ENSG00000108219

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000429989 ENSG00000108219 HEK293_OSMI2_2hA HEK293_TMG_2hB TSPAN14 protein_coding protein_coding 14.18423 17.61877 11.73953 1.6348 0.1372647 -0.5853286 1.3072070 1.036822 1.6435767 0.1550955 0.13190926 0.6595743 0.09592917 0.06043333 0.14023333 0.07980000 0.009495748 0.006524832 FALSE  
ENST00000469149 ENSG00000108219 HEK293_OSMI2_2hA HEK293_TMG_2hB TSPAN14 protein_coding processed_transcript 14.18423 17.61877 11.73953 1.6348 0.1372647 -0.5853286 0.7700451 1.611845 0.4084786 0.1478396 0.09715997 -1.9544100 0.05095833 0.09180000 0.03476667 -0.05703333 0.006524832 0.006524832 FALSE  
MSTRG.4276.4 ENSG00000108219 HEK293_OSMI2_2hA HEK293_TMG_2hB TSPAN14 protein_coding   14.18423 17.61877 11.73953 1.6348 0.1372647 -0.5853286 2.5276968 2.898802 2.1849024 0.2719720 0.29586262 -0.4062681 0.17740417 0.16566667 0.18663333 0.02096667 0.836368852 0.006524832 FALSE  
MSTRG.4276.7 ENSG00000108219 HEK293_OSMI2_2hA HEK293_TMG_2hB TSPAN14 protein_coding   14.18423 17.61877 11.73953 1.6348 0.1372647 -0.5853286 7.8448424 9.053912 6.4995311 1.1430075 0.43234615 -0.4775802 0.55847500 0.51043333 0.55320000 0.04276667 0.706634988 0.006524832 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000108219 E001 0.3729606 0.0295809340 7.001765e-01 7.997006e-01 10 80454166 80454264 99 + 0.151 0.099 -0.701
ENSG00000108219 E002 1.0049449 0.0722561640 1.737618e-01 2.930713e-01 10 80454265 80454268 4 + 0.426 0.180 -1.698
ENSG00000108219 E003 10.8855814 0.0015394945 1.289339e-03 4.940663e-03 10 80454269 80454309 41 + 1.225 0.924 -1.094
ENSG00000108219 E004 14.4932085 0.0012407958 1.025045e-03 4.044818e-03 10 80454310 80454321 12 + 1.321 1.049 -0.966
ENSG00000108219 E005 21.3209927 0.0008785114 6.918617e-04 2.869458e-03 10 80454322 80454328 7 + 1.460 1.226 -0.815
ENSG00000108219 E006 21.5026970 0.0008707885 9.138247e-04 3.662704e-03 10 80454329 80454329 1 + 1.460 1.232 -0.792
ENSG00000108219 E007 41.5909608 0.0005765313 2.019326e-03 7.285518e-03 10 80454330 80454354 25 + 1.692 1.540 -0.516
ENSG00000108219 E008 44.4899268 0.0004882200 7.688707e-03 2.299657e-02 10 80454355 80454371 17 + 1.706 1.583 -0.420
ENSG00000108219 E009 0.0000000       10 80459302 80459507 206 +      
ENSG00000108219 E010 1.6931267 0.0781595506 8.392434e-01 8.995465e-01 10 80463088 80463127 40 + 0.351 0.409 0.327
ENSG00000108219 E011 0.1817044 0.0396843107 7.886703e-01   10 80466441 80466538 98 + 0.000 0.099 9.066
ENSG00000108219 E012 31.7656400 0.0006451889 7.655844e-01 8.482975e-01 10 80468547 80468687 141 + 1.490 1.489 -0.003
ENSG00000108219 E013 0.2214452 0.0383145642 7.880753e-01   10 80489212 80489216 5 + 0.000 0.099 9.081
ENSG00000108219 E014 81.8633079 0.0006106396 2.168826e-02 5.502726e-02 10 80489217 80489314 98 + 1.941 1.867 -0.249
ENSG00000108219 E015 73.2939507 0.0054725936 3.554214e-01 4.997627e-01 10 80504728 80504778 51 + 1.865 1.836 -0.098
ENSG00000108219 E016 1.7984568 0.0081333665 2.470603e-01 3.824756e-01 10 80507199 80507227 29 + 0.263 0.483 1.298
ENSG00000108219 E017 114.4336744 0.0018446342 6.268341e-01 7.427235e-01 10 80507228 80507374 147 + 2.036 2.037 0.003
ENSG00000108219 E018 145.4812412 0.0003374721 2.402045e-01 3.743632e-01 10 80509301 80509471 171 + 2.098 2.153 0.185
ENSG00000108219 E019 18.7347569 0.0010057918 7.156632e-06 4.916425e-05 10 80509472 80509920 449 + 0.928 1.370 1.586
ENSG00000108219 E020 11.5409074 0.0155766974 3.952590e-02 9.015246e-02 10 80510106 80510201 96 + 0.883 1.153 0.991
ENSG00000108219 E021 131.5726945 0.0046608150 7.750303e-01 8.550382e-01 10 80512144 80512269 126 + 2.069 2.104 0.118
ENSG00000108219 E022 2.7645902 0.0058212027 1.152840e-01 2.132729e-01 10 80512719 80512753 35 + 0.351 0.635 1.411
ENSG00000108219 E023 76.4932800 0.0082056923 5.493031e-01 6.790506e-01 10 80514019 80514063 45 + 1.818 1.878 0.202
ENSG00000108219 E024 7.9048579 0.0552248852 8.288500e-01 8.924761e-01 10 80515467 80516203 737 + 0.884 0.932 0.181
ENSG00000108219 E025 125.0455417 0.0048686323 8.606691e-01 9.141331e-01 10 80516204 80516323 120 + 2.054 2.082 0.096
ENSG00000108219 E026 1398.7750215 0.0028646598 1.193218e-01 2.189723e-01 10 80517905 80533124 15220 + 3.093 3.135 0.141