ENSG00000108100

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000374706 ENSG00000108100 HEK293_OSMI2_2hA HEK293_TMG_2hB CCNY protein_coding protein_coding 29.49419 34.323 32.3739 2.581198 2.317383 -0.08431906 3.285495 5.105409 2.549739 2.0743765 0.7771622 -0.99885292 0.1108167 0.15826667 0.07593333 -0.082333333 0.6491757063 0.0003051635 FALSE TRUE
ENST00000465416 ENSG00000108100 HEK293_OSMI2_2hA HEK293_TMG_2hB CCNY protein_coding processed_transcript 29.49419 34.323 32.3739 2.581198 2.317383 -0.08431906 7.467024 10.395503 8.277451 2.3426368 1.4986976 -0.32834634 0.2475083 0.29660000 0.25150000 -0.045100000 0.7889423706 0.0003051635 FALSE FALSE
ENST00000492478 ENSG00000108100 HEK293_OSMI2_2hA HEK293_TMG_2hB CCNY protein_coding processed_transcript 29.49419 34.323 32.3739 2.581198 2.317383 -0.08431906 3.206401 2.525036 2.621765 1.2991567 0.7579911 0.05402466 0.1123750 0.06976667 0.07930000 0.009533333 0.8650721421 0.0003051635 FALSE FALSE
MSTRG.3789.13 ENSG00000108100 HEK293_OSMI2_2hA HEK293_TMG_2hB CCNY protein_coding   29.49419 34.323 32.3739 2.581198 2.317383 -0.08431906 5.795886 7.363275 5.948178 0.6537776 0.5351972 -0.30743426 0.1979958 0.21413333 0.18820000 -0.025933333 0.7410163057 0.0003051635 FALSE TRUE
MSTRG.3789.4 ENSG00000108100 HEK293_OSMI2_2hA HEK293_TMG_2hB CCNY protein_coding   29.49419 34.323 32.3739 2.581198 2.317383 -0.08431906 4.198604 2.472195 7.359466 0.6714167 0.3867198 1.56994392 0.1409125 0.07006667 0.23170000 0.161633333 0.0003051635 0.0003051635 TRUE TRUE
MSTRG.3789.6 ENSG00000108100 HEK293_OSMI2_2hA HEK293_TMG_2hB CCNY protein_coding   29.49419 34.323 32.3739 2.581198 2.317383 -0.08431906 4.279784 4.620318 4.003832 1.2645503 0.4101209 -0.20613095 0.1470667 0.13720000 0.12326667 -0.013933333 0.9971658048 0.0003051635 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000108100 E001 0.0000000       10 35247025 35247048 24 +      
ENSG00000108100 E002 0.0000000       10 35247049 35247130 82 +      
ENSG00000108100 E003 0.0000000       10 35248109 35248211 103 +      
ENSG00000108100 E004 0.0000000       10 35250522 35250626 105 +      
ENSG00000108100 E005 0.0000000       10 35289401 35289431 31 +      
ENSG00000108100 E006 0.0000000       10 35327679 35327757 79 +      
ENSG00000108100 E007 0.0000000       10 35332339 35332437 99 +      
ENSG00000108100 E008 24.9234940 0.0130542791 1.581765e-06 1.257652e-05 10 35336509 35336873 365 + 1.602 1.167 -1.512
ENSG00000108100 E009 4.6449220 0.0032936917 4.530267e-08 4.928763e-07 10 35336874 35336926 53 + 1.038 0.209 -4.003
ENSG00000108100 E010 5.3050163 0.0031118116 1.800368e-04 8.781523e-04 10 35336927 35336939 13 + 1.010 0.501 -2.092
ENSG00000108100 E011 6.8195592 0.0057416074 7.416629e-03 2.230180e-02 10 35336940 35336967 28 + 1.038 0.702 -1.300
ENSG00000108100 E012 6.5530600 0.0168794028 5.171716e-02 1.122131e-01 10 35336968 35336969 2 + 0.995 0.729 -1.029
ENSG00000108100 E013 40.7899593 0.0294224404 1.596322e-02 4.264760e-02 10 35336970 35337051 82 + 1.738 1.492 -0.840
ENSG00000108100 E014 134.0831372 0.0073594650 4.266209e-02 9.592667e-02 10 35337052 35337207 156 + 2.186 2.077 -0.363
ENSG00000108100 E015 0.1472490 0.0432119087 4.539623e-01   10 35394816 35394878 63 + 0.128 0.000 -10.539
ENSG00000108100 E016 0.0000000       10 35434111 35434112 2 +      
ENSG00000108100 E017 0.0000000       10 35434113 35434220 108 +      
ENSG00000108100 E018 0.0000000       10 35455357 35455463 107 +      
ENSG00000108100 E019 143.1712058 0.0009905658 1.770213e-02 4.649157e-02 10 35483404 35483478 75 + 2.201 2.121 -0.268
ENSG00000108100 E020 130.2233566 0.0004445076 6.737743e-02 1.389926e-01 10 35501501 35501535 35 + 2.150 2.089 -0.204
ENSG00000108100 E021 0.8126288 0.2884894825 8.822671e-02 1.724186e-01 10 35501536 35501661 126 + 0.000 0.358 10.515
ENSG00000108100 E022 198.1729716 0.0002439084 5.461061e-01 6.763428e-01 10 35516523 35516623 101 + 2.308 2.290 -0.061
ENSG00000108100 E023 0.2955422 0.0287484171 9.455122e-01   10 35525961 35525963 3 + 0.128 0.117 -0.148
ENSG00000108100 E024 135.8372135 0.0007024440 7.006167e-01 8.000442e-01 10 35525964 35525999 36 + 2.142 2.125 -0.055
ENSG00000108100 E025 166.8192047 0.0034770051 6.218640e-01 7.387706e-01 10 35529973 35530030 58 + 2.215 2.226 0.037
ENSG00000108100 E026 0.0000000       10 35530031 35530036 6 +      
ENSG00000108100 E027 199.9524113 0.0008487776 5.909525e-01 7.137721e-01 10 35530124 35530195 72 + 2.294 2.304 0.034
ENSG00000108100 E028 167.4525466 0.0015699495 1.554384e-01 2.689820e-01 10 35530196 35530243 48 + 2.199 2.239 0.136
ENSG00000108100 E029 1.5562728 0.0482379307 1.436171e-01 2.529290e-01 10 35530487 35530510 24 + 0.227 0.500 1.661
ENSG00000108100 E030 335.0532559 0.0016968329 3.345123e-02 7.868097e-02 10 35553019 35553185 167 + 2.494 2.543 0.163
ENSG00000108100 E031 362.0517145 0.0004843292 5.861523e-08 6.224135e-07 10 35566023 35566185 163 + 2.495 2.601 0.355
ENSG00000108100 E032 0.9265960 0.0545152634 8.635951e-02 1.695778e-01 10 35566186 35566285 100 + 0.433 0.117 -2.467
ENSG00000108100 E033 1024.4746347 0.0020571214 2.500628e-01 3.859863e-01 10 35569054 35570659 1606 + 2.998 3.015 0.056
ENSG00000108100 E034 347.5171711 0.0174011711 1.273043e-01 2.303808e-01 10 35570660 35571982 1323 + 2.586 2.500 -0.289
ENSG00000108100 E035 1.2866677 0.0117552389 1.966428e-01 3.220467e-01 10 35571983 35572073 91 + 0.226 0.455 1.437
ENSG00000108100 E036 2.3280440 0.0107403229 2.844028e-01 4.246414e-01 10 35572074 35572669 596 + 0.433 0.611 0.849
ENSG00000108100 E037 0.0000000       10 35583582 35583637 56 +