ENSG00000108175

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000334512 ENSG00000108175 HEK293_OSMI2_2hA HEK293_TMG_2hB ZMIZ1 protein_coding protein_coding 8.315518 9.464989 7.649166 1.055781 0.2748806 -0.306937 1.3497511 0.8107911 1.9674161 0.2239814 0.21844960 1.268530 0.1672042 0.08396667 0.2595000 0.1755333 2.312733e-03 2.935311e-05 FALSE TRUE
ENST00000472035 ENSG00000108175 HEK293_OSMI2_2hA HEK293_TMG_2hB ZMIZ1 protein_coding processed_transcript 8.315518 9.464989 7.649166 1.055781 0.2748806 -0.306937 0.5120660 0.2806641 1.1430447 0.1007769 0.15270600 1.988023 0.0619750 0.02833333 0.1484000 0.1200667 2.935311e-05 2.935311e-05 FALSE FALSE
MSTRG.4248.4 ENSG00000108175 HEK293_OSMI2_2hA HEK293_TMG_2hB ZMIZ1 protein_coding   8.315518 9.464989 7.649166 1.055781 0.2748806 -0.306937 0.9275411 1.5296537 0.6413184 0.3645344 0.35071214 -1.241171 0.1131708 0.15690000 0.0850000 -0.0719000 6.372342e-01 2.935311e-05 FALSE TRUE
MSTRG.4248.5 ENSG00000108175 HEK293_OSMI2_2hA HEK293_TMG_2hB ZMIZ1 protein_coding   8.315518 9.464989 7.649166 1.055781 0.2748806 -0.306937 0.2943466 0.0000000 0.4622267 0.0000000 0.46222667 5.561408 0.0343250 0.00000000 0.0577000 0.0577000 8.081260e-01 2.935311e-05 FALSE TRUE
MSTRG.4248.6 ENSG00000108175 HEK293_OSMI2_2hA HEK293_TMG_2hB ZMIZ1 protein_coding   8.315518 9.464989 7.649166 1.055781 0.2748806 -0.306937 4.8296540 6.8341866 3.1367356 0.5070255 0.05095756 -1.121023 0.5696125 0.72983333 0.4115333 -0.3183000 4.402431e-05 2.935311e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000108175 E001 2.0608946 0.1840803567 2.171377e-02 5.508237e-02 10 79068966 79069072 107 + 0.668 0.218 -2.492
ENSG00000108175 E002 2.2187527 0.1325104230 8.346835e-03 2.465861e-02 10 79069073 79069124 52 + 0.699 0.217 -2.630
ENSG00000108175 E003 5.1756365 0.0030886349 1.453381e-04 7.270052e-04 10 79069125 79069233 109 + 0.970 0.549 -1.714
ENSG00000108175 E004 4.0694375 0.0040128425 7.309928e-03 2.202430e-02 10 79069234 79069270 37 + 0.845 0.549 -1.241
ENSG00000108175 E005 11.2663334 0.0147148063 6.087083e-03 1.884034e-02 10 79118915 79119024 110 + 1.177 0.970 -0.750
ENSG00000108175 E006 14.5856809 0.0115771302 2.252774e-03 8.007755e-03 10 79139682 79139777 96 + 1.279 1.075 -0.725
ENSG00000108175 E007 8.0179358 0.0603355427 1.383400e-02 3.784835e-02 10 79162053 79162055 3 + 1.068 0.796 -1.023
ENSG00000108175 E008 13.2150355 0.0013649154 2.255365e-03 8.016061e-03 10 79162056 79162133 78 + 1.231 1.048 -0.655
ENSG00000108175 E009 14.9027895 0.0012214778 1.614495e-02 4.305054e-02 10 79201584 79201692 109 + 1.247 1.137 -0.392
ENSG00000108175 E010 14.8419191 0.0012003367 4.764261e-03 1.527329e-02 10 79208336 79208449 114 + 1.263 1.116 -0.522
ENSG00000108175 E011 16.1943781 0.0012938933 8.947547e-03 2.614824e-02 10 79216169 79216274 106 + 1.287 1.166 -0.424
ENSG00000108175 E012 0.2955422 0.0294864783 8.320873e-01   10 79242821 79242848 28 + 0.125 0.120 -0.073
ENSG00000108175 E013 2.2141822 0.0167867755 2.988817e-01 4.403589e-01 10 79242849 79242969 121 + 0.564 0.463 -0.488
ENSG00000108175 E014 3.4206267 0.0051902638 8.291266e-02 1.641058e-01 10 79243669 79243738 70 + 0.727 0.549 -0.770
ENSG00000108175 E015 0.0000000       10 79277179 79277180 2 +      
ENSG00000108175 E016 32.5679879 0.0059685088 1.414496e-04 7.097843e-04 10 79277181 79277325 145 + 1.606 1.443 -0.558
ENSG00000108175 E017 39.9764131 0.0018300020 2.621602e-05 1.581602e-04 10 79289775 79289889 115 + 1.681 1.544 -0.469
ENSG00000108175 E018 51.4288058 0.0024968630 1.148013e-03 4.464764e-03 10 79290959 79291176 218 + 1.751 1.682 -0.233
ENSG00000108175 E019 35.6983552 0.0012132197 3.886263e-02 8.892871e-02 10 79292158 79292356 199 + 1.564 1.544 -0.068
ENSG00000108175 E020 6.1593314 0.0919597946 1.796877e-01 3.007687e-01 10 79293363 79293380 18 + 0.903 0.776 -0.495
ENSG00000108175 E021 34.9370911 0.0173163584 1.848070e-01 3.072310e-01 10 79293381 79293653 273 + 1.544 1.545 0.003
ENSG00000108175 E022 0.3289534 0.0283940016 8.322000e-01   10 79293654 79296470 2817 + 0.125 0.120 -0.070
ENSG00000108175 E023 30.4413793 0.0097940104 2.184117e-01 3.484974e-01 10 79296471 79296653 183 + 1.478 1.490 0.044
ENSG00000108175 E024 0.4031496 0.0238597131 2.896911e-01 4.304029e-01 10 79296654 79296935 282 + 0.000 0.214 9.623
ENSG00000108175 E025 28.9135666 0.0007534859 1.507075e-03 5.658949e-03 10 79297613 79297690 78 + 1.519 1.417 -0.351
ENSG00000108175 E026 44.0352148 0.0005097430 1.128869e-02 3.184918e-02 10 79298406 79298580 175 + 1.660 1.630 -0.103
ENSG00000108175 E027 47.2418411 0.0058625125 7.861722e-04 3.209731e-03 10 79299050 79299191 142 + 1.733 1.631 -0.346
ENSG00000108175 E028 58.0964413 0.0032642963 2.875282e-06 2.160104e-05 10 79300732 79300942 211 + 1.835 1.695 -0.475
ENSG00000108175 E029 40.8751836 0.0044002472 3.469341e-05 2.030449e-04 10 79302107 79302212 106 + 1.691 1.538 -0.520
ENSG00000108175 E030 53.6283520 0.0060796656 4.089471e-03 1.339288e-02 10 79304015 79304175 161 + 1.761 1.697 -0.218
ENSG00000108175 E031 35.7637360 0.0006306157 5.278072e-03 1.668861e-02 10 79305164 79305231 68 + 1.588 1.528 -0.204
ENSG00000108175 E032 43.5066351 0.0005190484 5.754399e-03 1.796591e-02 10 79305533 79305601 69 + 1.660 1.617 -0.147
ENSG00000108175 E033 67.7218843 0.0004169865 1.548761e-02 4.160107e-02 10 79306100 79306344 245 + 1.826 1.827 0.001
ENSG00000108175 E034 45.7201053 0.0004735141 2.842119e-01 4.244392e-01 10 79307405 79307571 167 + 1.634 1.681 0.162
ENSG00000108175 E035 56.0438056 0.0004825264 2.546141e-01 3.913439e-01 10 79310924 79311184 261 + 1.722 1.772 0.169
ENSG00000108175 E036 1138.9925950 0.0036867483 1.551642e-22 1.314642e-20 10 79312642 79316519 3878 + 2.884 3.151 0.886