000000 0.24526667 0.24526667 6.322572e-07 3.318793e-09 FALSE TRUE
MSTRG.4403.4 ENSG00000108239 HEK293_OSMI2_2hA HEK293_TMG_2hB TBC1D12 protein_coding   2.959966 1.107911 4.842135 0.1232606 0.2110417 2.117815 0.4450778 0.000000 0.1712667 0.0000000 0.1712667 4.180042 0.1193583 0.0000000 0.03406667 0.03406667 1.000000e+00 3.318793e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000108239 E001 9.0261135 0.0019578434 1.001335e-02 2.879571e-02 10 94402541 94402622 82 + 1.020 0.659 -1.411
ENSG00000108239 E002 11.0585939 0.0015563614 7.352830e-03 2.213455e-02 10 94402623 94402706 84 + 1.101 0.759 -1.291
ENSG00000108239 E003 27.6853553 0.0009025220 5.395333e-05 3.015167e-04 10 94402707 94403410 704 + 1.474 1.129 -1.207
ENSG00000108239 E004 12.4935388 0.0019080040 6.820110e-01 7.855789e-01 10 94403411 94403584 174 + 1.088 1.045 -0.158
ENSG00000108239 E005 14.7124223 0.0012745952 6.673531e-02 1.379677e-01 10 94441896 94442019 124 + 1.189 0.995 -0.702
ENSG00000108239 E006 0.2903454 0.3404996009 1.000000e+00   10 94444471 94444539 69 + 0.132 0.000 -8.369
ENSG00000108239 E007 1.3213160 0.0976766353 8.541874e-02 1.680811e-01 10 94447635 94447670 36 + 0.416 0.000 -10.810
ENSG00000108239 E008 21.4857541 0.0009167089 1.423916e-03 5.386408e-03 10 94474668 94474783 116 + 1.364 1.067 -1.053
ENSG00000108239 E009 21.1271608 0.0064853801 1.591447e-02 4.254196e-02 10 94493365 94493447 83 + 1.347 1.109 -0.841
ENSG00000108239 E010 30.5271599 0.0095508207 6.730967e-02 1.388793e-01 10 94497055 94497172 118 + 1.481 1.316 -0.573
ENSG00000108239 E011 26.9595661 0.0013373653 5.464084e-01 6.766024e-01 10 94500221 94500327 107 + 1.406 1.361 -0.157
ENSG00000108239 E012 23.4833104 0.0022136009 6.636248e-01 7.716256e-01 10 94507267 94507347 81 + 1.326 1.361 0.122
ENSG00000108239 E013 1.8154007 0.0077962914 5.795954e-01 7.044569e-01 10 94508442 94510090 1649 + 0.445 0.340 -0.591
ENSG00000108239 E014 24.2339024 0.0061906731 6.674273e-01 7.746586e-01 10 94510091 94510179 89 + 1.344 1.382 0.132
ENSG00000108239 E015 20.0972072 0.0012507084 4.394421e-01 5.812033e-01 10 94511583 94511654 72 + 1.296 1.230 -0.229
ENSG00000108239 E016 27.7273625 0.0007418237 8.510595e-01 9.076617e-01 10 94521955 94522083 129 + 1.415 1.403 -0.041
ENSG00000108239 E017 23.0382541 0.0008201986 1.430671e-02 3.892640e-02 10 94522344 94522453 110 + 1.378 1.165 -0.745
ENSG00000108239 E018 46.2194190 0.0028302363 5.874759e-01 7.107585e-01 10 94531202 94531460 259 + 1.633 1.603 -0.105
ENSG00000108239 E019 101.0572634 0.0016842073 6.189734e-01 7.364778e-01 10 94533028 94534338 1311 + 1.963 1.944 -0.064
ENSG00000108239 E020 23.1170765 0.0008817175 3.423570e-01 4.863562e-01 10 94534339 94534455 117 + 1.351 1.274 -0.269
ENSG00000108239 E021 106.6296357 0.0004272684 1.333563e-10 2.307354e-09 10 94534456 94535626 1171 + 1.915 2.132 0.727
ENSG00000108239 E022 24.2446231 0.0033844840 3.705399e-17 1.678968e-15 10 94535627 94536332 706 + 1.101 1.714 2.129