ENSG00000108106

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000264552 ENSG00000108106 HEK293_OSMI2_2hA HEK293_TMG_2hB UBE2S protein_coding protein_coding 572.139 1072.033 344.138 72.62266 4.650724 -1.639262 176.53803 370.26727 85.56300 14.045984 2.0232738 -2.113378 0.3075875 0.34686667 0.24853333 -0.09833333 2.888801e-07 2.888801e-07 FALSE  
ENST00000587845 ENSG00000108106 HEK293_OSMI2_2hA HEK293_TMG_2hB UBE2S protein_coding protein_coding 572.139 1072.033 344.138 72.62266 4.650724 -1.639262 28.37148 52.09877 14.42453 6.256662 0.8582479 -1.852002 0.0520500 0.04836667 0.04196667 -0.00640000 6.101075e-01 2.888801e-07 FALSE  
ENST00000589978 ENSG00000108106 HEK293_OSMI2_2hA HEK293_TMG_2hB UBE2S protein_coding protein_coding 572.139 1072.033 344.138 72.62266 4.650724 -1.639262 93.68946 147.91657 67.88760 24.924198 1.8624065 -1.123449 0.1543708 0.13656667 0.19750000 0.06093333 6.136598e-02 2.888801e-07 FALSE  
MSTRG.17715.3 ENSG00000108106 HEK293_OSMI2_2hA HEK293_TMG_2hB UBE2S protein_coding   572.139 1072.033 344.138 72.62266 4.650724 -1.639262 270.84588 498.61274 174.39329 33.803927 4.0915644 -1.515521 0.4789250 0.46520000 0.50663333 0.04143333 4.677841e-02 2.888801e-07 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000108106 E001 5264.01686 0.0001480170 1.372502e-43 5.869446e-41 19 55399745 55401578 1834 - 3.495 3.595 0.331
ENSG00000108106 E002 5888.68355 0.0003002170 5.730780e-23 5.068529e-21 19 55401579 55401713 135 - 3.562 3.641 0.263
ENSG00000108106 E003 5131.87608 0.0004663876 9.885085e-02 1.887250e-01 19 55401714 55401762 49 - 3.568 3.571 0.012
ENSG00000108106 E004 16.11286 0.0348072956 1.787959e-02 4.687890e-02 19 55403908 55404060 153 - 1.362 1.038 -1.148
ENSG00000108106 E005 66.62871 0.0009410781 8.073883e-03 2.396811e-02 19 55404061 55404134 74 - 1.822 1.661 -0.543
ENSG00000108106 E006 41.84832 0.0240800515 3.445699e-01 4.886659e-01 19 55404135 55404147 13 - 1.581 1.476 -0.360
ENSG00000108106 E007 6795.56882 0.0009552830 1.899471e-01 3.136923e-01 19 55404288 55404401 114 - 3.720 3.688 -0.107
ENSG00000108106 E008 5874.27112 0.0006180478 3.524004e-01 4.966621e-01 19 55404402 55404478 77 - 3.651 3.625 -0.086
ENSG00000108106 E009 7233.05472 0.0000601277 1.798699e-20 1.215691e-18 19 55406815 55406962 148 - 3.776 3.706 -0.232
ENSG00000108106 E010 3508.14268 0.0086647520 5.656061e-04 2.404946e-03 19 55407587 55407788 202 - 3.533 3.378 -0.516